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Late breaking poster presentation highlights Revian's patented combination of wavelengths has been shown to reduce Dihydrotestosterone production by 74% MORRISVILLE, N.C., May 14, 2024 /PRNewswire/ -- REVIAN Inc., an aesthetic medical technology company using precise wavelengths of LED light to rejuvenate hair and skin, announced an upcoming presentation at the 2024 Society for Investigative Dermatology Annual Meeting being held in Dallas on May 15-18, 2024. Dr. Jacob Kocher will deliver a poster presentation of data illustrating that Revian's patented combination of wavelengths reduces Dihydrotestosterone (DHT) production by 74%, a 95% improvement over industry standard finasteride, which reduced DHT production by 38%, at 24 hours post treatment, in the same in vitro experiment. DHT plays an important causative role in pattern hair loss (androgenic alopecia or pattern baldness). Presentation Details: Poster Title: Inhibition of dihydrotestosterone (DHT) formation via dual wavelength orange-red light production of nitric oxide Category: Translational Studies and Early Preclinical to Clinical Session: Poster only Session Date and Time: May 17th, 4:00-6:00 PM Location: Trinity Exhibit Hall, Hilton Anatole, Dallas "These tests prove Revian's proprietary combination of 620 nm and 660 nm wavelengths block DHT production at a greater rate than the industry standard Finasteride. This is a major breakthrough for hair loss research." stated John Oakley, Chief Executive Officer of Revian. "Having an alternative to a systemic drug with serious side effects is a massive improvement to the available treatment options for anyone seeking a more healthy solution to stopping hair loss." More information on the 2024 Society for Investigative Dermatology Annual Meeting can be found here. About the Revian Red Hair Growth System The REVIAN RED System is an FDA cleared, lightweight wireless cap controlled by a mobile App that functions to provide a hair loss treatment for men and women using precision LED light. The device's patented dual wavelength LED technology provides broader scalp coverage and better skin penetration, producing the best clinical trial performance of any hair rejuvenation treatment available on the market. REVIAN RED uses a patented combination of two wavelengths of light to stimulate the production and release of nitric oxide, which is proven to increase local blood flow, reduce inflammation, and inhibit DHT production. This provides the right environment for new hair growth. REVIAN RED's cleared indication for use is the treatment of androgenetic alopecia, to promote hair growth in males who have Norwood-Hamilton classifications of IIa-V patterns of hair loss and to treat androgenetic alopecia and to promote hair growth in females who have Ludwig-Savin Scale I-1 to II-4, II1, II2 or frontal patterns of hair loss; both with Fitzpatrick Skin Types I-IV. About Revian, Inc. Revian, an operating subsidiary of KNOW Bio, LLC, is an aesthetic medical technology innovator dedicated to stimulating the body's natural processes to rejuvenate hair and skin with light. The company creates products that deliver precise wavelengths of light and allow people to experience its regenerative potential in the convenience of their own homes. Revian is committed to partnering with health-care providers, and other caring professionals, to deliver meaningful results, backed by scientific data. For more information visit . Contact: John Oakley REVIAN, Inc. [email protected] 919-939-7715 SOURCE REVIAN, Inc.

Researchers investigate the intricacies of various cellular processes and pathologies and identify compounds with untapped therapeutic potential XI'AN, China, March 29, 2024 /PRNewswire/ -- Understanding the underlying mechanisms of normal and pathological cellular processes is essential for developing new drugs. Fortunately, modern techniques and experimental methods have greatly accelerated progress. The latest issue of JPA features three articles in which candidate compounds for treating complex disorders were successfully identified, alongside their detailed mechanisms of action. Continue Reading Recent JPA studies identify, through detailed analyses of molecular mechanisms and cellular processes, three potential drug candidates for three different pathologies. The first study investigated the use of metformin (Met), a drug used to manage type II diabetes, for treating benign prostate hyperplasia (BPH). The article was published in Volume 14, Issue 1 of the journal in January 2024. The researchers first sought to shed light on how and which dysregulated sex steroid hormone-related pathways shape the pathological characteristics of BPH, and whether Met can restore these pathways. Through retrospective analysis of data from BPH patients and clinical assessment of serum and tissue samples, the researchers identified dihydrotestosterone (DHT) as a major contributor to BPH among dysregulated sex hormones. DHT promotes prostate cell proliferation by upregulating androgen receptors and forming YAP1-TEAD4 heterodimers. In vivo experiments showed that Met treatment restored sex hormone homeostasis and inhibited DHT-induced cell proliferation. "Our study provided strong evidence that Met might be a promising clinical therapeutic approach for the treatment of BPH," remark corresponding authors Prof. Qian Lu and Prof. Xiaoxing Yin. In the second study, scientists explored the role of epimedin B (EB), the main flavonoid in the Chinese herb Epimedium brevicornum Maxim., in melanogenesis. They expanded on previous findings showing EB's ability to induce melanogenesis and activate tyrosinase family of proteins (TYRs). Through comprehensive in vitro and in vivo experiments on human and animal cells, they uncovered how EB modulated TYRs, increased melanosome numbers, promoted maturation, and aided depigmentation and repigmentation. "Our data reveals that EB can stimulate the pigmentation function of TYRs, which might provide a novel rational strategy for hypopigmentation treatment in the pharmaceutical and cosmetic industries," comments corresponding authors Dr. Yiming Li and Prof. Huali Wu. Finally, in the third study, researchers investigated ferroptosis, a type of programmed cell death, and its role in nerve regeneration after peripheral nerve injury (PNI). They found that oxidative stress at the injury site not only triggered both apoptosis and ferroptosis in nearby neurons by increasing intracellular iron via the degradation of ferroportin by UBA52. Using the Drug Signatures Database, they identified hydralazine (HYD), a potent arterial vasodilator, as a potential UBA52 disruptor. Early HYD administration after PNI in vivo expedited axon regeneration and motor function recovery, partly by suppressing ferroptosis. "The potential clinical implementation of HYD may lead to a reduction in the prevalence of individuals with mild symptoms of nerve damage, consequently mitigating the societal burden," conclude corresponding authors Dr. Bing Xia, Prof. Zhuojing Luo, and Dr. Jinghui Huang. Further studies will hopefully clarify the intricate connections among cellular processes, diseases, and potential drugs, paving the way for precise and efficient therapies. Reference Titles of original papers Metformin: A promising clinSical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression, activity, and stability Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52 Journal: Journal of Pharmaceutical Analysis DOI 1. 2. 3. Media contact Mengjie Wang [email protected] +86-(0)29-88960092 SOURCE Journal of Pharmaceutical Analysis (JPA)