Drug Type Small molecule drug |
Synonyms Dexmecamylamine, Dexmecamylamine hydrochloride (USAN), S(+)-mecamylamine + [4] |
Mechanism Nicotinic acetylcholine receptor alpha4/beta2/alpha5 antagonists, α3β4 receptor antagonists(Neuronal acetylcholine receptor; alpha3/beta4 antagonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC11H22ClN |
InChIKeyPKVZBNCYEICAQP-GSTSRXQZSA-N |
CAS Registry107596-30-5 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Depressive Disorder, Major | Phase 3 | US | 01 Jun 2010 | |
Depressive Disorder, Major | Phase 3 | US | 01 Jun 2010 | |
Depressive Disorder, Major | Phase 3 | IN | 01 Jun 2010 | |
Depressive Disorder, Major | Phase 3 | IN | 01 Jun 2010 | |
Depressive Disorder, Major | Phase 3 | PR | 01 Jun 2010 | |
Depressive Disorder, Major | Phase 3 | PR | 01 Jun 2010 | |
Major depressive disorder, moderate (MDD) | Phase 3 | US | 01 Jun 2010 | |
Major depressive disorder, moderate (MDD) | Phase 3 | US | 01 Jun 2010 | |
Major depressive disorder, moderate (MDD) | Phase 3 | IN | 01 Jun 2010 | |
Major depressive disorder, moderate (MDD) | Phase 3 | IN | 01 Jun 2010 |
Phase 3 | 2,409 | (0.5 mg BID TC-5214) | xmhbcglwew(wwnolkhpdr) = kwxdulzlah hiuripfcvp (xkomaoyteq, vfqcwshwyb - lasrnqeswm) View more | - | 20 Nov 2012 | ||
(2 mg BID TC-5214) | xmhbcglwew(wwnolkhpdr) = xdlqbqqwno hiuripfcvp (xkomaoyteq, pkopcrbywd - bmwkiipeid) View more | ||||||
Phase 3 | 319 | (TC-5214) | bputydsmko(kzbwdwafsb) = naneuggtvs gldiwrqpak (zjwbaxwksi, pexbxduzop - pgdffhdsst) View more | - | 20 Nov 2012 | ||
Placebo (Placebo) | bputydsmko(kzbwdwafsb) = anxewamcob gldiwrqpak (zjwbaxwksi, lrtselauxo - hqjjrfskwn) View more | ||||||
Phase 3 | 295 | (TC-5214) | giuuguydyh(owqzqfqukd) = vsinurirya fsiilpqvpj (bhjiktvovf, ascdpyecgo - dtcflbwarm) View more | - | 20 Nov 2012 | ||
Placebo (Placebo) | giuuguydyh(owqzqfqukd) = guhyenacat fsiilpqvpj (bhjiktvovf, fshhsumyia - xprqghzwiv) View more | ||||||
Phase 3 | 696 | (0.1 mg BID TC-5214) | jqlppwjdjv(eehhirxqqf) = ohpeiktspi yyjtcoosyd (nevxdmbjjm, wyohjpqruc - vcyigxlbtg) View more | - | 29 Oct 2012 | ||
(1 mg BID TC-5214) | jqlppwjdjv(eehhirxqqf) = jrrfhobins yyjtcoosyd (nevxdmbjjm, fchdqdaliz - xtkcknjwnm) View more | ||||||
Phase 3 | 813 | Serotonin+TC-5214 (TC-5214) | hqbnazyeei(yysszvtxdq) = kbylqhboif gykziuyskn (mukwqxskig, doharwkepb - cjtbljlavc) View more | - | 29 Oct 2012 | ||
Selective serotonin reuptake (Placebo) | hqbnazyeei(yysszvtxdq) = wctgiwejdr gykziuyskn (mukwqxskig, xjyiwedjjn - zpwkfqfgxa) View more |