Delving into the Latest Updates on L-Arginine hydrochloride/L-Lysine hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Arginine/Lysine, L-Arginine Hydrochloride / L-Lysine Hydrochloride, L-Lysine HCl/L-Arginine HCl

+ [5]

Target-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication

Radiation Injuries

Inactive Indication-

Originator Organization

Advanced Accelerator Applications SA

Active Organization

Novartis Pharma KK

FUJIFILM Toyama Chemical Co., Ltd.

Advanced Accelerator Applications SA

+ [1]

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

EU (25 Jul 2019),

Radiation Injuries

RegulationOrphan Drug (KR)

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Structure

Molecular FormulaC6H15ClN4O2

InChIKeyKWTQSFXGGICVPE-WCCKRBBISA-N

CAS Registry1119-34-2

View All Structures (2)

The purpose of this study is to evaluate the change in the expression of treatment targets on the surface of tumor cells (Prostate Specific Membrane Antigen (PSMA), Somatostatin Receptor 2 (SSTR2), and Gastrin Releasing Peptide Receptor (GRPR) between the start and after the completion of radioligand therapy (RLT). Study will use radioligand imaging (RLI) to determine predominantly expressed target on the surface of tumor cells. Based on predominant expression of target, corresponding RLT targeting PSMA, SSTR2, or GRPR RLT will be given for up to 6 cycles every 6 weeks as intravenous (i.v.) injection in participants with metastatic neuroendocrine prostate cancer (mNEPC).

Start Date29 Jul 2024

Sponsor / Collaborator

Novartis Pharmaceuticals Corp.

IRCT20230603058376N1 / RecruitingPhase 1IIT

Evaluation of the effect of arginine administration on height growth of Children in lower limit range

Start Date11 Oct 2023

Sponsor / Collaborator

Ardabil University of Medical Sciences

IRCT20230728058947N1 / RecruitingPhase 2IIT

Investigating the amount of salivary pH changes following the use of arginine mouthwash: a randomized clinical trial

Start Date01 Aug 2023

Sponsor / Collaborator

Shahid Beheshti University of Medical Sciences

100 Clinical Results associated with L-Arginine hydrochloride/L-Lysine hydrochloride

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100 Translational Medicine associated with L-Arginine hydrochloride/L-Lysine hydrochloride

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100 Patents (Medical) associated with L-Arginine hydrochloride/L-Lysine hydrochloride

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30

Literatures (Medical) associated with L-Arginine hydrochloride/L-Lysine hydrochloride

01 Nov 2023·Amino Acids

Shuttle between arginine and lysine: influence on cancer immunonutrition

Review

Author: Prasad, Shashanka K ; Sindhu, R ; Supreeth, M ; Thanmaya, M

Amino acids which are essential nutrients for all cell types' survival are also recognised to serve as opportunistic/alternative fuels in cancers auxotrophic for specific amino acids. Accordingly, restriction of amino acids has been utilised as a therapeutic strategy in these cancers. Contrastingly, amino acid deficiencies in cancer are found to greatly impair immune functions, increasing mortality and morbidity rates. Dietary and supplemental amino acids in such conditions have revealed their importance as 'immunonutrients' by modulating cellular homeostasis processes and halting malignant progression. L-arginine specifically has attracted interest as an immunonutrient by acting as a nodal regulator of immune responses linked to carcinogenesis processes through its versatile signalling molecule, nitric oxide (NO). The quantum of NO generated directly influences the cytotoxic and cytostatic processes of cell cycle arrest, apoptosis, and senescence. However, L-lysine, a CAT transporter competitor for arginine effectively limits arginine input at high L-lysine concentrations by limiting arginine-mediated effects. The phenomenon of arginine-lysine antagonism can, therefore, be hypothesised to influence the immunonutritional effects exerted by arginine. The review highlights aspects of lysine's interference with arginine-mediated NO generation and its consequences on immunonutritional and anti-cancer effects, and discusses possible alternatives to manage the condition. However, further research that considers monitoring lysine levels in arginine immunonutritional therapy is essential to conclude the hypothesis.

01 Mar 2022·Current Radiopharmaceuticals

Comparison of Two Types of Amino Acid Solutions on 177Lu-Dotatate Pharmacokinetics and Pharmacodynamics in Patients with Metastatic Gastroenteropancreatic Neuroendocrine Tumors

Article

Author: Brillouet, Séverine ; Chatelut, Etienne ; Courbon, Frédéric ; Dierickx, Lawrence ; Lambert, Marie

Background:177Lu-Dotatate is used in the treatment of somatostatin-receptor-positive inoperable progressive gastroenteropancreatic neuroendocrine tumors. A co-infusion of amino acids (AAs) is administered to prevent renal toxicity.Objective:This study aimed to quantify the impact of two types of AA cocktails on the pharmacokinetics and toxicity of 177Lu-Dotatate.Method:Four injections of 7400 MBq 177Lu-Dotatate were given per patient with administration of either Primene® 10% (containing a cocktail of 20 AAs with 22g of Lysine and 16.8 g of Arginine) or Lysakare® (containing 25 g of Lysine and 25 g of Arginine). Nine blood samples were collected at each cycle. Radioactivity-time data were analyzed according to a population-based model using NONMEM (version 7.4.1). Renal and hematological toxicity was evaluated after each cycle.Result:1,678 177Lu-Dotatate plasma concentrations versus time were analyzed from 83 consecutive patients with Primene® (n= 45 pts) or Lysakare® (n= 36 pts). Population pharmacokinetic analysis showed that Primene® significantly increased the elimination rate constant of 177Lu-Dotatate as opposed to Lysakare®. Primene® also significantly lowered Lutathera® plasma exposure (AUC) by 34%, whereas Lysakare® increased AUC by 7%. There was no renal toxicity in either case. Lymphopenia significantly correlated with AUC (p=0.021) with a trend towards higher toxicity with Lysakare®.Conclusions::Unlike Primene®, Lysakare® does not increase 177Lu-Dotatate elimination. This difference is associated with a significant impact on AUC. The latter parameter has a high interpatient variability but a low intrapatient variability, which could have important clinical implications for treatment tailoring.

10 Mar 2016·Journal of Medicinal ChemistryQ1 · MEDICINE

A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis

Q1 · MEDICINE

Article

Author: Lai, Ren ; Liu, Weihui ; Jin, Lin ; Luan, Ning ; Yan, Xiuwen ; Chen, Yan ; Zhang, Zhiye ; Lu, Qiumin ; Rong, Mingqiang ; Bai, Xuewei ; Yao, Huimin

New therapeutic agents for Candida albicans vaginitis are urgently awaiting to be developed because of the increasing antibiotic resistance of C. albicans. Antimicrobial peptides (AMPs) are one of the most promising choices for next-generation antibiotics. In this study, novel peptides were designed based on snake venom antimicrobial peptide cathelicidin-BF to promote anti-C. albicans activity and decrease side-effects. The designing strategies include substitutions of charged or hydrophobic amino acid residues for noncharged polar residues to promote antimicrobial activity and insertion of a hydrophobic residue in the hydrophilic side of the helix structure to reduce hemolysis. A designed tryptophan and lysine/arginine-rich cationic peptide 4 (ZY13) (VKRWKKWRWKWKKWV-NH2) exhibited excellent antimicrobial activity against either common strain or clinical isolates of antibiotic-resistant C. albicans with little hemolysis. Peptide 4 showed significant therapeutic effects on vaginitis in mice induced by the infection of clinical antibiotic-resistant C. albicans. The approaches herein might be useful for designing of AMPs.

100 Deals associated with L-Arginine hydrochloride/L-Lysine hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Radiation Injuries	NO	Advanced Accelerator Applications SA	25 Jul 2019
Radiation Injuries	IS	Advanced Accelerator Applications SA	25 Jul 2019
Radiation Injuries	LI	Advanced Accelerator Applications SA	25 Jul 2019
Radiation Injuries	EU	Advanced Accelerator Applications SA	25 Jul 2019

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


Pubmed \| J Clin Endocrinol Metab	Not Applicable	Diabetes Insipidus, Neurogenic	-	Arginine (Patients with central diabetes insipidus)	(nigvgkvvhe) = iuipolecyv wotcjkngcg (lkfmumuivr ) View more	-	01 Jul 2020
				Arginine (Patients with primary polydipsia)	(nigvgkvvhe) = kmbjdvfkyr wotcjkngcg (lkfmumuivr ) View more
Pubmed \| J Clin Endocrinol Metab	Not Applicable	Dwarfism, Pituitary	-	Macimorelin	dglgihfeed(ikyhldcnia) = hjgcpcwyrw afucjgzlpf (kykrprswzc )	-	01 Jun 2013
				Arginine+GHRH	dglgihfeed(ikyhldcnia) = xzhjbkardm afucjgzlpf (kykrprswzc )