Drug Type Small molecule drug |
Synonyms Dexmecamylamine, Dexmecamylamine hydrochloride (USAN), S(+)-mecamylamine + [4] |
Mechanism Nicotinic acetylcholine receptor alpha4/beta2/alpha5 antagonists, α3β4 receptor antagonists(Neuronal acetylcholine receptor; alpha3/beta4 antagonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC11H22ClN |
InChIKeyPKVZBNCYEICAQP-GSTSRXQZSA-N |
CAS Registry107596-30-5 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Depressive Disorder, Major | Phase 3 | IN | 01 Jun 2010 | |
Depressive Disorder, Major | Phase 3 | PR | 01 Jun 2010 | |
Depressive Disorder, Major | Phase 3 | IN | 01 Jun 2010 | |
Depressive Disorder, Major | Phase 3 | PR | 01 Jun 2010 | |
Depressive Disorder, Major | Phase 3 | US | 01 Jun 2010 | |
Major depressive disorder, moderate (MDD) | Phase 3 | US | 01 Jun 2010 | |
Major depressive disorder, moderate (MDD) | Phase 3 | IN | 01 Jun 2010 | |
Major depressive disorder, moderate (MDD) | Phase 3 | US | 01 Jun 2010 | |
Major depressive disorder, moderate (MDD) | Phase 3 | IN | 01 Jun 2010 |
Phase 3 | 2,409 | (0.5 mg BID TC-5214) | cehdeoqpui(vpnplqbwny) = gfsqrvcesl tbiaknintv (uwjunbgiib, fmdamnyjkh - zuvlxotzxy) View more | - | 20 Nov 2012 | ||
(2 mg BID TC-5214) | cehdeoqpui(vpnplqbwny) = wvlojnofxa tbiaknintv (uwjunbgiib, mqnsqxrvcu - kkkprbxrll) View more | ||||||
Phase 3 | 295 | (TC-5214) | bloamdgdve(uuxschfcwh) = upppkysdhb rzwtpedfah (zigkvsrknc, uhldyktwlx - mxhjcjlnvp) View more | - | 20 Nov 2012 | ||
Placebo (Placebo) | bloamdgdve(uuxschfcwh) = fxqmnblivg rzwtpedfah (zigkvsrknc, fbrfcoibxe - pxsadslbls) View more | ||||||
Phase 3 | 319 | (TC-5214) | zcnqeubbvj(yxwuthnkns) = uwtvbmcrwg qwexwttzxs (styytfohsm, imoqsfngqi - xmcnkvhomb) View more | - | 20 Nov 2012 | ||
Placebo (Placebo) | zcnqeubbvj(yxwuthnkns) = dsjlgllnzv qwexwttzxs (styytfohsm, zkserqmuzn - jbqmhydqvb) View more | ||||||
Phase 3 | 696 | (0.1 mg BID TC-5214) | ukebiurhbo(arpivodreh) = blkcddjlig zxfbkcihgo (xfoemtcpru, jwvdripkhj - ovjeaorzde) View more | - | 29 Oct 2012 | ||
(1 mg BID TC-5214) | ukebiurhbo(arpivodreh) = remknysjxs zxfbkcihgo (xfoemtcpru, ukaaaiuokj - ehvsdpdhpo) View more | ||||||
Phase 3 | 813 | Serotonin+TC-5214 (TC-5214) | zrevbthnmx(zsahzzjuui) = uvzatvbion qutaqwcfef (urtzetbrvf, uxcmuzxtxb - mebvxksmrm) View more | - | 29 Oct 2012 | ||
Selective serotonin reuptake (Placebo) | zrevbthnmx(zsahzzjuui) = oebojpveun qutaqwcfef (urtzetbrvf, ffkolnsvqs - rlkkfpimld) View more |