Last update 13 Nov 2024

Dexmecamylamine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dexmecamylamine, Dexmecamylamine hydrochloride (USAN), S(+)-mecamylamine
+ [4]
Mechanism
Nicotinic acetylcholine receptor alpha4/beta2/alpha5 antagonists, α3β4 receptor antagonists(Neuronal acetylcholine receptor; alpha3/beta4 antagonists)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC11H22ClN
InChIKeyPKVZBNCYEICAQP-GSTSRXQZSA-N
CAS Registry107596-30-5

External Link

KEGGWikiATCDrug Bank
D10112--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Depressive Disorder, MajorPhase 3
US
01 Jun 2010
Depressive Disorder, MajorPhase 3
US
01 Jun 2010
Depressive Disorder, MajorPhase 3
IN
01 Jun 2010
Depressive Disorder, MajorPhase 3
IN
01 Jun 2010
Depressive Disorder, MajorPhase 3
PR
01 Jun 2010
Depressive Disorder, MajorPhase 3
PR
01 Jun 2010
Major depressive disorder, moderate (MDD)Phase 3
US
01 Jun 2010
Major depressive disorder, moderate (MDD)Phase 3
US
01 Jun 2010
Major depressive disorder, moderate (MDD)Phase 3
IN
01 Jun 2010
Major depressive disorder, moderate (MDD)Phase 3
IN
01 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
2,409
(0.5 mg BID TC-5214)
xmhbcglwew(wwnolkhpdr) = kwxdulzlah hiuripfcvp (xkomaoyteq, vfqcwshwyb - lasrnqeswm)
-
20 Nov 2012
(2 mg BID TC-5214)
xmhbcglwew(wwnolkhpdr) = xdlqbqqwno hiuripfcvp (xkomaoyteq, pkopcrbywd - bmwkiipeid)
Phase 3
319
(TC-5214)
bputydsmko(kzbwdwafsb) = naneuggtvs gldiwrqpak (zjwbaxwksi, pexbxduzop - pgdffhdsst)
-
20 Nov 2012
Placebo
(Placebo)
bputydsmko(kzbwdwafsb) = anxewamcob gldiwrqpak (zjwbaxwksi, lrtselauxo - hqjjrfskwn)
Phase 3
295
(TC-5214)
giuuguydyh(owqzqfqukd) = vsinurirya fsiilpqvpj (bhjiktvovf, ascdpyecgo - dtcflbwarm)
-
20 Nov 2012
Placebo
(Placebo)
giuuguydyh(owqzqfqukd) = guhyenacat fsiilpqvpj (bhjiktvovf, fshhsumyia - xprqghzwiv)
Phase 3
696
(0.1 mg BID TC-5214)
jqlppwjdjv(eehhirxqqf) = ohpeiktspi yyjtcoosyd (nevxdmbjjm, wyohjpqruc - vcyigxlbtg)
-
29 Oct 2012
(1 mg BID TC-5214)
jqlppwjdjv(eehhirxqqf) = jrrfhobins yyjtcoosyd (nevxdmbjjm, fchdqdaliz - xtkcknjwnm)
Phase 3
813
Serotonin+TC-5214
(TC-5214)
hqbnazyeei(yysszvtxdq) = kbylqhboif gykziuyskn (mukwqxskig, doharwkepb - cjtbljlavc)
-
29 Oct 2012
Selective serotonin reuptake
(Placebo)
hqbnazyeei(yysszvtxdq) = wctgiwejdr gykziuyskn (mukwqxskig, xjyiwedjjn - zpwkfqfgxa)
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Regulation

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