A Clinical study to evaluate the Safety and efficacy of hyaluronic acid injection containing stromal vascular fraction extracted from adipose tissue of patients with enophthalmos

Start Date31 Jan 2025

Sponsor / Collaborator

Bundang CHA Hospital

CTRI/2024/11/077456

/ Not yet recruitingNot ApplicableIIT

Effectiveness of 0.1 percent Hyaluronic Acid with 0.2 percent Chlorhexidine Mouthrinse or 0.2 percent Chlorhexidine Mouthrinse alone as adjunct to scaling and root planing on clinical parameters and salivary aspartate aminotransferase marker in Periodontitis : A Prospective randomized observer blinded study - NIL

Start Date10 Dec 2024

Sponsor / Collaborator

Dr. Reddy's Laboratories Ltd.

NCT06310941

/ Not yet recruitingNot ApplicableIIT

Aspiration of Bronchial Secretions With Mechanical Insufflation-Exsufflation and Hypertonic Saline in Bacterial Nosocomial Tracheobronchitis and Pneumonia in Intubated Patients.

Multicenter, randomized open label clinical trial to evaluate IEM and HS as concomitant therapy for respiratory tract infection in patients under artificial ventilation in the ICU.
Lung infection is a serious complication that may occur during hospital stay and may need artificial respiration or even develop during artificial ventilation for other causes.
Current specific treatment consists of intravenous antibiotics. The current study evaluated whether aspiration and drainage of infected sputum helps curing this severe complication and whether nebulized HS has additional benefits, like eradicating bacteria or reducing inflammation.

Start Date01 Dec 2024

Sponsor / Collaborator

Hospital San Carlos, Madrid

100 Clinical Results associated with Hyaluronic acid

100 Translational Medicine associated with Hyaluronic acid

100 Patents (Medical) associated with Hyaluronic acid

520

Literatures (Medical) associated with Hyaluronic acid

01 Apr 2025·INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Hyaluronic acid-mediated targeted nano-modulators for activation of pyroptosis for cancer therapy through multichannel regulation of Ca2+ overload

Article

Author: Xu, Ziqiang ; Kuang, Ying ; Liao, Tao ; Wang, Jinyu ; Ma, Yiming ; Xing, Zihan ; Wu, Xiaomei ; Li, Cao ; Guo, Yuhao ; Li, Linwei

Calcium-based nanomaterials-mediated Ca²⁺ overload-induced pyroptosis and its application in tumor therapy have received considerable attention. However, the calcium buffering capacity of tumor cells can maintain mitochondrial calcium homeostasis, so it is important to effectively disrupt this homeostasis to activate pyroptosis. Here, a nano-modulator CUR@CaCO₃-PArg@HA (CCAH) was developed to regulate calcium overload in multiple channels and activate pyroptosis. Hyaluronic acid (HA)-coated nano-modulators achieve tumor targeting, and under the weakly acidic conditions of the tumor microenvironment (TME), CaCO₃ nanoparticles rapidly release curcumin (CUR), inhibit the outflow of intracellular Ca²⁺, and release exogenous Ca²⁺. Meanwhile, poly-L-arginine (PArg) reacts with reactive oxygen species (ROS) generated by mitochondrial imbalance, releasing nitric oxide (NO) and stimulating the endoplasmic reticulum to release endogenous Ca²⁺. The combined action of endogenous and exogenous Ca²⁺ effectively activates caspase-1, which cleaves gasdermin-D (GSDMD) to produce the active N-terminus (GSDMD-N), effectively activating pyroptosis. Notably, the generated ROS and NO can also generate more oxidizing ONOO^-, further exacerbating the imbalance in mitochondrial homeostasis. This work demonstrates that simultaneous modulation of exogenous and endogenous Ca²⁺ can disrupt mitochondrial Ca²⁺ homeostasis and effectively activate pyroptosis to treat tumors, which is expected to promote the progression of cancer treatment in the future.

01 Feb 2025·CARBOHYDRATE POLYMERS

Polysaccharide-based hydrogels for atopic dermatitis management: A review

Review

Author: Tan, Joash Ban Lee ; Rao, Harinash

Atopic dermatitis (AD) is the most common form of eczema and the most burdensome skin disease globally, affecting nearly 223 million. A major AD predisposition is genetic susceptibility, affecting skin barrier integrity and cell-mediated immunity. Manifesting as red, dry, and itchy skin, basic treatment involves skin hydration with emollients. Despite their effectiveness, poor patient compliance remains a major drawback. In severe cases, medicated emollients are used, but carry risks, including skin thinning, and immunosuppression. Hence, hydrogels have emerged as a promising alternative for AD management based on their ability to improve skin hydration, attributed to their hydrophilicity and high water retention capacity. Moreover, researchers have loaded hydrogels with various compounds for AD management; they also hold the potential to reduce systemic side effects of commercial drugs by enhancing dermal retention. Hydrogels address the challenges of patient compliance based on their non-greasy texture and reduced application frequency. Their appeal also stems from their versatility, as they can be fabricated from varying polymers. Due to their abundance, this review focuses on polysaccharides including alginate, cellulose, chitosan, and hyaluronic acid, which are preferred for fabricating natural and modified natural hydrogels for AD. It also briefly explores hydrogel application methods and key AD models.

01 Feb 2025·CLINICAL RHEUMATOLOGY

A critical overview of systematic reviews and meta-analyses of intra-articular injection of platelet rich plasma versus hyaluronic acid for knee osteoarthritis

Review

Author: Yu, Weijie ; Ye, Yuntian ; Shen, Jianzeng ; Zhou, Qinxin ; Cao, Dongdong ; Chen, Jixin

This study is to summarize and evaluate the available evidence for the efficacy of platelet-rich plasma (PRP) and hyaluronic acid (HA) for knee osteoarthritis (KOA). Eight databases were searched from inception to September 15, 2024. All systematic reviews (SRs)/meta-analyses (MAs) treated with PRP versus HA for KOA were collected. Literature screening and data extraction were independently performed by two reviewers. The methodological quality, reporting quality, risk of bias, evidence quality, and evidence overlap rate of the included studies were evaluated by using AMSTAR 2, PRISMA 2020, ROBIS, GRADE, and GROOVE systems. Seventeen SRs were included. The results showed that the effectiveness and safety of PRP in the treatment of KOA may be superior to HA. The methodological quality of all 17 documents was extremely low quality. Sixteen of them had poor reporting quality, and there were relatively serious information deficiencies. All SRs were determined to be at high risk. Among the 221 outcome indicators, there were two medium-quality evidences, 30 low-quality evidences, and 189 extremely low-quality evidences. It was found that there was a very high overlap among the included articles. Currently, the quality of SRs on the treatment of KOA with PRP versus HA is relatively low. Future authors of SRs should adhere to quality assessment tool criteria, expand sample sizes to reduce overlap, and evaluate the quality of evidence for merged study results, in order to provide more reliable and rigorous evidence-based support for clinical practice.

News (Medical) associated with Hyaluronic acid

01 Aug 2024

·www.prnewswire.com

Sirnaomics Announces a Partnership with Gore Range Capital for Establishment of a JV, Sagesse Bio, to Advance Its RNAi Therapeutics into Aesthetic Medicine

HONG KONG, GERMANTOWN, Md. and SUZHOU, China, July 31, 2024 /PRNewswire/ -- Sirnaomics Ltd. (the " Company", Stock Code: 2257.HK, together with its subsidiaries, the " Group" or " Sirnaomics"), a leading biopharmaceutical company engaging in discovery and development of advanced RNAi therapeutics, today announced a partnership with Gore Range Capital LLC (" Gore Range Capital") (Dallas, TX, USA) for establishment of a joint venture, Sagesse Bio, Inc., to advance its novel RNAi therapeutic products into aesthetic medicine. Sagesse Bio, Inc., a Delaware corporation (" Sagesse Bio"), combines the strength of Sirnaomics' leadership in RNAi-based technology and product development for focal fat reduction and Gore Range Capital's world leading expertise in skin health industry and financial resources, to accelerate clinical development of the company's innovative products for addressing a fast-growing aesthetic medicine market. Sagesse Bio will rapidly advance Sirnaomics lead compound that is IND-enabled and currently in Phase II clinical trials for other indications. Initial indications of interest include body contouring and fat reduction. The founders, board of directors, and newly established executive management team of Sagesse Bio are comprised of a group of well-accomplished senior executives from skin health industry, world-renowned clinicians in dermatology and aesthetic medicine, and leading experts in RNAi medicine. The strategic goal of Sagesse Bio is to become a world-leading aesthetic medicine company with innovative technologies and aesthetic products. Frederick Beddingfield, MD, PhD, serving as Chairperson of the board of directors of Sagesse Bio, is an internationally renowned dermatologist and expert in biopharma and the aesthetics industry, who has led the development of global leading brands such as BOTOX®, JUVEDERM®, LATISSE® and KYBELLA®. He served as Chief Medical Officer of Allergan Medical and Kythera, and as CEO of Sienna Bio and Kira Pharmaceuticals, and currently serves on the board of directors of Cytrellis Biosystems. Dr. Beddingfield stated: "I could not be more excited to help lead and build Sagesse Bio. We have an amazing team with the right experience and a unique opportunity based on the finding of adipocytolysis with good tolerability in human clinical studies, to rapidly advance our IND-approved lead product." Mr. Humberto Antunes, co-founder of Sagesse Bio, partner of Gore Range Capital, former Chairman and CEO of Galderma/Nestlé Skin Health, an internationally renowned executive in skin health industry, comments: "The strategic goal of Sagesse Bio is to deliver innovative and life changing therapies to patients with an initial emphasis on focal fat destruction." "We are thrilled to build this historic partnership: RNAi therapeutic candidate is moving into medical aesthetic product development for body contouring," commented Dr. Patrick Lu, founder, Chairman of the board, executive director, President and CEO of Sirnaomics. "The joint expertise and resources from both Sirnaomics and Gore Range Capital are setting up a strong foundation for a tremendous growth potential of Sagesse Bio with its accelerated product development speed." The board of directors of the Company has approved, and the board of directors and the stockholders of Sagesse Bio have approved, a series of agreements in relation to the partnership (the "Agreements"). The Company and Sagesse Bio have signed the Agreements, which shall become effective only upon being approved by the shareholders of the Company at an upcoming general meeting. Under the partnership arrangement, Sagesse Bio will initiate a clinical evaluation immediately for its leading product candidate, SGY-101, with scientific and technical support from Sirnaomics, receiving assignment and licensing of certain relevant intellectual property rights for the licensed product. In return, Sirnaomics will receive milestone payments of up to US$33 million and a majority equity position of Sagesse Bio with value of approximately US$36 million upon successful equity or debt financing in the future at a minimum pre-financing valuation of Sagesse Bio at US$60 million. Gore Range Capital is responsible for initial funding and building the executive management team and advisory board. In addition, with its well-built domain expertise and extensive networks in the skin health industry, Gore Range Capital is able to provide a hands-on approach for Sagesse Bio's fundraising and business development challenges. About Gore Range Capital Gore Range Capital is focused on investments in the skin health businesses. Gore Range's approach is simple: "We invest in what we know." Over the course of their respective careers the Gore Range team has built domain expertise and extensive networks across multiple areas of healthcare. Through Gore Range Capital, capabilities are channeled to focus on the largest organ and the most visible manifestation of personal identity: the skin. At Gore Range, the hands-on approach of operationally focused private equity is blended with the early-stage guidance needed in venture capital. Formed in 2015, Gore Range works closely with portfolio companies and industry leaders to bring skin health innovations to market. To accomplish this mission, Gore Range leverages its team of experienced healthcare investors, leaders, and practitioners to bring strategic, financial and scientific expertise to its investments. Learn more at: . About Sirnaomics Sirnaomics is an RNA therapeutics biopharmaceutical company that focuses on the discovery and development of innovative drugs for indications with unmet medical needs and large market opportunities. Sirnaomics is the first clinical-stage RNA therapeutics company to have a strong presence in both Asia and the United States. Based on its proprietary delivery technologies, a polypeptide nanoparticle RNAi platform and GalNAc RNAi platform, GalAhead™, Sirnaomics has established an enriched drug candidate pipeline. STP122G, which represents the first drug candidate utilizing the Company's GalAhead™ mxRNA technology, is currently in Phase I development. STP237G is the first dual-targeted drug based on a GalAhead™ muRNA technology and is in the late stage of preclinical development. The Company has also had multiple successes with oncology applications through its clinical programs for STP705 and STP707. With the establishment of the it manufacturing facility in China, Sirnaomics is undergoing a transition from a biotech company to a biopharma corporation. Learn more at: . CONTACT: USA Media Contact: George Ji, MBA Head of Finance and Administration Email: [email protected] Asia Media Contact: Johnson Shen, M.A. Senior Business Manager for Investor Relations Email: [email protected] SOURCE Sirnaomics

Phase 1Phase 2

02 Apr 2024

·www.biospace.com

Nordic Group B.V. Through Its Subsidiary Nordic Pharma, Inc. (U.S.), to Present Data on LACRIFILL® Canalicular Gel, a Novel Therapy for Dry Eye, at the American Society of Cataract and Refractive Surgery Annual Meeting

BERWYN, Pa.--(BUSINESS WIRE)-- Nordic Pharma, Inc., a subsidiary of Nordic Group B.V., will be presenting data on LACRIFILL® Canalicular Gel, a novel therapy for dry eye symptoms, during the American Society of Cataract and Refractive Surgery (ASCRS) Annual Meeting in Boston, MA on April 5-8, 2024. LACRIFILL Canalicular Gel is a cross-linked hyaluronic acid derivative and is FDA-cleared to temporarily block tear drainage by the occlusion of the canalicular system. “These are truly exciting times for Nordic Pharma as we near the U.S. launch of LACRIFILL Canalicular Gel, a key milestone in our global expansion strategy,” said Charlotte Phelps, CEO of Nordic Pharma. “The recent acquisition of Visant Medical along with Amring Pharmaceuticals becoming Nordic Pharma, Inc., has increased our internal know-how and assets. And with our strong U.S. leadership team and the invaluable support of our Medical Advisory Board, I firmly believe that Nordic Pharma is well-positioned to thrive as a new specialty ophthalmic player and enhance patient care by introducing this novel therapy for dry eye.” “As chairperson of the LACRIFILL U.S. Medical Advisory Board, I am excited about the potential of employing a cross-linked hyaluronic lacrimal filler to optimally occlude the canalicular system to maximize tear film preservation in patients with dry eye symptoms,” said Eric D. Donnenfeld, MD. ASCRS attendees are invited to stop by booth #1245 to learn how LACRIFILL Canalicular Gel is changing practice and changing lives. Attendees will also have the opportunity to be among the first Eye Care Professionals to place orders. LACRIFILL Canalicular Gel will be featured at various Refractive and Cornea Day sessions throughout the meeting, including the “LACRIFILL: A Paradigm Shift in Dry Eye Intervention” panel, which will be held on Saturday, April 6th, 2024 and will include the distinguished faculty of Eric Donnenfeld; MD, Preeya Gupta, MD; Darrell White, MD; and Kevin J. Corcoran, COE, CPC, CPMA, FNAO and the Principal of Corcoran & Corcoran. Mark Packer, MD, FACS, CPI, who will be moderating the panel said, “As a lacrimal filler, cross-linked hyaluronic acid provides a new approach to preservation of the tear film, protecting and conforming to delicate tissues while blocking outflow. LACRIFILL Canalicular Gel transforms treatment of the ocular surface, with demonstrated safety and effectiveness for both signs and symptoms of dry eye.” Chief Commercial Officer of Eye Care U.S., Jai Parekh, MD, MBA said, “I am thrilled for Nordic Pharma to be presenting data on LACRIFILL Canalicular Gel at a meeting as important as ASCRS. This is where science and innovation come together, making it the perfect environment to highlight this novel therapy for dry eye.” For more information and ordering details for LACRIFILL Canalicular Gel visit lacrifill.com. About Nordic Group B.V. Nordic Group B.V. is a privately owned, medium-size international pharmaceutical company which focuses on the development and commercialization of specialty products. Portfolio enhancement has been accomplished through targeted developments and focused acquisitions to build a foundation in Eye Care, Rheumatology and Women’s Health. Nordic Pharma has established deep roots throughout Europe, and more recently, expanded outside of Europe with increased acquisitions worldwide. Nordic Pharma is a part of SEVER Life Sciences, a holding company created in 2019 that brings together three diverse but complementary companies that offer a wide range of products, pharmaceutical development services and delivery technologies. About Nordic Pharma, Inc. Nordic Pharma, Inc., subsidiary of Nordic Group B.V., is partnered with well-established global biopharmaceutical companies and is uniquely positioned to leverage its expertise in bringing biotechnology derived medicines, sterile manufacturing and other state-of-the-art technologies to the marketplace. Safe Harbor This press release contains forward-looking statements, including, without limitation, statements related to Nordic Group /Nordic Pharma’s business developments and the implementation of Nordic Group /Nordic Pharma’s strategic initiatives. Because these statements reflect Nordic Group /Nordic Pharma’s current views, expectations and beliefs concerning future events, these forward-looking statements involve risks and uncertainties that could cause actual developments and results to differ materially from Nordic Group /Nordic Pharma’s expectations. These factors include, but are not limited to, general market conditions, regulatory trends, changes in the financial conditions of third parties dealing with Nordic Group /Nordic Pharma, and other factors that could affect Nordic Group /Nordic Pharma’s business and financial performance. Nordic Group /Nordic Pharma does not assume any obligation to publicly update any forward-looking statements, whether as a result of new information, future developments or otherwise. Disclaimer All educational content of the ASCRS Annual Meeting is planned by its program committee, and ASCRS does not endorse, promote, approve, or recommend the use of any products, devices, or services. View source version on businesswire.com: Contacts Nordic Pharma, Inc. Kate Popova Contracts Administration Lead 610-285-1699 ekaterina.popova@nordicpharma.com Gail Feerrar Director Sales and Marketing 610-285-7152 gail.feerrar@nordicpharma.com Source: Nordic Pharma, Inc. View this news release online at:

Acquisition

14 Mar 2024

·www.prnewswire.com

Empower Aesthetics Highlights Recent Strategic Partnerships: Uplifting Businesses of Medical Aesthetic Industry Entrepreneurs

Private Equity-Backed Platform Pursues New Clinical Partnerships and Sparks Growth of Medical Aesthetics Industry Across the U.S. CHICAGO , March 14, 2024 /PRNewswire/ -- Empower Aesthetics ("Empower" or "the Company"), a national medical aesthetics platform, continues its fast-paced growth while at the same time seeking new clinical partnerships to build out the platform. Empower Aesthetics was formed in July 2023 by Shore Capital Partners ("Shore" or "Shore Capital"), a Chicago-based private equity firm focused on microcap investing. Under the leadership of Chief Executive Officer, Alyssa Rapp and Empower's Board of Directors, the Company has solidified four recent partnerships with leading medical aesthetics practices in key U.S. markets: DermaTouch RN Founded in 2006 by Renee Moschitto, Registered Nurse and Founder of the Texas Association of Aesthetic Nurses, DermaTouch RN is a state-of-the-art aesthetic and wellness center that offers minimally invasive medical treatments. Ranked as a top 20 provider of Botox and Juvederm in the country, DermaTouch is consistently recognized as an "Advanced Injector" site and is one of the largest and highest rated providers of Botox, Juvederm and CoolSculpting® ELITE in the Houston area. AWSkin Co. Founded in 2008 in Murfreesboro, Tennessee by Board Certified Nurse Practitioner Amy Hatcher, AWSkin Co. is a medical spa and wellness center offering cosmetic injectables, advanced skincare services, wellness therapies and more. AWSkin Co. has three locations in Cool Springs, Franklin, and Murfreesboro, Tennessee. The Artistry of Face Founded in 2016 by Nurse Practitioner Kelly Heffernan, Artistry of Face offers neurotoxin procedures, dermal filler procedures, body contouring, energy and light-based treatments, as well as a wide range of facial treatments. The practice currently operates out of locations in Albany and Glen Falls, New York. BCRN Aesthetics Founded in 2012 as Rejuviface by Bri and rebranded as BCRN Aesthetics in 2017 by Registered Nurse and Galderma Aesthetic Injector Network (GAIN) Trainer Bri Collins, BCRN Aesthetics is home to Houston's leading advanced aesthetic injectors. The practice's always-evolving knowledge of aesthetics, combined with their unwavering dedication to exceptional customer service and top-tier medical training, makes it one of the most sought-after med spas in the Houston area. "We are committed to building a constellation of clinical partners that are amongst the brightest stars in the space, who deliver and uphold the highest standards of clinical excellence," said Rapp. "The prospect of establishing additional clinical partnerships in the immediate future is a source of great enthusiasm for both me, our executive leadership team and Empower's Board of Directors." Empower Aesthetics is actively pursuing an acquisition strategy, looking for like-minded, growth-oriented entrepreneurs in aesthetics to join a trusted network of clinical leaders, share best practices and deliver superior clinical outcomes. By implementing strategic and operational initiatives intended to elevate the Company's partners, Empower Aesthetics helps clinical leaders grow their businesses, achieve their financial goals, streamline operations and connect with new clients. This private equity-backed support supplies Empower's partners with the resources needed to help grow their businesses, invest in employees, fine-tune operations and see more patients. To learn more about Empower Aesthetics, please visit , or email [email protected]. About Empower Aesthetics Empower Aesthetics is a national aesthetics platform that provides the tools, support and strategy to empower aesthetic owners and practices to reach new heights while maintaining the highest quality of care. With corporate presence in Chicago, Illinois and Austin, Texas, Empower is looking for providers with whom to partner and grow. To learn more about Empower Aesthetics, please visit , or email [email protected]. About Shore Capital Partners Shore Capital, a Chicago-based private equity firm with an office in Nashville, is an investor in microcap companies in the Healthcare, Food and Beverage, Business Services, Industrial, and Real Estate industries. Shore's strategy is to support management partners to grow faster with less risk, through access to capital; world-class board and operational resources; and unmatched networking, development, and shared learnings across the portfolio. From 2020-2023 Shore received recognition from Inc. Magazine as a 4x Top Founder-Friendly Investor and by Pitchbook for being the global leader in private equity total deal volume. Shore targets investments in proven, successful companies with superior management teams, stable cash flow, and significant potential to grow through industry consolidation and organic growth to generate value for shareholders. Shore has approximately $6 billion of assets under management through various investment vehicles. For more information, please visit . Media Contact: Alec Miszuk | Fishman PR | [email protected] | (630) 484-0797 SOURCE Empower Aesthetics

Executive ChangeAcquisition

100 Deals associated with Hyaluronic acid

External Link

KEGG	Wiki	ATC	Drug Bank
D08043	Hyaluronic acid	-	DB08818

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Osteoarthritis, Knee	Phase 2	-	-	01 Jun 2021
Alpha 1-Antitrypsin Deficiency	Phase 1	-	Actelion Pharmaceuticals Ltd.	-
Asthma	Phase 1	-	Actelion Pharmaceuticals Ltd.	-

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05130814 (RISE_UP, CTgov)	Not Applicable	Pressure Ulcer	48	bandage+zinc+hyaluronic acid gauze plus polyurethane foam+hyaluronic acid sodium salt+metallic silver (Control Group)	xldpugwven(pffjczhdaf) = uhtskzynqa jhrosakpiq (zlphknxoau, lfnuqqeepj - tvxqwosozb) View more	-	28 Jan 2025
				bandage+zinc+hyaluronic acid gauze plus polyurethane foam+hyaluronic acid sodium salt+metallic silver (EmoLED Group)	xldpugwven(pffjczhdaf) = wbbqnlffun jhrosakpiq (zlphknxoau, pyaafyhdbh - uzuzqovvef) View more
ASTRO2024	Not Applicable	Prostatic Cancer	-	Non-Animal Stabilized Hyaluronic Acid (NASHA) (NASHA rectal spacer)	xmzsnwzauw(vegkzkwmim) = iwqiikttze dneqrlcecj (bmvnjxlbuj ) View more	-	01 Oct 2024
				Non-Animal Stabilized Hyaluronic Acid (NASHA) (No spacer)	xmzsnwzauw(vegkzkwmim) = ahtfsofrra dneqrlcecj (bmvnjxlbuj ) View more
NCT03460158 (CTgov)	Phase 4	-	101	Restylane-L®	vzhelkpufo(kapfweapdx) = bxpprhuobk orbyewyupn (dgoplarxln, ypsseojpot - ayosqjqoxq) View more	-	27 Sep 2024
NCT06178367 (Pubmed)	Phase 3	Asteatosis cutis hyaluronic acid	36	Low Molecular Weight Hyaluronic Acid (LMWHA)	xxshklgzuk(vflesrmjnw) = ytvzcbfbri iadablpeke (khbcbtjzgk )	Positive	03 Jun 2024
				High Molecular Weight Hyaluronic Acid (HMWHA)	xxshklgzuk(vflesrmjnw) = aplddiukvx iadablpeke (khbcbtjzgk )
Abstract P3-07-26 (SABCS2023)	Not Applicable	Breast Cancer ER-positive \| triple-negative	-	FCE-loaded PLGA nanoparticles	dhtxpytsfn(ogohlfaden) = hfyjaxdpix meshgwwtcz (pvuvqvdspo ) View more	Positive	01 Mar 2023
EADV2022	Not Applicable	Blepharoptosis	20	hyaluronic acid	gaztvlvynw(hjgafyubii) = ohbqhxhxmr bubbwhsppm (cctoqsrdog ) View more	-	07 Sep 2022
				Pneumatic injection of Hyaluronic Acid	gaztvlvynw(hjgafyubii) = xhlpfkntjs bubbwhsppm (cctoqsrdog ) View more
EADV2022	Not Applicable	-	-	Cross-linked HA gel 20mg/ml	xcbpgebzsu(zahjandxhf) = 3% aqxwjwhxvg (zeltroxfvn ) View more	-	07 Sep 2022
DDW2022	Not Applicable	Weight Loss	-	CONJUGATED LINOLEIC ACID (CLA), COLLAGEN, AND HYALURONIC ACIDConjugated Linoleic Acid (CLA), COLLAGEN, AND HYALURONIC ACID (Conjugated Linoleic Acid (CLA))	sktqtkmvuf(skzjmoojdo) = zrcivdspfd mfytigdqag (omsvqieypj ) View more	-	24 May 2022
IRCT2015081723666N1 (Pubmed \| BMC Womens Health)	Phase 3	Endometrial Carcinoma	50	Hyaluronic acid gel (Ovarian suspension)	jjljkbhgrq(ykngxskhzv) = ddznpprbyd oqsvftlpio (pjlzdtqrnn ) View more	-	11 Feb 2022
				Hyaluronic acid gel	jjljkbhgrq(ykngxskhzv) = akhgcdfjkg oqsvftlpio (pjlzdtqrnn ) View more
EULAR2021	Not Applicable	Osteoarthritis, Knee	160	Low molecular weight (LMW) HA	cunwzhkvob(oiesjjljki) = improvement was detected by 1 month in 84.3% of cases, and remained until the end of the study in 71.1% of patients ecscmezvfi (ncwkidukea )	-	02 Jun 2021
				Medium molecular weight (MMW) HA

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