To the Editor,Latrodectus geometricus, commonly known as the brown widow, is an invasive species of widow spider to the United States that is becoming increasingly prevalent, particularly in urban ...

01 Jan 2012·Clinical ToxicologyQ3 · MEDICINE

Examination of adverse events following black widow antivenom use in california

Q3 · MEDICINE

Article

Author: Kacie Berk ; F. Lee Cantrell ; Richard F. Clark ; Sean Patrick Nordt ; Angie Lee

OBJECTIVESFollowing widow spider (Latrodectus sp.) envenomation, local pain, erythema, abdominal pain, rigidity, hypertension, and diaphoresis can be seen. While an effective specific antivenom (AV) is available, its use is limited due to concern of possible severe allergic reaction. We performed the current study to determine rate of adverse effects and the efficacy of AV in patients treated for widow spider envenomation.METHODSObservational case series of the California Poison Control System electronic database from January 1999 to December 2009. All cases of widow spider envenomation treated with AV were included. Age, gender, signs, and symptoms, adjunctive therapy, number of vials of AV given, and adverse reaction to AV were recorded. Descriptive statistical methods were used.RESULTSNinety-six patients received AV, mean age 26 years (0.12-74 years), 76% male. Following widow spider envenomation generalized pain was reported in 91%, erythema at site in 57%, hypertension (≥ 140/90 mmHg) in 43%, muscle rigidity/cramping in 43%, abdominal pain in 41%, tachycardia (≥ 100 bpm) in 23% and diaphoresis in 21%. No patient required more than one vial of AV. One patient developed urticaria to AV halfway through infusion which was immediately discontinued. Another patient developed generalized flushing following completion of infusion but had no other effects. Two other patients reported myalgia and paresthesia. There were no deaths in any patients receiving AV. There was no shortness of breath or respiratory distress, no hypotension or chest pain following AV administration. All patients reported pain relief with AV and did not require additional AV doses.CONCLUSIONSOur results suggest that Black Widow Spider Antivenin® (Merck) administration is relatively safe with mild to moderate adverse effects seen in only a small percentage of patients. There were no deaths, or severe allergic reactions identified. The retrospective use of poison control system data is a limitation of our study. Further prospective studies are needed to validate our findings and elucidate the full safety profile on this antivenom.

01 Dec 2011·Journal of Medical ToxicologyQ4 · MEDICINE

Anaphylaxis with Latrodectus Antivenin Resulting in Cardiac Arrest

Q4 · MEDICINE

Article

Author: Jeannie J. Hong ; Christine M. Murphy ; Michael C. Beuhler

Latrodectus mactans antivenin is a safe and effective therapy for severe black widow spider envenomations when given to most patients. We report a case of a 37-year-old male with a history of asthma that was given L. mactans antivenin for symptoms related to a black widow envenomation and developed a severe anaphylactic reaction resulting in cardiac arrest. When traditional therapies failed, the patient was given methylene blue for anaphylactic shock resulting in a 30-h period of hemodynamic stability. Despite initial resuscitation, the patient ultimately died 40 h after presentation. Under the right circumstances, L. mactans antivenin remains a safe and effective therapy for severe black widow envenomations. However, anaphylaxis is a risk for those receiving this therapy, even when the antivenin is diluted and given as an infusion. We report the first death related to diluted L. mactans antivenin given as an infusion.

100 Deals associated with Antivenin (Latrodectus mactans)(Merck Sharp & Dohme)

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KEGG	Wiki	ATC	Drug Bank
-	-	L01XC	DB14113

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Indication	Country/Location	Organization	Date
Spider venom poisoning	US	Merck Sharp & Dohme LLC	13 Feb 1936

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