The objective is to characterize the continued safety of SD-101 cream containing 6% allantoin in the treatment of the skin in patients with Simplex, Recessive Dystrophic, or JEB-nH EB.

Start Date15 Jul 2026

Sponsor / Collaborator

Paradigm Therapeutics, Inc.

NCT07482787

/ Not yet recruitingPhase 3

A Phase 3, Multi-center, Randomized, Double-Blind, Placebo Controlled Study of the Efficacy and Safety of SD-101 Cream in Patients With Epidermolysis Bullosa

The upcoming trial is for EB patients is a topically applied whole-body treatment of patients with either Simplex, RDEB or Junctional (nH) ages 1 month to 12 years old at study entry. There are only 4 site visits by patients with minimal assessments over a 2-month period, and patients completing this study will have the ability to continue receiving SD-101-6.0 at home in an open-label extension study. The drug product and placebo require no special preparation or storage conditions (room temperature).

Start Date15 May 2026

Sponsor / Collaborator

Paradigm Therapeutics, Inc.

CTRI/2023/11/059540

/ RecruitingPhase 4IIT

A Clinical Study to evaluate the 72 hour moisturization potential of Plum Oat & Allantoin All-day Nourishing Cream. - NIL

Start Date15 Nov 2023

Sponsor / Collaborator-

100 Clinical Results associated with Allantoin

100 Translational Medicine associated with Allantoin

100 Patents (Medical) associated with Allantoin

3,287

Literatures (Medical) associated with Allantoin

04 Mar 2026·ANALYTICAL LETTERS

A lab-on-a-tip biosensor for colorimetric detection of uric acid in urine samples using a smartphone

Author: Agustini, Nur Cholifah ; Kuswandi, Bambang ; Hidayat, M. Amrun

A lab-on-a-tip (LOT) has been constructed as a sensing platform for uric acid (UA) in urine.The LOT has been coupled with a smartphone to capture a color change inside the pipet tip wall that has been attached to a paper-based biosensor.Where UA reacted with the uricase to develop the pink color of phenolphthalein as the indicator.Under optimal conditions, the LOT has a linear range from 15 to 90 mg/L toward UA with a detection limit of 8.367 mg/L.The LOT has been applied for UA determination in urine samples with good agreement with spectrophotometry as a reference method.

01 Mar 2026·Current drug discovery technologies

Computational Investigation of Phytochemicals Targeting Isocitrate Lyase to Inhibit Mycobacterium tuberculosis

Article

Author: Kumar, Sanjay ; Sharma, Kuldeep ; Rustagi, Sarvesh ; Mishra, Richa ; Chouhan, Mandeep ; Singh, Deependra Pratap ; Gupta, Saurabh ; Kumar, Mukesh ; Tiwari, Prashant Kumar

Introduction::

The global burden of tuberculosis (TB) remains a major concern for society that is worsening day by day with the emergence of drug-resistant TB as well as risks associated with latent TB. Isocitrate lyase (ICL) has been shown as a potential target that plays a role in the la-tent/dormant stage of M. tuberculosis. Several inhibitors against ICL have been designed and tested, which have various side effects.

Methodology::

This study focuses on the phytochemicals from plant extracts, which have anti-tuber-cular properties. A total of 1413 phytochemicals were virtually screened against ICL to identify the promising therapeutic compounds. The top four lead phytochemicals were selected based on their binding energy and subjected to redocking and intermolecular interaction analysis. These results were further validated through 100 ns MD simulation to check the stability of these complexes. The find-ings of these complexes were compared to the reference compound VGX.

Results::

The top selected compound viz., Allantoin, Gallic acid, Citric acid, and 3,5-Dihydroxyben-zoic acid from virtual screening result displayed better docking score ranging from -8 kcal/mol to -7.2 kcal/mol than the reference compound VGX (-7.5 kcal/mol). Moreover, during the MD simula-tion analysis, gallic acid exhibited greater stability compared to all other compounds, including the reference compound.

Conclusion::

Among selected phytochemicals, gallic acid exhibited highest stability and binding af-finity within the active site of ICL as compared to previously identified compounds, which suggests that it is as potential candidate against ICL. That can be used for further in vitro and in vivo studies to evaluate its effectiveness against TB.

01 Feb 2026·NATURAL PRODUCT RESEARCH

Chemical composition and biological activities of essential oils from Cymbopogon schoenanthus (L.) Spreng.: a Saharan plant from Ghardaïa region (Algeria)

Article

Author: Djemouai, Nadjette ; Baali, Faiza ; Ayari-Guentri, Sofia ; Belaid, Kathia ; BenZetta, Hanane ; Kelai, Elyes ; Saad, Somia

The essential oils (EOs) of Cymbopogon schoenanthus (L.) Spreng. collected from Ghardaïa Province were analyzed for their chemical composition by GC-MS analysis. The results showed fifty-one identified compounds representing 94.34% of the whole EOs, with β-eudesmol (11.35%) and α-elemol (10.84%) as major compounds. The TAC, DPPH, and FRAP antioxidant activities of the EOs were moderate, while an important inhibition of 63.54 ± 2.41% was obtained for the β-carotene bleaching assay. The results of the antibacterial activity show that gentamicin had an inhibition zone of 21.66 ± 0.57 mm while Bacillus cereus was the most sensitive species (inhibition zone of 20.75 ± 0.50 mm). The wound-healing activity results showed contraction percentages on the 20^th day of 99.35 ± 0.12%, which was similar to the positive control 1% allantoin (98.33 ± 0.17%). Our results show that C. schoenanthus is a source of many bioactive compounds with well-known antioxidant, antibacterial and wound-healing properties.

News (Medical) associated with Allantoin

06 May 2025

·www.prnewswire.com

Paradigm Therapeutics, Inc. Announces Investment by Eshelman Ventures, LLC to Support Completion of Development of SD-101 (Zorblisa™), A Topical Therapy for Treatment Across the Entire Skin Surface of All Subtypes of Epidermolysis Bullosa (EB)

First Topical Therapy Developed to Treat the Wounds and Lesions on the Entire Skin Surface Across All EB Subtypes Funding to be Used for Completion of All Activities to Support Planned NDA Submission in the Second Half of 2025, Along with Plans for Commercialization in the U.S. MT PLEASANT, S.C., May 6, 2025 /PRNewswire/ -- Paradigm Therapeutics, Inc., a biopharmaceutical company, announces a $12.5 Million investment by Eshelman Ventures, LLC and appointment of Dr. Eshelman as a strategic advisor for Paradigm. SD-101 (Zorblisa™) is being developed as a topical whole-body treatment for all subtypes of Epidermolysis Bullosa (EB) patients. Funds will be used to complete all activities to support an NDA submission in the later part of 2025. "We are excited about the opportunity to complete the development activities for SD-101 (Zorblisa™) and to move a path forward towards registration of this therapy for patients with all EB subtypes," said Robert Ryan., Ph.D., Chief Executive Officer of Paradigm Therapeutics. "There is a tremendous need for novel whole skin surface treatment options for treating the debilitating skin effects across all patients with Epidermolysis Bullosa. The Paradigm Therapeutics team will be working passionately to provide patients with a new therapeutic alternative in this disease with limited whole-body treatment options. Paradigm's goal is to provide this therapy to patients on a global basis and is working in parallel with potential partners to work towards this goal as quickly as possible." Dr. Ryan added, "Epidermolysis Bullosa is a devastating disease. We believe the clinical data show beneficial effects of the use of SD-101 across the range of EB patients, and strongly support progression towards registration. Results from the completed Phase II and Phase III trials indicate that SD-101 demonstrated a broad benefit with whole body treatment of the lesions and wounds on the entire skin surface in pediatric and adult patients across all EB patients, who have limited whole body treatment alternatives. Results also demonstrated that SD-101 has a favorable safety profile when used long term." "Eshelman Ventures is honored to invest in Paradigm Therapeutics and play a pivotal role in accelerating the development of SD-101 as a transformative treatment for Epidermolysis Bullosa," said Dr. Eshelman, founder of Eshelman Ventures. "As an investor and strategic advisor, I am deeply committed to working closely with this exceptional team as we work tirelessly to bring this innovative therapy to patients in need. The urgency of addressing the challenges faced by EB patients is what drives us; our goal is to provide an improved quality of life in this area of unmet need. Together, we will strive to revolutionize treatment options and make a meaningful impact on the lives of those affected by this debilitating disease." About Epidermolysis Bullosa (EB) Epidermolysis Bullosa is a rare, devastating genetic disorder causing very fragile skin that leads to severe skin blistering and open wounds often beginning at birth. There are no approved therapies that were developed to treat the entire skin surface of patients across all subtypes of EB patients, including wounds and lesional skin, which affects children and adults throughout their lifetimes. EB is a chronic disease, potentially disfiguring, and in some cases fatal. There are many genetic and symptomatic variations of EB, but all forms share the common symptom of fragile skin that blisters and tears, sometimes from the slightest friction or trauma. About SD-101 (Zorblisa™) SD-101 (Zorblisa™) is a topical cream that has demonstrated potential to provide improvement in treating the severe skin disruptions seen in patients across all EB subtypes. Phase II and Phase III studies were conducted in children and adults with either Simplex, Recessive Dystrophic (RDEB), or Junctional EB. A total of 217 EB patients were included in these studies. SD-101 was applied topically over the entire body daily in adults and children as young as 21 days old for a period of three months. The primary outcome measurement was assessment of target wound closure, in addition to secondary measurements including reduction in body surface area (BSA) coverage of blisters and wounds. SD-101 (Zorblisa™) was the first EB treatment to receive the FDA's Breakthrough Therapy designation. SD-101 (Zorblisa™) received Rare Pediatric Disease designation from the U.S. Food and Drug Administration (FDA) covering the broad treatment of EB. In addition to the Rare Pediatric Disease designation, SD-101 was granted Orphan Drug designation from the FDA and the European Commission (EC). Upon approval, Paradigm will be eligible to receive a Priority Review Voucher (PRV). About Paradigm Therapeutics, Inc. Paradigm Therapeutics, Inc. is a privately held, clinical-stage pharmaceutical company focused on developing innovative therapies to address critical medical needs in the treatment of rare diseases. Paradigm's main focus is the treatment of Epidermolysis Bullosa (EB). SD-101 (Zorblisa™), its leading therapy for the treatment of skin effects in patients with Epidermolysis Bullosa, has completed Phase II and Phase III clinical trials. SD-101 (Zorblisa™) is a topical cream that requires no special handling and can be stored at room temperature and has demonstrated potential to provide improvement in treating the severe skin effects seen in patients across all EB subtypes. Forward Looking Statement Except for the historical information contained herein, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties, including: our dependence on third parties for the development, regulatory approval and successful commercialization of our products, the inherent risk of failure in developing product candidates based on new technologies, risks associated with the costs of clinical development efforts, as well as other risks. Actual results may differ materially from those projected. These forward-looking statements represent our judgment as of the date of the release. Paradigm disclaims any intent or obligation to update these forward-looking statements. Company Contact Dr. Robert Ryan Chief Executive Officer [email protected] (919)-274-0703 Logo - WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Phase 3Clinical ResultOrphan DrugBreakthrough TherapyPhase 2

23 Aug 2024

·pharma.economictimes.indiatimes.com

Govt bans 156 medicines including antibiotics, painkillers, multivitamins: Here is the full list

New Delhi: In a significant move aimed at safeguarding public health, the Indian government has banned 156 fixed-dose combination (FDC) drugs, including a variety of antibiotics, painkillers, multivitamins, and medications for treating fever and hypertension. This decision marks the largest crackdown on FDCs since 2016, when 344 such drugs were prohibited. The Union Ministry of Health and Family Welfare issued a gazette notification on Thursday, officially prohibiting the manufacture, sale, and distribution of the banned FDCs. The ban was based on the recommendations of an expert panel that reviewed a total of 324 FDCs. Impact on Pharmaceutical Industry The banned FDCs include popular combinations such as mefenamic acid and paracetamol injections, commonly used for pain relief and fever, and omeprazole magnesium with dicyclomine HCl, used to treat abdominal pain. The ban is expected to impact major pharmaceutical companies, including Sun Pharmaceuticals, Cipla, Dr. Reddy's Laboratories, Torrent Pharmaceuticals, and Alkem Laboratories. Fixed Dose Combinations Drug Banned List Here is a table listing all 156 banned Fixed Dose Combinations (FDCs) SN Fixed Dose Combination (FDC) 1 Amylase + Protease + Glucoamylase + Pectinase + Alpha Galactosidase + Lactase + Beta-Gluconase + Cellulase + Lipase + Bromelain + Xylanase + Hemicellulase + Malt diastase + Invertase + Papain 2 Antimony Potassium Tartrate + Dried Ferrous Sulphate 3 Benfotiamine + Silymarin + L-Ornithine L-aspartate + Sodium Selenite + Folic acid + Pyridoxine hydrochloride 4 Bismuth Ammonium Citrate + Papain 5 Cyproheptadine HCl + Thiamine HCl + Riboflavine + Pyridoxine HCl + Niacinamide 6 Cyproheptadine Hydrochloride + Tricholine Citrate + Thiamine Hydrochloride + Riboflavine + Pyridoxine Hydrochloride 7 Rabeprazole Sodium (As enteric coated tablet) + Clidinium Bromide + Dicyclomine HCl + Chlordiazepoxide 8 Fungal Diastase + Papain + Nux vomica Tincture + Cardamom Tincture + Casein Hydrolysed + Alcohol 9 Mefenamic Acid + Paracetamol Injection 10 Omeprazole Magnesium + Dicyclomine HCl 11 S-adenosyl methionine + Metadoxine + Ursodeoxycholicacid BP + L-Methylfolate Calcium eq. to L- Methylfolate + Choline bitartratee + Silymarin + L-ornithine Laspartate + Inositol + Taurine 12 Silymarin + Thiamine Mononitrate + Riboflavin + Pyridoxine HCl + Niacinamide + Calcium pantothenate + Vitamin B12 13 Silymarin + Pyridoxine HCl + Cyanocobalamin + Niacinamide + Folic Acid 14 Silymarin + Vitamin B6 + Vitamin B12 + Niacinamide + Folic acid + Tricholine Citrate 15 Sodium Citrate + Citric Acid Monohydrate Flavored with Cardamom Oil, Caraway Oil, Cinnamon Oil, Clove Oil, Ginger Oil + Alcohol 16 Sucralfate + Acelofenac 17 Sucralfate + Domperidone + Dimethicone 18 Sucralfate + Domperidone 19 Tincture Ipecacuanha + Tincture Urgenia + Camphorated Opium Tincture + Aromatic Spirit of Ammonia + Chloroform + Alcohol 20 Ursodeoxycholic Acid + Metformin HCl 21 Weak Ginger tincture + Aromatic Spirit of Ammonia + Peppermint Spirit + Chloroform + Sodium Bicarbonate + Compound Cardamom + Alcohol 22 Sucralfate + Pantoprazole Sodium + Zinc Gluconate + Light Magnesium Carbonate 23 Aloe + Vitamin E Soap 24 Povidone Iodine+ Metronidazole + Aloe 25 Azelaic acid + Tea Tree Oil + Salicylic acid + Allantoin + Zinc oxide + Aloe vera + Jojoba oil + Vitamin E + Soap noodles 26 Azithromycin + Adapalene 27 Calamine + Aloes + Allantoin 28 Calamine + Diphenhydramine Hydrochloride + Aloe + Glycerine + Camphor 29 Chlorphenesin + Zinc oxide + Starch 30 Clindamycin Phosphate + Zinc acetate 31 Gamma Benzene Hexachloride + Benzocaine 32 Glucosamine hydrochloride + Diacerein + Menthol + Camphor + Capsaicin 33 Hydroxyquinone 2.0%w/w + Octyl Methoxycinnamate 5.0% w/w + Oxybenzone 30 % w/w 34 Ketoconazole +Zinc Pyrithione +D-Panthenol +Tea Tree Oil +Aloes 35 Ketoconazole +Aloe vera+ Vitamin A Acetate 36 Ketoconazole +Aloes + ZPTO 37 Kojic Acid +Arbutin +Octinoxate +Vitamin E + Mulberry 38 Lornoxicam +capsaicin +menthol+ camphor 39 Lornoxicam + Thiocolchicoside +Oleum Lini +Menthol + Methyl salicylate 40 Menthol + Aloe vera Topical Spray 41 Menthol +Lignocaine HCl +Aloe vera gel +Clotrimazole +Diphenhydramine 42 Miconazole nitrate + Gentamicin + Fluocinolone Acetonide +Zinc Sulphate 43 Miconazole +Tinidazole 44 Minoxidil +Aminexil+ Alcohol 45 Minoxidil +Azelaic acid + saw palmetto 46 Minoxidil +Aminexil 47 Pine Bark extract+ Kojic acid +Sodium Ascorbyl Phosphate 48 Povidone Iodine +Tinidazole +Zinc sulphate 49 Povidone Iodine + Ornidazole + Dexpanthenol 50 Salicyclic acid +Aloe vera+ Allantoin +D-Panthenol 51 Silver sulphadiazine +Chlorhexidine Gluconate solution +Allantoin + Aloe vera gel +Vitamin E acetate 52 Sodium salicylate + Zinc gluconate + Pyridoxine HCl 53 Tetracycline + Colistin Sulphate 54 Clomiphene +Ubidecarenone 55 Combikit of Clomiphene Citrate + Estradiol Valerate 56 Flavoxate HCl +Ofloxacin 57 Clomiphene Citrate +N-Acetylcysteine 58 Primerose Oil +Cod liver oil 59 Sildenafil Citrate +Papaverine +L-Arginine 60 Tranexamic acid +Mefenamic acid + Vitamin K1 61 Divalproex Sodium +Oxcarbazepine 62 Divalproex Sodium + Levetiracitam 63 Ergotamine tartrate +Caffeine + Paracetamol +Prochlorperazine maleate 64 Piracetam + Ginkgo biloba extracts + Vinpocetin 65 Ginkgo biloba + methylcobalamin 66 Ginkgo biloba + methylcobalamin + Alpha lipoic acid +Pyridoxine HCl 67 Ginseng Extract +Dried extract of Ginkgo Biloba 68 Meclizine HCl+ Paracetamol + Caffeine 69 Nicergoline + Vinpocetine 70 Gamma Linolenic Acid + Methylcobalamin 71 Beclomethasone Dipropionate + Neomycin Sulphate + Clotrimazole + Lignocaine HCl 72 Boric acid+ Phenylephrine HCl + Naphazoline Nitrate + Menthol + Camphor 73 Naphazoline HCl + Chlorpheniramine Maleate + Zinc Sulphate + Hydroxy Propyl Methyl Cellulose 74 Chlorpheniramine Maleate + Naphazoline HCl + Zinc Sulphate + Sodium Chloride + Hydroxy Propyl Methyl Cellulose 75 Chlorpheniramine Maleate + Naphazoline HCl + Hydroxy Propyl Methyl Cellulose 76 Chlorpheniramine Maleate + Sodium Chloride + Boric Acid + Tetrahydrozoline HCl 77 Chlorpheniramine Maleate + Phenylephrine HCl + Antipyrine 78 Ketorolac Tromethamine + Chlorpheniramine Maleate + Phenylephrine HCl + Hydroxy Propyl Methyl Cellulose 79 Ketorolac Tromethamine + Flurometholone 80 Naphazoline HCl + Zinc Sulphate + Boric Acid + Sodium Chloride+ Chlorpheniramine Maleate 81 Naphazoline HCl + Hydroxy Propyl Methyl Cellulose + Boric Acid + Borax + Menthol + Camphor 82 Naphazoline HCl + Hydroxy Propyl Methyl Cellulose + Chlorpheniramine Maleate SN Fixed Dose Combination (FDC) 83 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Menthol + Camphor 84 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Sodium Chloride + Hydroxy Propyl Methyl Cellulose 85 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Sodium Chloride + Methylparaben 86 Methenamine + Sodium Benzoate + Benzyl Alcohol 87 Paracetamol + Phenylephrine Hydrochloride + Chlorpheniramine Maleate 88 Paracetamol + Phenylephrine Hydrochloride + Chlorpheniramine Maleate + Caffeine 89 Propoxyphene + Chlorpheniramine Maleate 90 Propoxyphene + Phenylephrine Hydrochloride + Chlorpheniramine Maleate 91 Propoxyphene + Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride 92 Sodium Benzoate + Sodium Citrate + Citric Acid 93 Vitamin A Palmitate + Vitamin C + Vitamin E + Vitamin B6 + Vitamin B12 94 Vitamin A Palmitate + Vitamin C + Vitamin E + Niacinamide 95 Vitamin B6 + Vitamin B12 + Vitamin C 96 Vitamin B6 + Vitamin B12 + Niacinamide 97 Vitamin B12 + Vitamin B6 + Vitamin C + Folic Acid 98 Vitamin B12 + Vitamin B6 + Niacinamide + Folic Acid 99 Vitamin C + Vitamin E + Vitamin A + Niacinamide 100 Vitamin D + Calcium + Magnesium 101 Vitamin D + Calcium + Magnesium + Zinc 102 Calcium + Vitamin D + Vitamin K 103 Calcium + Vitamin D + Magnesium + Zinc 104 Calcium + Vitamin D + Vitamin K + Magnesium 105 Calcium + Vitamin D + Vitamin K + Magnesium + Zinc 106 Vitamin E + Vitamin A + Vitamin C + Niacinamide 107 Vitamin E + Vitamin A + Vitamin C + Folic Acid 108 Vitamin E + Vitamin A + Vitamin C + Biotin 109 Vitamin E + Vitamin A + Vitamin C + Vitamin B12 110 Vitamin E + Vitamin C + Folic Acid 111 Vitamin E + Vitamin C + Biotin 112 Vitamin E + Vitamin C + Vitamin B12 113 Vitamin E + Vitamin C + Zinc 114 Calcium + Vitamin D + Omega-3 Fatty Acids 115 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K 116 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K + Magnesium 117 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K + Zinc 118 Vitamin A + Vitamin C + Vitamin E + Beta-Carotene 119 Vitamin A + Vitamin C + Vitamin E + Beta-Carotene + Zinc 120 Vitamin C + Vitamin E + Beta-Carotene 121 Vitamin C + Vitamin E + Beta-Carotene + Zinc 122 Vitamin C + Vitamin E + Selenium 123 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids 124 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Magnesium 125 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Zinc 126 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Biotin 127 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Selenium 128 Vitamin E + Vitamin A + Vitamin C + Zinc 129 Vitamin E + Vitamin A + Vitamin C + Selenium 130 Vitamin E + Vitamin A + Vitamin C + Biotin 131 Vitamin E + Vitamin A + Vitamin C + Folic Acid + Niacinamide 132 Vitamin E + Vitamin C + Beta-Carotene + Zinc 133 Vitamin C + Vitamin E + Biotin + Folic Acid 134 Vitamin C + Vitamin E + Beta-Carotene + Folic Acid 135 Vitamin C + Vitamin E + Beta-Carotene + Selenium 136 Vitamin E + Vitamin C + Beta-Carotene + Biotin 137 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Biotin 138 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Selenium 139 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Vitamin B12 140 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Vitamin B6 141 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Folate 142 Calcium + Vitamin D + Magnesium + Vitamin K + Omega-3 Fatty Acids 143 Calcium + Vitamin D + Magnesium + Vitamin K + Biotin 144 Calcium + Vitamin D + Magnesium + Vitamin K + Selenium 145 Calcium + Vitamin D + Magnesium + Vitamin K + Vitamin B12 146 Calcium + Vitamin D + Magnesium + Vitamin K + Folate 147 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Vitamin B6 148 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Vitamin B12 149 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Folic Acid 150 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Biotin 151 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Selenium 152 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids 153 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Zinc 154 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Biotin 155 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Selenium 156 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Vitamin B12

Drug Approval

29 Aug 2023

·www.sciencedaily.com

AI-powered triage platform could aid future viral outbreak response

A team of researchers has developed an innovative patient triage platform powered by artificial intelligence (AI) that the researchers say is capable of predicting patient disease severity and length of hospitalization during a viral outbreak. A team of researchers from Yale University and other institutions globally has developed an innovative patient triage platform powered by artificial intelligence (AI) that the researchers say is capable of predicting patient disease severity and length of hospitalization during a viral outbreak. The platform, which leverages machine learning and metabolomics data, is intended to improve patient management and help health care providers allocate resources more efficiently during severe viral outbreaks that can quickly overwhelm local health care systems. Metabolomics is the study of small molecules related to cell metabolism. "Being able to predict which patients can be sent home and those possibly needing intensive care unit admission is critical for health officials seeking to optimize patient health outcomes and use hospital resources most efficiently during an outbreak," said senior author Vasilis Vasiliou, a professor of epidemiology at Yale School of Public Health (YSPH).The researchers developed the platform using COVID-19 as a disease model. The findings were published online in the journal Human Genomics. The platform integrates routine clinical data, patient comorbidity information, and untargeted plasma metabolomics data to drive its predictions. "Our AI-powered patient triage platform is distinct from typical COVID-19 AI prediction models," said Georgia Charkoftaki, a lead author of the study and an associate research scientist in the Department of Environmental Health Sciences at YSPH. "It serves as the cornerstone for a proactive and methodical approach to addressing upcoming viral outbreaks." Using machine learning, the researchers built a model of COVID-19 severity and prediction of hospitalization based on clinical data and metabolic profiles collected from patients hospitalized with the disease. "The model led us to identify a panel of unique clinical and metabolic biomarkers that were highly indicative of disease progression and allows the prediction of patient management needs very soon after hospitalization," the researchers wrote in the study. For the study, the research team collected comprehensive data from 111 COVID-19 patients admitted to Yale New Haven Hospital during a two-month period in 2020 and 342 healthy individuals (health care workers) who served as controls. The patients were categorized into different classes based on their treatment needs, ranging from not requiring external oxygen to requiring positive airway pressure or intubation. The study identified a number of elevated metabolites in plasma that had a distinct correlation with COVID-19 severity. They included allantoin, 5-hydroxy tryptophan, and glucuronic acid. Notably, patients with elevated blood eosinophil levels were found to have a worse disease prognosis, exposing a potential new biomarker for COVID-19 severity. The researchers also noted that patients who required positive airway pressure or intubation exhibited decreased plasma serotonin levels, an unexpected finding that they said warrants further research. The AI-assisted patient triage platform has three essential components: As part of the study, the research team developed user-friendly software -- the COVID Severity by Metabolomic and Clinical Study (CSMC) software -- that integrates machine learning and clinical data to provide pre-hospital patient management and classify patients' conditions when they arrive at the emergency department. "Our model platform provides a personalized approach for managing COVID-19 patients, but it also lays the groundwork for future viral outbreaks," said Vasiliou, chair of the YSPH Department of Environmental Health Sciences and the Susan Dwight Bliss Professor of Epidemiology (Environmental Health Sciences). "As the world continues to grapple with COVID-19 and we remain vigilant against potential future outbreaks, our AI-powered platform represents a promising step towards a more effective and data-driven public health response." Limitations of the study include the fact that all samples were collected between March and May 2020, a time period before the emergence of COVID-19 vaccines and before many treatments for the SARS-CoV-2 virus, such as remdesivir, were available. Such treatments could reduce the changes observed in metabolite biomarkers. Secondly, the population of healthy controls was mainly white, while the COVID-19 patients comprised a higher proportion of Black individuals. As such, the possibility of race /ethnicity being a factor contributing to differences in subjects cannot be excluded. Researchers with the Laboratory of Analytical Chemistry at the National and Kapodistrian University of Athens, Greece; Imperial College of London; and the São Carlos Institute of Chemistry at the University of São Palo, Brazil contributed to the study.

Clinical ResultVaccine

100 Deals associated with Allantoin

External Link

KEGG	Wiki	ATC	Drug Bank
D00121	Allantoin	D02AX	DB11100

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Epidermolysis Bullosa	China	Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd.	01 Jan 1982

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Epidermolysis Bullosa, Junctional, Non-Herlitz Type	Phase 3	United States	Scioderm, Inc.	11 Mar 2015
Epidermolysis Bullosa, Junctional, Non-Herlitz Type	Phase 3	Australia	Scioderm, Inc.	11 Mar 2015
Epidermolysis Bullosa, Junctional, Non-Herlitz Type	Phase 3	Austria	Scioderm, Inc.	11 Mar 2015
Epidermolysis Bullosa, Junctional, Non-Herlitz Type	Phase 3	France	Scioderm, Inc.	11 Mar 2015
Epidermolysis Bullosa, Junctional, Non-Herlitz Type	Phase 3	Germany	Scioderm, Inc.	11 Mar 2015
Epidermolysis Bullosa, Junctional, Non-Herlitz Type	Phase 3	Israel	Scioderm, Inc.	11 Mar 2015
Epidermolysis Bullosa, Junctional, Non-Herlitz Type	Phase 3	Italy	Scioderm, Inc.	11 Mar 2015
Epidermolysis Bullosa, Junctional, Non-Herlitz Type	Phase 3	Lithuania	Scioderm, Inc.	11 Mar 2015
Epidermolysis Bullosa, Junctional, Non-Herlitz Type	Phase 3	Netherlands	Scioderm, Inc.	11 Mar 2015
Epidermolysis Bullosa, Junctional, Non-Herlitz Type	Phase 3	Poland	Scioderm, Inc.	11 Mar 2015

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02014376 (CTgov)	Phase 2	Epidermolysis Bullosa \| Epidermolysis Bullosa, Junctional, Non-Herlitz Type	48	SD-101 (SD-101 Dermal Cream (6%))	kpexyejevr = nonnsrqbtc repvtwpcdw (tezpdtncrn, cqjehsthwh - goecbadyfl) View more	-	13 Jan 2020
				SD-101 (SD-101 Dermal Cream (3%))	kpexyejevr = jyhowsatuw repvtwpcdw (tezpdtncrn, xfhckdbqdc - kreoztredo) View more
NCT02670330 (CTgov)	Phase 3	Epidermolysis Bullosa	152	SD-101 (SD-101-6.0 to SD-101-6.0)	ywafhkenma = rmysgiucrb rbgvmvfxov (szvlkosekd, depsnfdmrn - looqsutkif) View more	-	02 Aug 2019
				Placebo (Placebo to SD-101-6.0)	ywafhkenma = pxdxafuffz rbgvmvfxov (szvlkosekd, apukrtoggr - zihaxmcwls) View more
NCT02384460 (ESSENCE, CTgov)	Phase 3	Epidermolysis Bullosa \| Epidermolysis Bullosa, Junctional, Non-Herlitz Type	169	SD-101-6.0 cream (SD-101-6.0 Cream)	uxbytaxcbl(qmbmsninnc) = voyxvymzah dleajivwxs (bchxrnplan, 25.50) View more	-	16 Oct 2018
				Placebo (SD-101-0.0) cream (Placebo (SD-101-0.0) Cream)	uxbytaxcbl(qmbmsninnc) = prmjazmgia dleajivwxs (bchxrnplan, 28.59) View more

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Hiro LS Researcher

The AI Search Engine Built to Accelerate Biopharma Decisions

Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.

Ask any biopharma research question→

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Discover Synapse Data Servers

Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis