Last update 29 Mar 2025

Firazorexton

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
TAK 994, TAK994
Target
Action
agonists
Mechanism
OX2R agonists(Orexin receptor type 2 agonists)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationBreakthrough Therapy (China), PRIME (European Union), Breakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC22H25F3N2O4S
InChIKeyVOSAWOSMGPKQEQ-OALUTQOASA-N
CAS Registry2274802-95-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CataplexyPhase 2
United States
28 Feb 2020
CataplexyPhase 2
Canada
28 Feb 2020
CataplexyPhase 2
Czechia
28 Feb 2020
CataplexyPhase 2
Finland
28 Feb 2020
CataplexyPhase 2
France
28 Feb 2020
CataplexyPhase 2
Hungary
28 Feb 2020
CataplexyPhase 2
Italy
28 Feb 2020
CataplexyPhase 2
Netherlands
28 Feb 2020
CataplexyPhase 2
Spain
28 Feb 2020
NarcolepsyPhase 2
Netherlands
28 Feb 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
97
Placebo
(Part A: Placebo)
bymlmlmbsj = ojmkqxvkeu jeriknggkm (hcsivxxwir, rvahwtzpnk - kpvfkehlry)
-
29 Oct 2024
(Part A: TAK-994 120 mg)
bymlmlmbsj = tlikikqycj jeriknggkm (hcsivxxwir, vorxqnvgih - nqkqvosarx)
Not Applicable
-
TAK-994 high-dose (HD)
gaiwoaizrw(irmtugezjg) = Urinary-related events were the most frequently reported TEAEs with TAK-994 imeiojrian (jzjuvtlfbw )
-
23 Oct 2023
TAK-994 low-dose (LD)
Phase 2
73
nzofoddulf(xauovkwvkr) = yphnikuavt ejkmobmljt (flhjxxgtvs )
Negative
27 Jul 2023
nzofoddulf(xauovkwvkr) = zryuagnwul ejkmobmljt (flhjxxgtvs )
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Approval

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Regulation

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