PARP inhibitors(Poly (ADP-Ribose) polymerase inhibitors), PARP1 inhibitors(Poly (ADP-Ribose) polymerase 1 inhibitors), PARP2 inhibitors(Poly (ADP-Ribose) Polymerase 2 inhibitors)

Therapeutic Areas

NeoplasmsSkin and Musculoskeletal DiseasesUrogenital Diseases+ [7]

Active Indication

Breast CancerBRCA Mutation Castration-Resistant Prostate CancerMetastatic castration-resistant prostate cancer+ [30]

Inactive Indication

Advanced Endometrial CarcinomaChildhood Malignant Solid NeoplasmChronic Lymphocytic Leukemia+ [15]

Originator Organization

BioMarin Pharmaceutical, Inc.

Active Organization

Pfizer Inc.Pfizer Europe MA EEIG

PF Consumer Healthcare Canada ULC

+ [5]

Inactive Organization

MediVation, Inc.

Calithera Biosciences, Inc.

Drug Highest PhaseApproved

First Approval Date

US (16 Oct 2018),

Germline BRCA-mutated, HER2-negative metastatic breast cancer

RegulationPriority Review (US)

Structure

Molecular FormulaC26H22F2N6O4S

InChIKeyQUQKKHBYEFLEHK-QNBGGDODSA-N

CAS Registry1373431-65-2

View All Structures (2)

120

Clinical Trials associated with Talazoparib Tosylate

NCT04982848 / Not yet recruitingNot Applicable

A Prospective, Single-arm, Open-label, Non-interventional, Multi-centre, Post Marketing Surveillance (PMS) Study of Talzenna(Registered)

Talzenna will be approved for the treatment of gBRCA advanced breast cancer in Korea. In accordance with the Standards for Re-examination of New Drug, it is required to conduct a PMS. Post marketing surveillance is required to determine any problems or questions associated with Talzenna after marketing in Korea, with regard to the following clauses under conditions of general clinical practice. Therefore, through this study, effectiveness and safety of Talzenna will be observed.

Start Date31 Dec 2024

Sponsor / Collaborator

Pfizer Inc.

CTRI/2024/10/076008 / Not yet recruitingNot ApplicableIIT

Retrospective observational study of safety and efficacy of Talazoparib in BRCA1/2 or PALB2 mutation breast cancer. - Nil

Start Date10 Nov 2024

Sponsor / Collaborator-

NCT05873192 / Not yet recruitingPhase 2IIT

Presurgical Phase II Study of Talazoparib in Combination With Enzalutamide in de Novo Metastatic to Lymph Nodes Prostate Cancer

To learn about the effectiveness of adding talazoparib to the standard of care treatment combination of androgen ablation therapy (hormone therapy, also known as ADT) and enzalutamide in patients with prostate cancer that has spread into the lymph nodes.

Start Date30 Sep 2024

Sponsor / Collaborator

The University of Texas MD Anderson Cancer Center

100 Clinical Results associated with Talazoparib Tosylate

100 Translational Medicine associated with Talazoparib Tosylate

100 Patents (Medical) associated with Talazoparib Tosylate

486

Literatures (Medical) associated with Talazoparib Tosylate

01 Dec 2024·European Journal of Medicinal Chemistry

Isoxazole compounds: Unveiling the synthetic strategy, in-silico SAR & toxicity studies and future perspective as PARP inhibitor in cancer therapy

Review

Author: Malik, Udita ; Pal, Dilipkumar

Latest developments in cancer treatment have shed a light on the crucial role of PARP inhibitors that enhance the treatment effectiveness by modifying abnormal repair pathways. PARP inhibitors, such as Olaparib, Rucaparib, Niraparib, and Talazoparib have been approved in a number of cancers including BRCA 1/BRCA2 associated malignancies although there are many difficulties as therapeutical resistance. Besides the conventional synthetic drugs, natural compounds such as flavones and flavonoids have been found to be PARP inhibitors but only in preclinical studies. Isoxazole is very important class of potential candidates for medicinal chemistry with anti-cancer and other pharmacological activities. At present, there are no approved PARP inhibitors of isoxazole origin but their ability to hit many pathways inside the cancer cells points out on its importance for future treatments design. In drug development, isoxazoles are helpful because of the molecular design flexibility that may be enhanced using various synthetic approaches. This review highlights the molecular mechanisms of PARP inhibition, importance of isoxazole compounds and present advances in their synthetic strategies that demonstrate promise for these agents as new anticancer drugs. It emphasizes that isoxazole-based PARP inhibitors compounds could be novel anti-cancer drugs. Through this review, we hope to grow a curiosity in additional explorations of isoxazole-based PARP inhibitors and their applications in the trends of novel insights towards precision cancer therapy.

01 Dec 2024·European Journal of Cancer

Talazoparib plus enzalutamide in metastatic castration-resistant prostate cancer: Safety analyses from the randomized, placebo-controlled, phase III TALAPRO-2 study

Article

Author: Zschäbitz, Stefanie ; Oldenburg, Jan ; De Giorgi, Ugo ; Azad, Arun A. ; Saad, Fred ; Fizazi, Karim ; DeAnnuntis, Liza ; Dunshee, Curtis ; Carles, Joan ; Jones, Robert J. ; Matsubara, Nobuaki ; Shore, Neal D. ; Shore, Neal D ; Agarwal, Neeraj ; Azad, Arun A ; Jones, Robert J ; Zielinski, Michael A. ; Fong, Peter C.C. ; Zielinski, Michael A ; Fay, Andre P ; Fay, Andre P. ; Fong, Peter C C ; Di Santo, Nicola ; Joung, Jae Young ; Lin, Xun

BACKGROUNDThis detailed analysis further characterizes the safety profile of talazoparib plus enzalutamide in the ongoing randomized, phase III TALAPRO-2 study in patients with metastatic castration-resistant prostate cancer (mCRPC). In both the all-comers and homologous recombination repair (HRR)-deficient populations, talazoparib plus enzalutamide significantly improved radiographic progression-free survival compared with placebo plus enzalutamide.METHODSThe talazoparib plus enzalutamide safety populations in TALAPRO-2 included 398 patients from cohort 1 (all-comers, unselected for HRR gene alterations) and 198 patients from the combined HRR-deficient population (patients from the all-comers population with HRR gene alterations plus subsequently enrolled patients with HRR gene alterations; cohort 2). Patients received talazoparib 0.5 mg (0.35 mg, moderate renal impairment) and enzalutamide 160 mg once daily. Safety analyses evaluated common treatment-emergent adverse events (TEAE), their type, severity, timing, seriousness, and relationship to study treatment.RESULTSIn the all-comers (n = 398) and HRR-deficient populations (n = 198), all-cause grade 3/4 (G3/4) TEAEs with talazoparib plus enzalutamide were reported in 71.9 % and 66.2 % of patients, respectively. Most common G3/4 hematologic TEAEs were anemia (46.7 % and 40.9 %, respectively), neutropenia (18.3 % and 18.7 %), and thrombocytopenia (7.3 % and 7.1 %). Median time to event was 3.3 and 3.3 months for G3/4 anemia, 2.3 and 2.3 months for G3/4 neutropenia, and 2.3 and 1.5 months for G3/4 thrombocytopenia. Maximum hemoglobin reduction occurred after 13 and 15 weeks of treatment. 18.8 % and 10.1 % of patients discontinued talazoparib. TEAEs were managed with dose interruption (62.1 % and 57.6 %), reduction (52.8 % and 52.0 %), hematologic supportive care (13.1 % and 10.6 %), and packed red blood cell transfusions (39.2 % and 35.9 %).CONCLUSIONTalazoparib plus enzalutamide had a generally manageable safety profile in patients with mCRPC within the all-comers and the HRR-deficient populations.CLINICALTRIALSGOV IDENTIFIERNCT03395197.

01 Nov 2024·Expert Opinion on Drug Safety

PARP inhibitor-related acute renal failure: a real-world study based on the FDA adverse event reporting system database

Article

Author: Ren, Xiayang ; Wang, Yanfeng ; Sun, Ping

BACKGROUNDCurrent clinical trial data on PARP inhibitors (PARPis)-related acute renal failure (ARF) are not entirely representative of real-world situations. Therefore, in this study, the US Food and Drug Administration Adverse Event Reporting System (FAERS) was used to evaluate PARPis-related ARF.RESEARCH DESIGN AND METHODSData were obtained from 1 January 2015, to 30 September 2023. ARF event reports were analyzed based on four algorithms. The time-to-onset (TTO) and clinical outcomes of PARPis-associated ARF were assessed.RESULTSThe total included cases were 2726. Significant signals were observed for olaparib, niraparib, and rucaparib (reporting odds ratio (ROR): 1.62, 95% confidence interval (CI): 1.49-1.78, 1.25, 95% CI: 1.19-1.32 and 1.59, 95% CI: 1.47-1.72 respectively). The median TTO of ARF onset was 57, 36, and 85 days for olaparib, niraparib, and rucaparib, respectively. The proportion of deaths with olaparib (9.88%) was significantly higher than for niraparib (2.52%) and rucaparib (2.94%) (p < 0.005). The proportion of life-threatening adverse events associated with niraparib (4.89%) was significantly higher than for rucaparib (0.98%) (p < 0.005).CONCLUSIONSARF and PARPi were related, with the exception of talazoparib. More emphasis should be given to PARPis-related ARF due to the high proportion of serious AEs and delayed adverse reactions.

News (Medical) associated with Talazoparib Tosylate

14 Oct 2024

·pmlive.com

Pfizer shares positive phase 3 results for Talzenna combination in prostate cancer

Pfizer has announced positive overall survival (OS) results from a late-stage study of its prostate cancer combination treatment. The phase 3 TALAPRO-2 trial has been evaluating the drugmaker’s PARP inhibitor Talzenna (talazoparib) in combination with its Astellas-partnered androgen receptor pathway inhibitor (ARPI) Xtandi (enzalutamide) in patients with metastatic castration-resistant prostate cancer (mCRPC). Results showed a statistically significant and clinically meaningful OS improvement for patients receiving the combination in the ‘all-comers’ cohort, as well as those with homologous recombination repair (HRR) gene-mutated mCRPC, compared to Xtandi alone. Talzenna plus Xtandi is now the first and only PARP inhibitor/ARPI combination to significantly improve survival in mCRPC patients regardless of mutation status, noted Roger Dansey, Pfizer’s chief development officer, oncology. The clinically meaningful improvement in radiographic progression-free survival from the prior primary analysis of the trial was also maintained in both cohorts, and the safety profile of the combination was generally consistent with the known safety profile of each drug. Prostate cancer is the second most common cancer in men worldwide, with an estimated 1.4 million new cases diagnosed in 2022. Up to 20% of patients develop mCRPC, a form of the disease that has spread beyond the prostate gland and has progressed despite medical or surgical treatment to lower testosterone, within five to seven years of diagnosis. Talzenna plus Xtandi was approved by the US Food and Drug Administration in June 2023 for use in adults with HRR gene-mutated mCRPC. The combination was also approved by the European Commission in January 2024 to treat mCRPC in adults for whom chemotherapy is not clinically indicated. The new data from TALAPRO-2 will now be shared with global health authorities to support potential label expansion. Global lead investigator for the trial Neeraj Agarwal, Huntsman Cancer Institute, University of Utah, said: “These OS results indicate potentially practice-changing efficacy for Talzenna in combination with Xtandi for men with mCRPC. “mCRPC is the most advanced and aggressive stage of the disease, and the TALAPRO-2 results provide much-needed hope to patients who remain in high unmet need for effective treatment options.”

Clinical ResultPhase 3Drug Approval

11 Oct 2024

·www.biopharmadive.com

FDA clears Roche breast cancer drug; Turnstone lays off 60% of staff

Today, a brief rundown of news from Roche and Turnstone Biologics, as well as updates from Sanofi, Pfizer and Flagship Pioneering that you may have missed.Turnstone Biologics will lay off about 60% of its workforce and trim its pipeline in a bid to focus on a cancer cell therapy program in human testing, the company announced Friday. Through the restructuring, Turnstone will deprioritize preclinical work and put resources into a cell therapy in a Phase 1 trial for a variety of solid tumors. An update on the study is expected next year, while the restructuring moves will enable Turnstone to operate through the second quarter of 2026. Turnstoneraised $80 million in an initial public offering last year, but shares have lost nearly all of their value since. Ben FidlerThe Food and Drug Administration on Thursday approved a new Roche drug for breast cancer.Called Itovebi, the drug has been cleared for use with PfizersIbrance and endocrine therapy in people whose HR-positive, HER2-negative breast tumors have a mutation called PIK3CA. Itll compete for market share with Novartis Piqray, another medicine targeting PIK3CA mutations.Itovebi is one of five drugs Roche aims to add to its portfolio of breast cancer treatments, which already includes the targeted therapies Herceptin, Perjeta and Kadcyla. Jonathan GardnerVaccine developer Gritstone bio has filed for bankruptcy. The company said Thursday its in discussions with a party that would act as a potential buyer or plan sponsor, and should have some kind of deal ironed out as early as next week. The disclosure comes just weeks after Gritstone tapped the investment bank Raymond James to be its financial adviser as the biotech evaluated potential value-maximizing strategies. Earlier this year, the company laid off a significant portion of its employees and, shortly after, received disappointing results from a key study of its experimental vaccine for colorectal cancer. Jacob BellDenali Therapeuticssaid in a regulatory filingThursday that partner Sanofi has stopped a Phase 2 trial testing one of the biotechs experimental drugs in multiple sclerosis after the therapy missed its main and secondary study goals. The drug, oditrasertib, is part of a broad partnership Denali and Sanofi signed in 2018 to develop treatments for autoimmune and neurological diseases. It previously failed a study in ALS. Delilah AlvaradoA dual regimen of PfizersTalzenna and Xtandi helped people with advanced prostate cancer live longer than those who received Xtandi alone in a clinical trial, regardless of whether they had certain genetic alterations believed to be associated with a stronger benefit, the company said Thursday. The FDA last year approved the Talzenna-Xtandi combinationonly for people with these genetic signatures because of concerns over the safety and effectiveness of so-called PARP inhibitors like Talzenna in a broader population. Its issued similarly narrow clearances to Merck & Co. and AstraZenecas Lynparza and Johnson & Johnsons Akeega. With the new results, though, Pfizer now seeks to expand use of Talzenna. Jonathan GardnerPaul Parker is joining Flagship Pioneering as a managing partner, where hell oversee the biotechnology startup creators fundraising activities and manage its relationships with investors, the firm announced Thursday. Parker, who who previously served in top roles within the mergers and acquisitions groups of Goldman Sachs, Barclays Group and Lehman Brothers, is now Flagships third managing partner along with Doug Cole and Stephen Berenson. His appointment comes three months after Flagship raised $3.6 billion in additional capital and announced more than a dozen promotions and new hires to its leadership team. Gwendolyn WuThe FDA has turned back an experimental hypoglycemia drug from Zealand Pharma for the second time in less than a year. In a statement Tuesday, Zealand said the agency didnt approve the therapy, dasiglucagon, because of the timing related to the re-inspection of a third-party manufacturing facility. An initial examination of the facility uncovered deficiencies unrelated to Zealands drug, but nonetheless led the FDA to reject dasiglucagon in December. The re-inspection took place in August and September, but the manufacturer, which Zealand didnt name, hasnt yet received a positive recommendation. Delilah Alvarado '

Drug ApprovalClinical ResultVaccinePhase 1Executive Change

10 Oct 2024

·www.prnewswire.com

Metastatic Castration-Resistant Prostate Cancer Clinical Trial Pipeline Appears Robust With 90+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight

Metastatic Castration-Resistant Prostate Cancer (mCRPC) refers to prostate cancer that has spread (metastasized) to other parts of the body and continues to progress despite treatments that lower testosterone levels (androgen deprivation therapy or ADT) major pharmaceutical companies are heavily investing in research and development of new treatments, including immunotherapy (e.g., sipuleucel-T) and targeted therapies, which are seen as the next frontier in treating mCRPC. The use of precision medicine to identify genetic profiles in patients has further expanded the potential for targeted treatment. LAS VEGAS , Oct. 10, 2024 /PRNewswire/ -- DelveInsight's ' Metastatic Castration-Resistant Prostate Cancer Pipeline Insight 2024 ' report provides comprehensive global coverage of pipeline mCRPC therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the mCRPC pipeline domain. Key Takeaways from the Metastatic Castration-Resistant Prostate Cancer Pipeline Report DelveInsight's mCRPC pipeline report depicts a robust space with 90+ active players working to develop 100+ pipeline therapies for mCRPC treatment. Key mCRPC companies such as Regeneron Pharmaceuticals, AstraZeneca, Hinova Pharmaceuticals, Zenith Epigenetic, Eli Lilly and Company, Astellas Pharma, Seagen, Pfizer, Progenics Pharmaceutical, Molecular Insight Pharmaceuticals, Bayer, Accutar Biotechnology Inc, Hinova Pharmaceuticals, Forma Therapeutics, Inc., HALDA THERAPEUTICS INC., Tavanta Therapeutics, Lantheus, Pfizer, AB Science, Syntrix Pharmaceuticals, Exelixis, Laekna Therapeutics Shanghai Co. Ltd., Cardiff Oncology, Ipsen, Norroy Bioscience, Astellas Pharma, Novartis, Johnson & Johnson, Tempest Therapeutics, and others are evaluating new mCRPC drugs to improve the treatment landscape. Promising mCRPC pipeline therapies such as REGN 4336, Capivasertib, Deutenzalutamide, ZEN003694, Abemaciclib, Enfortumab vedotin, Talazoparib, I-131-1095, Pelgifatamab corixetan, AC176, HP518, FT-7051, HLD-0915, TAVT-45, PNT2002, Mevrometostat, Masitinib, SX-682, XL092, LAE001, Onvansertib, Tazemetostat, 177Lu-NYM032, PRL-02, 225 Actinium PSMA 617, ARX51, TPST-1120, and others are under different phases of mCRPC clinical trials. In October 2024, Curium announced that it had entered into a strategic partnership with PDRadiopharma Inc, a wholly-owned subsidiary of PeptiDream, for the clinical development, regulatory filing, and commercialization in Japan of 177Lu-PSMA-I&T and 64Cu-PSMA-I&T. The two agents 177Lu-PSMA-I&T and 64Cu-PSMA-I&T target prostate-specific membrane antigen (PSMA) expressed on prostate cancer cells and are being investigated for prostate cancer treatment and diagnostics. In July 2024, the US FDA granted fast-track designation to the prostate-specific membrane antigen (PSMA)–targeted radiopharmaceutical 225Ac-FL-020 for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC). In July 2024, Merck and Orion Corporation announced the mutual exercise of option providing Merck global exclusive rights to Opevesostat, an investigational CYP11A1 inhibitor, for the treatment of Metastatic Castration-Resistant Prostate Cancer. In July 2024, the US FDA granted fast-track designation to the antibody-drug conjugate (ADC) BNT324/DB-1311 to potentially treat patients with unresectable advanced or metastatic castration-resistant prostate cancer (mCRPC) whose disease had progressed on or after standard systemic regimens. In July 2024, FutureChem announced that the FC-705 has received orphan drug designation from the Ministry of Food and Drug Safety (MFDS) for the treatment of prostate cancer. In June 2024, CAR T-Cell Therapy demonstrated promising results for mCRPC according to Phase I trial results. In January 2024, Lava Therapeutics announced that it has signed a clinical trial collaboration and supply agreement with Merck to evaluate its prostate cancer therapy LAVA-1207 as a combination treatment with MSD's Keytruda (pembrolizumab). In July 2024, Blue Earth Therapeutics announced the signing of a clinical research collaboration with University College London (UCL). The collaboration is centered on a Phase I/II trial designed to evaluate the safety, tolerability, radiation dosimetry, and antitumor activity of the 225Ac-rhPSMA-10.1 in men with metastatic castrate-resistant prostate cancer who have previously responded to lutetium 177 (177Lu)-PSMA therapy. Request a sample and discover the recent advances in mCRPC treatment drugs @ Metastatic Castration-Resistant Prostate Cancer Pipeline Report The mCRPC pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage mCRPC drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the mCRPC clinical trial landscape. Metastatic Castration-Resistant Prostate Cancer Overview Metastatic castration-resistant prostate cancer (mCRPC) is an advanced stage of prostate cancer that continues to grow and spread despite hormone therapy aimed at lowering testosterone levels. The term "metastatic" refers to cancer spreading to other parts of the body, such as the bones, lymph nodes, or distant organs, while "castration-resistant" indicates that the cancer no longer responds to treatments that reduce testosterone, a key driver of prostate cancer growth. mCRPC is typically more aggressive and challenging to treat than earlier stages of prostate cancer. The causes of mCRPC stem from genetic and environmental factors. Genetic mutations in the androgen receptor pathway can make cancer cells less dependent on testosterone, allowing them to thrive even under hormone-suppressing treatments. Environmental factors like diet, lifestyle, and exposure to certain chemicals may also contribute to the development and progression of prostate cancer. Symptoms of mCRPC often include pain in bones, fatigue, difficulty urinating, weight loss, and general weakness. As the cancer spreads, it can impair the function of other organs, depending on the site of metastasis. Diagnosis of mCRPC usually involves a combination of tests, including prostate-specific antigen (PSA) blood tests, imaging studies like CT scans, MRIs, or bone scans, and sometimes biopsies to confirm the spread and resistance to treatment. Treatment options for mCRPC are more complex and may include newer hormonal therapies (e.g., abiraterone, enzalutamide), chemotherapy (docetaxel or cabazitaxel), immunotherapy (e.g., sipuleucel-T), or targeted therapies such as PARP inhibitors. Bone-targeting therapies, radiation, and palliative care can also be used to manage symptoms and improve the quality of life. Treatment is typically tailored to the individual based on the extent of the disease and the patient health. Find out more about mCRPC treatment drugs @ Drugs for Metastatic Castration-Resistant Prostate Cancer Treatment A snapshot of the mCRPC Pipeline Drugs mentioned in the report: Learn more about the emerging mCRPC pipeline therapies @ Metastatic Castration-Resistant Prostate Cancer Clinical Trials Metastatic Castration-Resistant Prostate Cancer Therapeutics Assessment The mCRPC pipeline report proffers an integral view of the mCRPC emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration. Scope of the Metastatic Castration-Resistant Prostate Cancer Pipeline Report Coverage: Global Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III Therapeutics Assessment By Route of Administration: Oral, Intravenous, Subcutaneous Therapeutics Assessment By Molecule Type: Small molecule, Cell therapy, Peptides, Polymer, Small molecule, Gene therapy Therapeutics Assessment By Mechanism of Action: Androgen receptor degradation enhancers, Antibody-dependent cell cytotoxicity, Proto-oncogene protein c-akt inhibitors, Androgen receptor antagonists, Bromodomain and extraterminal domain protein inhibitors, Cyclin-dependent kinase 4 inhibitors, Cyclin-dependent kinase 6 inhibitors, Ionizing radiation emitters, PPAR alpha antagonists. Key Metastatic Castration-Resistant Prostate Cancer Companies: Regeneron Pharmaceuticals, AstraZeneca, Hinova Pharmaceuticals, Zenith Epigenetic, Eli Lilly and Company, Astellas Pharma, Seagen, Pfizer, Progenics Pharmaceutical, Molecular Insight Pharmaceuticals, Bayer, Accutar Biotechnology Inc, Hinova Pharmaceuticals, Forma Therapeutics, Inc., HALDA THERAPEUTICS INC., Tavanta Therapeutics, Lantheus, Pfizer, AB Science, Syntrix Pharmaceuticals, Exelixis, Laekna Therapeutics Shanghai Co. Ltd., Cardiff Oncology, Ipsen, Norroy Bioscience, Astellas Pharma, Novartis, Johnson & Johnson, Tempest Therapeutics, and others. Key Metastatic Castration-Resistant Prostate Cancer Pipeline Therapies: REGN 4336, Capivasertib, Deutenzalutamide, ZEN003694, Abemaciclib, Enfortumab vedotin, Talazoparib, I-131-1095, Pelgifatamab corixetan, AC176, HP518, FT-7051, HLD-0915, TAVT-45, PNT2002, Mevrometostat, Masitinib, SX-682, XL092, LAE001, Onvansertib, Tazemetostat, 177Lu-NYM032, PRL-02, 225 Actinium PSMA 617, ARX51, TPST-1120, and others. Dive deep into rich insights for new drugs for mCRPC treatment, visit @ Metastatic Castration-Resistant Prostate Cancer Drugs Table of Contents For further information on the mCRPC Cancer pipeline therapeutics, reach out @ Metastatic Castration-Resistant Prostate Cancer Treatment Drugs Related Reports Metastatic Castration-Resistant Prostate Cancer Market Metastatic Castration-Resistant Prostate Cancer Market Insights, Epidemiology, and Market Forecast – 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key mCRPC companies including AstraZeneca, Merck Sharp & Dohme, Hinova Pharmaceuticals, Pfizer, Astellas Pharma, Modra Pharmaceuticals, AB Science, Eli Lilly and Company, Zr Pharma & GmbH, Bristol-Myers Squibb, Ipsen, Exelixis, Takeda, Janssen Research & Development, Tesaro, Lantheus Holdings, Kintor Pharmaceutical, MacroGenics, Daiichi Sankyo, Madison Vaccines, Novartis, Point Biopharma, Xencor, Essa Pharma, Telix International, Bayer, Arvinas, among others. Metastatic Prostate Cancer Market Metastatic Prostate Cancer Market Insights, Epidemiology, and Market Forecast – 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key metastatic prostate cancer companies including AstraZeneca, Arvinas, Madison Vaccines, Phosplatin Therapeutics, Hinova Pharmaceuticals, Bristol Myers Squibb, Merck, MacroGenics, Daiichi Sankyo, Seagen, Taiho Pharmaceutical, Modra Pharmaceuticals, Xencor, Point Biopharma, Lantheus Holdings, Zenith Epigenetics, Essa Pharma, Telix Pharmaceuticals, Kintor Pharmaceutical, AB Science, Eli Lilly and Company, Exelixis among others. Metastatic Castration-Sensitive Prostate Cancer Market Metastatic Castration-Sensitive Prostate Cancer Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key mCSPC companies including Myovant Sciences, Pfizer, Bayer, Orion, Novartis, AstraZeneca, Pfizer, Janssen, Merck, Eli Lilly, among others. Metastatic Castration-Sensitive Prostate Cancer Pipeline Metastatic Castration-Sensitive Prostate Cancer Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, including clinical and non-clinical stage products, and the key mCSPC companies, including Myovant Sciences, Pfizer, Bayer, Orion, Novartis, AstraZeneca, Pfizer, Janssen, Merck, Eli Lilly, among others. About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . Contact Us Shruti Thakur [email protected] +14699457679 Logo: SOURCE DelveInsight Business Research, LLP WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Fast TrackImmunotherapyPhase 1Clinical Result

100 Deals associated with Talazoparib Tosylate

External Link

KEGG	Wiki	ATC	Drug Bank
-	Talazoparib Tosylate	L01XX60	DB11760

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Breast Cancer	US	Pfizer Inc.	07 Mar 2024
BRCA Mutation Castration-Resistant Prostate Cancer	JP	Pfizer Japan, Inc.	18 Jan 2024
Metastatic castration-resistant prostate cancer	NO	Pfizer Inc.	08 Jan 2024
Metastatic castration-resistant prostate cancer	EU	Pfizer Inc.	08 Jan 2024
Metastatic castration-resistant prostate cancer	LI	Pfizer Inc.	08 Jan 2024
Metastatic castration-resistant prostate cancer	IS	Pfizer Inc.	08 Jan 2024
HRR Gene-mutated Castration-Resistant Prostate Cancer	AU	Pfizer Australia Pty Ltd.	18 Nov 2019
Metastatic breast cancer	CA	PF Consumer Healthcare Canada ULC	06 Sep 2019
Hormone receptor positive breast cancer	IS	Pfizer Europe MA EEIG	20 Jun 2019
Hormone receptor positive breast cancer	NO	Pfizer Europe MA EEIG	20 Jun 2019
Hormone receptor positive breast cancer	EU	Pfizer Europe MA EEIG	20 Jun 2019
Hormone receptor positive breast cancer	LI	Pfizer Europe MA EEIG	20 Jun 2019
Germline BRCA-mutated, HER2-negative metastatic breast cancer	US	Pfizer Inc.	16 Oct 2018

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Castration-Resistant Prostatic Cancer	NDA/BLA	US	Pfizer Inc.	17 Feb 2023
Metastatic castration-resistant prostate cancer	NDA/BLA	US	Pfizer Inc.	16 Feb 2023
Locally advanced breast cancer	Discovery	RU	Pfizer Inc.	14 Oct 2013
Locally advanced breast cancer	Discovery	BE	Pfizer Inc.	14 Oct 2013
Locally advanced breast cancer	Discovery	DE	Pfizer Inc.	14 Oct 2013
Locally advanced breast cancer	Discovery	ES	Pfizer Inc.	14 Oct 2013
Locally advanced breast cancer	Discovery	BR	Pfizer Inc.	14 Oct 2013
Locally advanced breast cancer	Discovery	KR	Pfizer Inc.	14 Oct 2013
Locally advanced breast cancer	Discovery	UA	Pfizer Inc.	14 Oct 2013

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03395197 (TALAPRO-2, Pubmed \| Eur J Cancer)	Phase 3	Metastatic castration-resistant prostate cancer HRR gene alterations	-	Talazoparib 0.5 mg	ugsikkrpiz(dimnbkyrhg) = bwmfcnkedk xybswyuyue (ivmqijbkuz ) View more	Positive	01 Dec 2024
				Enzalutamide 160 mg	ugsikkrpiz(dimnbkyrhg) = esagzvcagc xybswyuyue (ivmqijbkuz ) View more
NCT03395197 (TALAPRO-2, PipelineReview) Manual	Phase 3	Metastatic castration-resistant prostate cancer	-	talazoparib + enzalutamide	(toednujhmi) = Results showed a statistically significant and clinically meaningful improvement in the final OS in all-comers (cohort 1) as well as in those patients with homologous recombination repair (HRR) gene-mutated mCRPC (cohort 2), compared to XTANDI alone. guhjwkwejj (jjafryillh )	Positive	10 Oct 2024
ASTRO	Not Applicable	Extensive stage Small Cell Lung Cancer	-	Talazoparib	wepndrvzei(vtlpdfaarb) = 1 Gr3 TRT or talazoparib+TRT related non-hematologic AE: esophagitis kkqwwlthai (tokpgygvia ) View more	-	01 Oct 2024
				Consolidative Thoracic Radiotherapy (CTRT)
EUCTR2020-001105-24-FR (GETUG-TALASUR, ESMO2024) Manual	Phase 2	Metastatic urothelial carcinoma Maintenance	47	Talazoparib+Avelumab	(xvfvtkawhs) = gflfbskezc sszpwraylc (xgmklcfjui, 3.7 - 9.1) View more	Negative	15 Sep 2024
NCT03395197 (TALAPRO-2, ESMO2024) Manual	Phase 3	Metastatic castration-resistant prostate cancer First line	125	Talazoparib + Enzalutamide	(ekfshqengj) = emksmsylpz ibcwspnelk (yyxbfdsfxs ) View more	Positive	15 Sep 2024
				Placebo + Enzalutamide	(ekfshqengj) = zfgbzwucnv ibcwspnelk (yyxbfdsfxs ) View more
NCT03395197 (TALAPRO-2, ESMO2024)	Phase 3	Metastatic castration-resistant prostate cancer HRR deficient	-	Talazoparib + Enzalutamide	(ipqsoyxrem) = soeniticcv mlkwjskbfy (nkibvmskzk, 5.6 - 16.4)	Positive	15 Sep 2024
				Placebo + Enzalutamide	(ipqsoyxrem) = znyxqfwvra mlkwjskbfy (nkibvmskzk, 1.8 - 11.0)
NCT02912572 (CTgov)	Phase 2	Metastatic endometrial cancer \| Recurrent Endometrial Cancer	106	Avelumab+Talazoparib (MSS Avelumab/Talazoparib Combination Arm)	wsvtmmsetq(tobjcblslf) = sjffozfpjp vsapeikofv (mpmgfknowl, knjxegcvfy - anshioxjxy) View more	-	05 Jul 2024
				Avelumab+Axitinib (MSS Avelumab/Axitinib Combination Arm)	wsvtmmsetq(tobjcblslf) = zhwhmnxkhw vsapeikofv (mpmgfknowl, ywlybhrxmm - jmcmuonhnn) View more
NCT02693535 (Targeted Agent and Profiling Utilization Registry Study, Pubmed)	Phase 2	Advanced Malignant Solid Neoplasm \| Multiple Myeloma	-	Talazoparib	cfedbdotxs(mmrluidiys) = ktjiouenpw largzfvdag (pjjekmosxg, 43 - 100)	Positive	01 Jun 2024
NCT04740190 (TAC-GReD, ASCO2024) Manual	Phase 2	Recurrent Malignant Glioma	33	Talazoparib + carboplatin	(isomympnnc) = ogeidwqktx jxyssfmcqz (dvscjneziy, 16.2 - 51.9) View more	Positive	24 May 2024
NCT04337970 (ASCO2024)	Phase 1/2	Locally Advanced Clear Cell Renal Cell Carcinoma HIF proteins	23	Talazoparib 0.5 mg	(crgagntmrc) = xiwmnzieul quagapksdw (omimdmdqsv, 0 - 30) View more	Negative	24 May 2024

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