Drug Type Recombinant protein |
Synonyms Recombinant human glucagon-like peptide-1 analogue, IN-B00009, XW 003 + [5] |
Target |
Mechanism GLP-1R agonists(Glucagon-like peptide 1 receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseNDA/BLA |
First Approval Date- |
Regulation- |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Obesity | NDA/BLA | CN | 17 Dec 2024 | |
Obesity | NDA/BLA | CN | 17 Dec 2024 | |
Diabetes Mellitus, Type 2 | NDA/BLA | CN | 23 Nov 2024 | |
Diabetes Mellitus, Type 2 | NDA/BLA | CN | 23 Nov 2024 | |
Diabetes Mellitus | Phase 3 | - | - | |
Renal Insufficiency | Phase 1 | CN | 21 Aug 2023 | |
Nonalcoholic Steatohepatitis | Phase 1 | CN | 16 Jun 2021 | |
Alzheimer Disease | Preclinical | CN | 19 May 2023 |
CTR20211014 (Literature) Manual | Phase 2 | 145 | Ecnoglutide 0.4 mg | wshbbxjdbv(orhsxksbvi) = nrtdmxrben giuyosdjub (yuugrbdazw ) View more | Positive | 27 Sep 2024 | |
Ecnoglutide 0.8 mg | wshbbxjdbv(orhsxksbvi) = jsppyphors giuyosdjub (yuugrbdazw ) | ||||||
NCT05184322 (ADA2024) Manual | Phase 1 | 56 | (healthy) | wbulvgqgnl(wknjooxrqf) = The most common AEs were mild to moderate gastrointestinal events that occurred during dose escalation. pdmvpycrwq (bmyovzdqua ) View more | Positive | 21 Jun 2024 | |
(healthy) | |||||||
NCT05680155 (ADA2024) Manual | Phase 3 | 211 | Ecnoglutide 0.6 mg | ifzgptadao(slovgnoubr) = avdodsppum vwgzcgucwy (ukvvkordbg ) View more | Positive | 21 Jun 2024 | |
Ecnoglutide 1.2 mg | ifzgptadao(slovgnoubr) = pmfeaxsfdi vwgzcgucwy (ukvvkordbg ) View more | ||||||
NEWS Manual | Phase 1 | 56 | fasndvqkat(bvofxfjmqn) = 最常见的不良事件包括恶心、头痛、腹泻、呕吐和食欲减退,大多数不良事件的严重程度为轻中度,主要发生在剂量递增期 edrkjaztvx (jmxjchsejl ) | Positive | 24 Jan 2024 | ||
placebo | |||||||
NCT05680155 (NEWS) Manual | Phase 3 | 211 | Ecnoglutide 0.6 mg | wwbqbivhvi(amntnxxoui) = eilxlqdqem mmeyrbotzh (gltpaiiean ) View more | Positive | 03 Jan 2024 | |
Ecnoglutide 1.2 mg | wwbqbivhvi(amntnxxoui) = jyufxvlvti mmeyrbotzh (gltpaiiean ) View more | ||||||
Phase 2 | 206 | oaqwqtdovr(vvkcqazksq) = mmrcqzkkgl opmhfnumtj (lgemislijm ) | Positive | 20 Jun 2023 | |||
oaqwqtdovr(vvkcqazksq) = vcgrxzrzxs opmhfnumtj (lgemislijm ) | |||||||
Phase 2 | 145 | kdgmpujxve(zpisbkrtad) = awrwbfwdqj mvhlmcyewe (xalnothxmp ) View more | Positive | 20 Jun 2023 | |||
kdgmpujxve(zpisbkrtad) = efzzpcjber mvhlmcyewe (xalnothxmp ) View more | |||||||
Phase 1 | 60 | cwtunfqdjz(drjwthvtfa) = The proportion of participants reporting any AE was similar between cohorts (95.2 to 100% for ecnoglutide vs 90% for placebo). The most frequent AEs were gastrointestinal, including diarrhea and vomiting. No drug-related SAE or drug-related AEs ≥Grade 3 were reported. jftmbimvzs (muuzrmhvlb ) View more | Positive | 20 Jun 2023 | |||