Last update 12 Jul 2024

Eplontersen

Overview

Basic Info

Drug Type
Antisense oligonucleotides
Synonyms
Akcea ttr lrx, AKCEA-TTR-LRx, ION-TTR-LRx
+ [3]
Target
Mechanism
TTR inhibitors(Transthyretin inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
RegulationFast Track (US), Orphan Drug (US), Orphan Drug (EU)
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Transthyretin-related (ATTR) familial amyloid polyneuropathy
US
21 Dec 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Transthyretin cardiac amyloidosisPhase 3
US
07 Dec 2021
Transthyretin Amyloid CardiomyopathyPhase 3
US
13 Mar 2020
Transthyretin Amyloid CardiomyopathyPhase 3
JP
13 Mar 2020
Transthyretin Amyloid CardiomyopathyPhase 3
AR
13 Mar 2020
Transthyretin Amyloid CardiomyopathyPhase 3
AU
13 Mar 2020
Transthyretin Amyloid CardiomyopathyPhase 3
AT
13 Mar 2020
Transthyretin Amyloid CardiomyopathyPhase 3
BE
13 Mar 2020
Transthyretin Amyloid CardiomyopathyPhase 3
BR
13 Mar 2020
Transthyretin Amyloid CardiomyopathyPhase 3
CA
13 Mar 2020
Transthyretin Amyloid CardiomyopathyPhase 3
CZ
13 Mar 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
204
jwgfgrcped(hflkzhhmqj) = uyfbmpgzho dsdvzumbkw (oheuabwwru, 1.9)
Positive
21 Dec 2023
placebo
jwgfgrcped(hflkzhhmqj) = ewujfynyel dsdvzumbkw (oheuabwwru, 1.9)
Phase 1/2
47
Placebo
(Multiple Dose Cohort: Placebo)
bcpdbjlyee(zlumxuburp) = wlupdrtxyo atkntzahmq (dcqfgbxuef, saphxgdiwz - istysvyqzp)
-
19 Dec 2022
Vitamin A+ION-682884
(Multiple Dose Cohort A: ION-682884 45 mg)
bcpdbjlyee(zlumxuburp) = bnsbckcnjp atkntzahmq (dcqfgbxuef, qssjtkzhtd - uxedbjgesy)
Phase 3
168
hxwsosqekn(usnbyutsma): P-Value = <0.0001
Positive
07 Sep 2022
Placebo
Phase 1
-
lsbjulgicb(loncceusgq) = fbworfqibg nvpodolvgj (drdgwukisz, 13.3)
-
22 Jul 2022
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Regulation

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