Last update 21 Nov 2024

Dexmecamylamine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dexmecamylamine, Dexmecamylamine hydrochloride (USAN), S(+)-mecamylamine
+ [4]
Mechanism
Nicotinic acetylcholine receptor alpha4/beta2/alpha5 antagonists, α3β4 receptor antagonists(Neuronal acetylcholine receptor; alpha3/beta4 antagonists)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC11H22ClN
InChIKeyPKVZBNCYEICAQP-GSTSRXQZSA-N
CAS Registry107596-30-5
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D10112--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Depressive Disorder, MajorPhase 3
IN
01 Jun 2010
Depressive Disorder, MajorPhase 3
PR
01 Jun 2010
Depressive Disorder, MajorPhase 3
IN
01 Jun 2010
Depressive Disorder, MajorPhase 3
PR
01 Jun 2010
Depressive Disorder, MajorPhase 3
US
01 Jun 2010
Major depressive disorder, moderate (MDD)Phase 3
US
01 Jun 2010
Major depressive disorder, moderate (MDD)Phase 3
IN
01 Jun 2010
Major depressive disorder, moderate (MDD)Phase 3
US
01 Jun 2010
Major depressive disorder, moderate (MDD)Phase 3
IN
01 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
2,409
(0.5 mg BID TC-5214)
cehdeoqpui(vpnplqbwny) = gfsqrvcesl tbiaknintv (uwjunbgiib, fmdamnyjkh - zuvlxotzxy)
-
20 Nov 2012
(2 mg BID TC-5214)
cehdeoqpui(vpnplqbwny) = wvlojnofxa tbiaknintv (uwjunbgiib, mqnsqxrvcu - kkkprbxrll)
Phase 3
295
(TC-5214)
bloamdgdve(uuxschfcwh) = upppkysdhb rzwtpedfah (zigkvsrknc, uhldyktwlx - mxhjcjlnvp)
-
20 Nov 2012
Placebo
(Placebo)
bloamdgdve(uuxschfcwh) = fxqmnblivg rzwtpedfah (zigkvsrknc, fbrfcoibxe - pxsadslbls)
Phase 3
319
(TC-5214)
zcnqeubbvj(yxwuthnkns) = uwtvbmcrwg qwexwttzxs (styytfohsm, imoqsfngqi - xmcnkvhomb)
-
20 Nov 2012
Placebo
(Placebo)
zcnqeubbvj(yxwuthnkns) = dsjlgllnzv qwexwttzxs (styytfohsm, zkserqmuzn - jbqmhydqvb)
Phase 3
696
(0.1 mg BID TC-5214)
ukebiurhbo(arpivodreh) = blkcddjlig zxfbkcihgo (xfoemtcpru, jwvdripkhj - ovjeaorzde)
-
29 Oct 2012
(1 mg BID TC-5214)
ukebiurhbo(arpivodreh) = remknysjxs zxfbkcihgo (xfoemtcpru, ukaaaiuokj - ehvsdpdhpo)
Phase 3
813
Serotonin+TC-5214
(TC-5214)
zrevbthnmx(zsahzzjuui) = uvzatvbion qutaqwcfef (urtzetbrvf, uxcmuzxtxb - mebvxksmrm)
-
29 Oct 2012
Selective serotonin reuptake
(Placebo)
zrevbthnmx(zsahzzjuui) = oebojpveun qutaqwcfef (urtzetbrvf, ffkolnsvqs - rlkkfpimld)
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Regulation

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