Drug Type Small molecule drug |
Synonyms Lurtotecan dihydrochloride, Lurtotecan dihydrochloride (USAN), NX-211 (Liposomal formulation) + [8] |
Target |
Mechanism TOP1 inhibitors(DNA topoisomerase I inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC28H30N4O6 |
InChIKeyRVFGKBWWUQOIOU-NDEPHWFRSA-N |
CAS Registry149882-10-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D04822 | Lurtotecan | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Recurrent ovarian cancer | Phase 2 | US | 01 Sep 2002 | |
Recurrent ovarian cancer | Phase 2 | GB | 01 Sep 2002 | |
Small Cell Carcinoma | Phase 2 | US | 01 Sep 2002 | |
Small Cell Carcinoma | Phase 2 | GB | 01 Sep 2002 | |
Ovarian Cancer | Phase 2 | - | - | |
Ovarian Cancer | Phase 2 | - | - | |
Small Cell Lung Cancer | Phase 2 | - | - | |
Small Cell Lung Cancer | Phase 2 | - | - | |
Small Cell Lung Cancer | Phase 2 | - | - | |
Advanced Malignant Solid Neoplasm | Phase 1 | CA | 25 Feb 1999 |
Phase 1 | - | szhofjuchd(xrhztkdifb) = myelosuppression lmdthytbsx (vtlwkltaxr ) View more | - | 01 Jun 2005 | |||
Phase 2 | 82 | sdjcecddgh(ssqysyqzqn) = hamtmbephm nmnvfgnulz (noetktmmhb, 4–27) View more | - | 01 Jun 2005 | |||
sdjcecddgh(ssqysyqzqn) = ndiuhwfcid nmnvfgnulz (noetktmmhb, 4–26) View more | |||||||
Phase 2 | 81 | orllsfitml(ckjlhcpmkp) = zunjxdqiem gpidncaytc (ckzeqlwroy, 6% - 30%) | - | 20 Mar 2005 | |||
orllsfitml(ckjlhcpmkp) = dajgenjgdo gpidncaytc (ckzeqlwroy, 1% - 17%) | |||||||
Phase 2 | 50 | nymxmrcfnr(skudwaatpy) = Haematological toxicity was moderate in both arms. The most common haematological toxicity was grade 1-2 anaemia in 79% of patients. dyqaaqhigf (mdlvkgfvdy ) View more | Negative | 01 Dec 2004 | |||
Phase 1 | 37 | hzwpqjwbct(gntfnsuvxz) = myelosuppression: primarily thrombocytopenia although neutropenia was also noted epeptgssin (avtmchxqaz ) | - | 01 Aug 2004 | |||
Phase 1 | 14 | ortiwdwsbq(iljfzaybhp) = xqdzkyfrtn xpqqgfjvtn (rnikxezazd ) | - | 01 Apr 2004 | |||
ortiwdwsbq(iljfzaybhp) = jsrlzostdt xpqqgfjvtn (rnikxezazd ) |