A Phase I Open-Label, Dose-escalation Trial of Tumor Necrosis Factor Alpha and Interleukin-2 Coding Oncolytic Adenovirus (TILT-123) in Combination With Pembrolizumab in Patients With Immune Checkpoint Inhibitor Refractory Non-Small Cell Lung Cancer

This is an open label, Phase 1, dose escalation trial evaluating the safety of oncolytic adenovirus TILT-123 in combination with Pembrolizumab in patients with immune checkpoint inhibitor refractory non-small cell lung cancer.

Start Date20 Mar 2024

Sponsor / Collaborator

TILT Biotherapeutics Oy

[+1]

NCT05222932 / RecruitingPhase 1

A Phase I Open-Label, Dose-escalation Clinical Trial of Tumor Necrosis Factor Alpha and IL-2 Coding Oncolytic Adenovirus TILT-123 and Avelumab in Solid Tumor Patients (Melanoma and SCCHN) Refractory to or Progressing After Anti-PD(L)1

This is a phase 1, dose-escalation trial evaluating the safety of oncolytic adenovirus TILT-123 in combination with avelumab in patients with advanced solid tumors refractory to or progressing after anti-PD(L)1.

Start Date08 Mar 2023

Sponsor / Collaborator

TILT Biotherapeutics Oy

NCT05271318 / RecruitingPhase 1

A Two-part, Phase I/Ib, Open-Label, Dose-escalation Trial of Tumor Necrosis Factor Alpha and Interleukin-2 Coding Oncolytic Adenovirus (TILT-123) in Combination With Pembrolizumab (Phase I Part) and Pembrolizumab and Pegylated Liposomal Doxorubicin (Phase Ib Part) in Patients With Platinum Resistant or Refractory Ovarian Cancer.

This is an open-label, phase 1, dose-escalation, multicenter and multinational trial evaluating the safety of oncolytic adenovirus TILT-123 in combination with Pembrolizumab, or Pembrolizumab and Pegylated Liposomal Doxorubicin in patients with platinum resistant or refractory ovarian cancer.

Start Date17 May 2022

Sponsor / Collaborator

TILT Biotherapeutics Oy

[+1]

100 Clinical Results associated with Igrelimogene litadenorepvec

100 Translational Medicine associated with Igrelimogene litadenorepvec

100 Patents (Medical) associated with Igrelimogene litadenorepvec

Literatures (Medical) associated with Igrelimogene litadenorepvec

31 Dec 2023·Oncoimmunology

Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer

Article

Author: Räsänen, Jari ; Hemminki, Otto ; Aaltonen, Eero ; Quixabeira, Dafne C A ; Havunen, Riikka ; Borenius, Kristian ; Mäyränpää, Mikko I ; Lähdeniemi, Iris A K ; Sutinen, Eva ; Santos, Joao M ; Pakola, Santeri ; Arias, Victor ; Clubb, James H A ; Cervera-Carrascon, Victor ; Hemminki, Akseli ; Verschuren, Emmy W ; Kudling, Tatiana V ; Kanerva, Anna ; Sorsa, Suvi ; Ilonen, Ilkka ; Heiniö, Camilla

Lung cancer remains among the most difficult-to-treat malignancies and is the leading cause of cancer-related deaths worldwide. The introduction of targeted therapies and checkpoint inhibitors has improved treatment outcomes; however, most patients with advanced-stage non-small cell lung cancer (NSCLC) eventually fail these therapies. Therefore, there is a major unmet clinical need for checkpoint refractory/resistant NSCLC. Here, we tested the combination of aPD-1 and adenovirus armed with TNFα and IL-2 (Ad5-CMV-mTNFα/mIL-2) in an immunocompetent murine NSCLC model. Moreover, although local delivery has been standard for virotherapy, treatment was administered intravenously to facilitate clinical translation and putative routine use. We showed that treatment of tumor-bearing animals with aPD-1 in combination with intravenously injected armed adenovirus significantly decreased cancer growth, even in the presence of neutralizing antibodies. We observed an increased frequency of cytotoxic tumor-infiltrating lymphocytes, including tumor-specific cells. Combination treatment led to a decreased percentage of immunosuppressive tumor-associated macrophages and an improvement in dendritic cell maturation. Moreover, we observed expansion of the tumor-specific memory T cell compartment in secondary lymphoid organs in the group that received aPD-1 with the virus. However, although the non-replicative Ad5-CMV-mTNFα/mIL-2 virus allows high transgene expression in the murine model, it does not fully reflect the clinical outcome in humans. Thus, we complemented our findings using NSCLC ex vivo models fully permissive for the TNFα and IL-2- armed oncolytic adenovirus TILT-123. Overall, our data demonstrate the ability of systemically administered adenovirus armed with TNFα and IL-2 to potentiate the anti-tumor efficacy of aPD-1 and warrant further investigation in clinical trials.

01 Jun 2020·Molecular therapy oncolyticsQ2 · MEDICINE

Comparison of Clinically Relevant Oncolytic Virus Platforms for Enhancing T Cell Therapy of Solid Tumors

Q2 · MEDICINE

ArticleOA

Author: Zafar, Sadia ; Santos, Joao M ; Quixabeira, Dafne C A ; Havunen, Riikka ; Koivula, Teija ; Lumen, Dave ; Hemminki, Akseli ; Anttila, Marjukka ; Kanerva, Anna ; Garcia-Horsman, Arturo ; Vaha, Marjo ; Sorsa, Suvi ; Heiniö, Camilla ; Cervera-Carrascon, Victor ; Airaksinen, Anu J ; Clubb, James H A ; Kutvonen, Emma ; Hukkanen, Veijo ; Siurala, Mikko

Despite some promising results, the majority of patients do not benefit from T cell therapies, as tumors prevent T cells from entering the tumor, shut down their activity, or downregulate key antigens. Due to their nature and mechanism of action, oncolytic viruses have features that can help overcome many of the barriers currently facing T cell therapies of solid tumors. This study aims to understand how four different oncolytic viruses (adenovirus, vaccinia virus, herpes simplex virus, and reovirus) perform in that task. For that purpose, an immunocompetent in vivo tumor model featuring adoptive tumor-infiltrating lymphocyte (TIL) therapy was used. Tumor growth control (p < 0.001) and survival analyses suggest that adenovirus was most effective in enabling T cell therapy. The complete response rate was 62% for TILs + adenovirus versus 17.5% for TILs + PBS. Of note, TIL biodistribution did not explain efficacy differences between viruses. Instead, immunostimulatory shifts in the tumor microenvironment mirrored efficacy results. Overall, the use of oncolytic viruses can improve the utility of T cell therapies, and additional virus engineering by arming with transgenes can provide further antitumor effects. This phenomenon was seen when an unarmed oncolytic adenovirus was compared to Ad5/3-E2F-d24-hTNFa-IRES-hIL2 (TILT-123). A clinical trial is ongoing, where patients receiving TIL treatment also receive TILT-123 (ClinicalTrials.gov: NCT04217473).

01 Jan 2020·OncoimmunologyQ2 · MEDICINE

Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition

Q2 · MEDICINE

ArticleOA

Author: Havunen, Riikka ; Santos, Joao Manuel ; Zafar, Sadia ; Sorsa, Suvi ; Mildh, Markus ; Munaro, Eleonora ; Hemminki, Akseli ; Rannikko, Antti ; Järvinen, Petrus ; Quixabeira, Dafne C.A. ; Hemminki, Otto ; Anttila, Marjukka ; Kanerva, Anna ; Mirtti, Tuomas ; Siurala, Mikko ; Cervera-Carrascon, Victor ; Heiniö, Camilla ; Nisen, Harry

Checkpoint inhibitors have revolutionized cancer therapy and validated immunotherapy as an approach. Unfortunately, responses are seen in a minority of patients. Our objective is to use engineered adenoviruses designed to increase lymphocyte trafficking and cytokine production at the tumor, to assess if they increase the response rate to checkpoint inhibition, as these features have been regarded as predictive for the responses. When Ad5/3-E2F-d24-hTNFa-IRES-hIL2 (an oncolytic adenovirus coding for TNFa and IL-2, also known as TILT-123) and checkpoint inhibitors were used together in fresh urological tumor histocultures, a significant shift toward immune activity (not only tumor necrosis alpha and interleukin-2 but also interferon gamma and granzyme B) and increased T-cell trafficking signals (CXCL10) was observed. In vivo, our viruses enabled an anti-PD-L1 (a checkpoint inhibitor) delivering complete responses in all the treated animals (hazard ratios versus anti-PD-L1 alone 0.057 [0.007; 0.451] or virotherapy alone 0.067 [0.011; 0.415]). To conclude, when an engineered oncolytic adenovirus was utilized to modify the tumor microenvironment towards what meta-analyses have pointed as predictive markers for checkpoint inhibitory therapy, the response to them increased synergistically. Of note, key findings were confirmed in fresh patient-derived tumor explants.

News (Medical) associated with Igrelimogene litadenorepvec

28 May 2024

·www.biospace.com

TILT Biotherapeutics Presents Clinical Data on TILT-123 in Ovarian Cancer at ASCO 2024

Results reinforce potential to develop TILT-123 as a systemic therapy HELSINKI, Finland, May 28, 2024 (GLOBE NEWSWIRE) -- TILT Biotherapeutics (TILT), a clinical-stage biotechnology company developing cancer immunotherapies, announces that it will present two abstracts at the American Society of Clinical Oncology (ASCO) Annual Meeting 2024. Abstract (5562) demonstrates promising safety and efficacy data of TILT-123 in ovarian cancer patients, whilst abstract (2658) demonstrates the potential for TILT-123 as an intravenous therapy. Abstract (5562)* covers the results of a Phase I clinical trial of TILT-123 in combination with MSD’s (Merck & Co., Inc., Rahway, NJ, USA) anti-PD-1 therapy KEYTRUDA® (pembrolizumab), for the treatment of platinum-resistant or -refractory ovarian cancer, demonstrating the combination is safe and appears to induce disease control in a difficult-to-treat patient population. 14 patients (out of 15 enrolled) were evaluable for treatment response, with disease control achieved in 64.3%. Analysis of biological samples indicated the presence of TILT-123 and induction of T cells in injected and non-injected lesions. Long term survival was seen in some patients: Median progression free survival (PFS) and overall survival (OS) in all patients were 105 and 280 days. In patients with stable disease (SD) on day 92 by RECIST 1.1, median PFS was 174 days and median OS was 293 days. Abstract (2658) introduces the development of oncolytic adenovirus TILT-123 as an intravenous (IV) therapy. Results across three Phase I trials showed that IV delivery results in systemic tumor transduction and accumulation of lymphocytes at tumors. This means TILT-123 reached tumors, despite not being directly injected into them, and successfully triggered an immune system toward the cancer. The IV injection of TILT-123 results in persistence of the virus in peripheral blood for up to 7 days. Tumor transduction was observed in 75% of patients in three Phase I trials on day 8 post TILT-123 systemic administration. TILT Biotherapeutics’ founder and CEO, Akseli Hemminki, a cancer clinician who has personally treated hundreds of cancer patients with oncolytic viruses, said “This data presented at ASCO 2024 provides additional validation as we move forward in our clinical trials for patients with resistant or refractory ovarian cancer that have few other treatment options.” TILT-123, an oncolytic adenovirus armed with tumor necrosis factor alpha (TNFα) and interleukin-2 (IL-2), is designed to enhance the efficacy of T-cell therapies, including immune checkpoint blockade or adoptive cell transfer. TILT’s approach uses oncolytic viruses to selectively replicate in and lyse cancer cells, while simultaneously stimulating immune responses towards the tumor. References: Abstract (5562): Poster #433 presented 3 June at 09:00-12:00 Abstract (2658): Poster #137 presented 1 June at 09:00-12:00 *The work was supported by the Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense, in the amount of $2,098,194.00, through the Ovarian Cancer Research Program under Award No. HT9425-23-1-0988. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Assistant Secretary of Defense for Health Affairs or the Department of Defense. KEYTRUDA® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA. Notes to Editors About TILT Biotherapeutics TILT Biotherapeutics is a clinical-stage biotechnology company developing cancer therapeutics based on its proprietary oncolytic adenoviruses armed with molecules including cytokines that can activate T cells and destroy cancer cells. The company’s patented TILT® technology can be delivered intravenously, locoregionally, or intratumorally. It modifies the tumor microenvironment and has a broader systemic effect. By making cold tumors hot, it eliminates cancer’s ability to evade immune responses, thereby enhancing T-cell therapies such as immune checkpoint inhibitors, tumor infiltrating lymphocyte (TIL) therapy, and CAR T therapies. TILT’s lead asset, TILT-123 also known as Igrelimogene litadenorepvec, is a 5/3 chimeric serotype adenovirus armed with two human cytokines: TNF alpha and IL-2. About fifty patients have been treated in four international trials sponsored by the company with promising initial efficacy responses observed in some of the patients. The company’s pioneering approach has been recognized by industry leaders. It has two collaborations with MSD (Merck & Co., Inc., Rahway, NJ, USA) investigating TILT-123 in combination with KEYTRUDA® (pembrolizumab) in ovarian cancer (NCT05271318) and in refractory non-small cell lung cancer (NCT06125197). The company is also collaborating with Merck KGaA, Darmstadt, Germany, and investigating TILT-123 in combination with avelumab. Based in Helsinki, Finland, and with an office in Boston, the company was established over a decade ago as a spin-out from the University of Helsinki. It has funding from Lifeline Ventures, Finnish Industry Investment (TESI), angel investors, Business Finland, the European Innovation Council, and the U.S. Department of Defense. Media contacts TILT Biotherapeutics COO Aino Kalervo aino@tiltbio.com Scius Communications Katja Stout +447789435990 katja@sciuscommunications.com Daniel Gooch +447747875479 daniel@sciuscommunications.com

Clinical ResultPhase 1ImmunotherapyASCO

12 Apr 2024

·www.biospace.com

Vaccines, Next-Gen Approaches Target the Toughest Cancers: AACR

Pictured: Gloved hands amid a collage of cancer treatments/Taylor Tieden for BioSpace Parsing key trends from 7,200 abstracts on cancer-related research can be challenging—take it from someone who’s spent the past week trying to do it! But pretty quickly, a few key themes became apparent at the American Association for Cancer Research’s annual meeting. First and foremost, the programs presented are tackling difficult cancers with a high unmet need and a dire prognosis. Some of the presentations last weekend involved drug candidates targeting pancreatic cancer, for example. In 2023, the five-year survival rate for pancreatic cancer was just 12%, according to the American Cancer Society. Two presentations—one on Bristol Myers Squibb’s blockbuster immunotherapy Opdivo, the other on a messenger RNA vaccine in development by BioNTech and Genentech—showed promising signals. Opdivo’s trial, the first reported of a PD1 inhibitor in neoadjuvant pancreatic cancer, indicated that the drug may improve outcomes, while BioNTech and Genentech’s vaccine continued to show potential in a particularly difficult-to-treat form of the disease. This announcement also dovetailed with another prominent theme at AACR: the resurgence of cancer vaccines, which are also making inroads in advanced liver cancer, head and neck cancer, non-small cell lung cancer and glioblastoma. Glioblastoma is a particularly aggressive form of brain cancer that carries a 5-year survival rate of just 10%; patients typically survive between 15 and 18 months after being diagnosed. A Phase I study of Diakonos Oncology’s dendritic cell vaccine showed “substantially increased survival” in glioblastoma patients; 88% of patients remained alive a year after treatment, compared to a historical 53% of those on standard regimens. Other platforms and approaches also appear to be breaking through against difficult-to-treat cancers, though many of the results presented at AACR are still early stage. As anticipated, antibody-drug conjugates (ADCs) were a focus, with Vincerx Pharma presenting Phase I data in metastatic tumors and Merck and Kelun-Biotech reporting a potential survival benefit from their TROP2-directed ADC in gastric cancer. Several other modalities were also on display at AACR. Phase I data from Menlo Park, Calif.–based Synthekine, for example, showed that its α/β biased interleukin-2 (IL-2) partial agonist, STK-012, has thus far avoided the toxicities associated with IL-2 therapies while also demonstrating a “favorable” efficacy pro advanced solid tumors. And TILT Biotherapeutics reported that TILT-123, an oncolytic adenovirus armed with tumor necrosis factor alpha and IL-2, “demonstrated signs of efficacy” when combined with Merck’s Keytruda in a Phase I trial in patients with platinum-resistant and refractory ovarian cancer. Another therapy that drew attention at the meeting was AstraZeneca’s next-generation poly-ADP ribose polymerase 1 (PARP1) selective inhibitor, which experts are hopeful can negate some of the toxicities caused by drugs that inhibit both PARP1 and PARP2. Timothy Yap, vice president and head of clinical development in the Therapeutics Discovery Division at The University of Texas MD Anderson Cancer Center, noted in his presentation of the positive Phase I/II trial data that there is a “great opportunity” to combine a selective PARP1 inhibitor with other therapies. This was a point also made by David Weinstock, vice president of discovery oncology at Merck, who in March told BioSpace that we are moving toward a future “where we have enough medications that each work individually and have minimal side effects so that we can create even larger combinations, which offer the most benefit to people.” As a science journalist, it’s easy to get bogged down in the data, the results and biggest trends (ADCs for all!) and forget the human face of cancer. As a human being, it’s easy to get depressed by improvements that might seem incremental, but an additional six months can mean another birthday, another anniversary or the birth of another grandchild. Elevation Oncology CSO David Dornan told me that solid cancers “are almost equally as hard and different in their own right.” But progress is being made. In 2023, the five-year survival rate for pancreatic cancer increased by one percentage point from the previous year, marking the second year in a row survival has increased. Overall, the cancer death rate in the U.S. has declined by 33% since 1991. I, for one, am looking forward to reading about the next advances at the American Society of Clinical Oncology’s annual meeting in June. Heather McKenzie is a senior editor at BioSpace. You can reach her at heather.mckenzie@biospace.com. Also follow her on LinkedIn.

Phase 1ASCOVaccineAACRClinical Result

10 Apr 2024

·www.biospace.com

TILT Biotherapeutics Presents Clinical Data on TILT-123 in Combination with KEYTRUDA® (pembrolizumab) for Ovarian Cancer at AACR 2024

Results Reveal Mechanism of Action and Correlative Analyses Data HELSINKI, Finland, April 10, 2024 (GLOBE NEWSWIRE) -- TILT Biotherapeutics (TILT), a clinical-stage biotechnology company developing cancer immunotherapies presented promising preliminary safety and efficacy data from their ongoing Phase I clinical trial (NCT05271318) in platinum resistant or refractory ovarian cancer patients at the American Association for Cancer Research (AACR) Annual Meeting 2024. TILT-123 in combination with MSD’s (a tradename of Merck & Co., Inc., Rahway, NJ, USA) anti-PD-1 therapy KEYTRUDA® (pembrolizumab) was safe and demonstrated signs of efficacy in both platinum resistant and refractory ovarian cancer patients. Analysis of biological samples revealed insights into mechanism of action, including an immunological pro predictive of clinical response. The study results were based on 15 patients who received intratumoral or intraperitoneal doses of TILT-123 therapy in combination with intravenous doses of pembrolizumab in an open label phase I clinical trial using a standard 3+3 dose escalation scheme. Notably, disease control was seen in 71% of evaluable patients including one long lasting partial response in a patient with mucinous carcinoma. Tumor size reductions and significant immunomodulation were seen in injected and non-injected tumors, indicating the potential for a systemic response. The results demonstrated that a strong humoral response and increased presence of IgE+ plasma cells significantly correlated with clinical response and overall survival. They also revealed insights into the mechanism of action of the combination therapy. TILT Biotherapeutics’ founder and CEO, Akseli Hemminki, a cancer clinician who has personally treated hundreds of cancer patients with oncolytic viruses, said “We are excited to see the latest ongoing positive potential to bring a more effective treatment to patients with refractory ovarian cancer that have few other treatment options. Importantly, an immune response and reduction in tumour size was seen from intratumoral injections of the combination therapy as well as those away from the tumour site, which demonstrates the potential for a systemic response.” TILT-123, an oncolytic adenovirus armed with tumor necrosis factor alpha (TNFα) and interleukin-2 (IL-2), is designed to enhance the efficacy of T-cell therapies, including immune checkpoint blockade or adoptive cell transfer for re-invigoration of the tumor microenvironment. TILT’s approach uses oncolytic viruses to selectively replicate in and lyse cancer cells, while simultaneously stimulating immune responses towards the tumor. The results presented at AACR 2024, along with data from other ongoing trials, underscore the promise of TILT-123 as a novel cancer therapy. Continued clinical evaluation, including ongoing trials (NCT04695327, NCT04217473, NCT06125197, and NCT05222932), will further elucidate the therapeutic potential of TILT-123 across various solid cancer types. Reference: Immunological activity of oncolytic adenovirus encoding TNFα and IL-2 (TILT-123) in combination with pembrolizumab in platinum resistant or refractory ovarian cancer patients KEYTRUDA® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA. Notes to Editors About TILT Biotherapeutics TILT Biotherapeutics is a clinical-stage biotechnology company developing cancer therapeutics based on its proprietary oncolytic adenoviruses armed with molecules including cytokines that can activate T cells and destroy cancer cells. The company’s patented TILT® technology can be delivered intravenously, locoregionally, or intratumorally. It modifies the tumor microenvironment and has a broader systemic effect. By making cold tumors hot, it eliminates cancer’s ability to evade immune responses, thereby enhancing T-cell therapies such as immune checkpoint inhibitors, tumor infiltrating lymphocyte (TIL) therapy, and CAR T therapies. TILT’s lead asset, TILT-123 also known as Igrelimogene litadenorepvec, is a 5/3 chimeric serotype adenovirus armed with two human cytokines: TNF alpha and IL-2. About fifty patients have been treated in four international trials sponsored by the company with promising initial efficacy responses observed in some of the patients. The company’s pioneering approach has been recognized by industry leaders. It has two collaborations with MSD, a tradename of Merck & Co., Inc., investigating TILT-123 in combination with KEYTRUDA® (pembrolizumab) in ovarian cancer (NCT05271318) and in refractory non-small cell lung cancer (NCT06125197). The company is also collaborating with Merck KGaA, Darmstadt, Germany, and investigating TILT-123 in combination with avelumab. Based in Helsinki, Finland, and with an office in Boston, the company was established over a decade ago as a spin-out from the University of Helsinki. It has funding from Lifeline Ventures, Finnish Industry Investment (TESI), angel investors, Business Finland, the European Innovation Council, and the U.S. Department of Defense. Media contacts TILT Biotherapeutics COO Aino Kalervo aino@tiltbio.com Scius Communications Katja Stout +447789435990 katja@sciuscommunications.com Daniel Gooch +447747875479 daniel@sciuscommunications.com

Clinical ResultPhase 1ImmunotherapyAACR

100 Deals associated with Igrelimogene litadenorepvec

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Indication	Highest Phase	Country/Location	Organization	Date
Non-Small Cell Lung Cancer	Phase 1	US	TILT Biotherapeutics Oy	26 Sep 2022
Melanoma	Phase 1	FI	TILT Biotherapeutics Oy	01 Jul 2022
Squamous Cell Carcinoma of Head and Neck	Phase 1	FI	TILT Biotherapeutics Oy	01 Jul 2022
Ovarian Cancer	Phase 1	US	TILT Biotherapeutics Oy	17 May 2022
Ovarian Cancer	Phase 1	FI	TILT Biotherapeutics Oy	17 May 2022
Metastatic melanoma	Phase 1	DK	TILT Biotherapeutics Oy	26 Feb 2020
Metastatic melanoma	Phase 1	FR	TILT Biotherapeutics Oy	26 Feb 2020
Lung Cancer	Phase 1	-	TILT Biotherapeutics Oy	-

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04695327 \| NCT05271318 \| NCT04217473 (TILT-123, ASCO2024)	Phase 1	-	52	TILT-123	topkaqtmfa(setopdysbo) = increased in the patients´ serum sjcvnsgiqq (mgbppykcjg )	Positive	24 May 2024
NCT05271318 (AACR2024) Manual	Phase 1	Ovarian Cancer	15	TILT-123+pembrolizumab	nxjdheddui(jfcppxuaxq) = not observed bzvmmachoz (jvmhmglpwr ) View more	Positive	05 Apr 2024
NCT04695327 (TUNIMO, Pubmed)	Phase 1	Solid tumor	20	TILT-123	tggazpwkkg(ijpydhtiff) = okneijqxek gwqckwsxcq (ewbhhpxbup )	Positive	28 Mar 2024
NCT04217473 (ESMO_IO 12023 \| ESMO_IO 22023) Manual	Phase 1	Melanoma	16	TILT-123	qapuqyocay(kprrzogdjm) = The most frequently reported adverse events (AEs) related to TILT-123 were fever (63%) and pain at the injection site (44%) while most frequent AEs related to TIL therapy were fever (50%) and chills (24%). zyqecrwygr (wlxupunrtm )	Positive	06 Dec 2023
NCT04695327 (TUNIMO , SITC2023) Manual	Phase 1	Solid tumor	20	TILT-123	itrdxdnqxq(qwczuhhgdw) = not observed rroiyahkmg (zswgagziaf ) View more	Positive	31 Oct 2023
NCT04695327 \| NCT05222932 \| NCT05271318 \| NCT04217473 (SITC2022) Manual	Phase 1	Solid tumor	18	TILT-123	zsorruocqm(roaqqqpylt) = ywfpuxhvth kiknotbtno (vaubzhspbk )	Positive	01 Nov 2022

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