MI-078

Main objectives: To investigate the total radioactivity in urine and feces of healthy adult male participants after a single oral administration of [14C]-MI078, to obtain the human radioactivity recovery rate and major excretion pathway; to analyze the total radioactivity in whole blood and plasma of participants after a single oral administration of [14C]-MI078, to obtain the pharmacokinetic parameters of total radioactivity in plasma and whole blood (if applicable), and to investigate the distribution of total radioactivity in whole blood and plasma; to obtain the radiometabolite profiles of human plasma, urine, and feces after oral administration of [14C]-MI078, to identify major metabolites, and to determine metabolic and elimination pathways. Secondary objective: To quantitatively analyze the concentrations of MI078, metabolite MI001, and other metabolites (if applicable) in plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and to evaluate the pharmacokinetic parameters of MI078, metabolite MI001, and other metabolites (if applicable) in plasma; and to evaluate the safety and tolerability of a single oral dose of [14C]-MI078 in healthy adult male study participants.