A Phase 1a/1b Dose Escalation and Expansion Study of SC-003 as a Single-Agent and in Combination With ABBV-181 in Subjects With Platinum-Resistant/ Refractory Ovarian Cancer

This is a Phase 1a/1b study of SC-003 as a single agent and in combination with ABBV-181 in patients with platinum-resistant/refractory ovarian cancer. SC-003 is an antibody-drug conjugate (ADC) comprised of a monoclonal antibody linked to a potent chemotherapy. ABBV-181 is a humanized, recombinant, mAb that binds to cell surface expressed programmed cell death 1 (PD-1).

Start Date01 Aug 2015

Sponsor / Collaborator

Stemcentrx, Inc.

100 Clinical Results associated with Tamrintamab pamozirine

100 Translational Medicine associated with Tamrintamab pamozirine

100 Patents (Medical) associated with Tamrintamab pamozirine

Literatures (Medical) associated with Tamrintamab pamozirine

01 Nov 2023·Science of The Total Environment

Production of chemicals and utilities in-house improves the environmental sustainability of phytoplankton-based biorefinery

Article

Author: Hosseinzadeh-Bandbafha, Homa ; Karimi, Keikhosro ; Liu, Dan ; Peng, Wanxi ; Aghbashlo, Mortaza ; Chisti, Yusuf ; Madadi, Meysam ; Tabatabaei, Meisam ; Kiehbadroudinezhad, Mohammadali

Life cycle assessment was used to evaluate the environmental impacts of phytoplanktonic biofuels as possible sustainable alternatives to fossil fuels. Three scenarios were examined for converting planktonic biomass into higher-value commodities and energy streams using the alga Scenedesmus sp. and the cyanobacterium Arthrospira sp. as the species of interest. The first scenario (Sc-1) involved the production of biodiesel and glycerol from the planktonic biomass. In the second scenario (Sc-2), biodiesel and glycerol were generated from the planktonic biomass, and biogas was produced from the residual biomass. The process also involved using a catalyst derived from snail shells for biodiesel production. The third scenario (Sc-3) was similar to Sc-2 but converted CO₂ from the biogas upgrading to methanol, which was then used in synthesizing biodiesel. The results indicated that Sc-2 and Sc-3 had a reduced potential (up to 60 % less) for damaging human health compared to Sc-1. Sc-2 and Sc-3 had up to 61 % less environmental impact than Sc-1. Sc-2 and Sc-3 reduced the total cumulative exergy demand by up to 44 % compared to Sc-1. In conclusion, producing chemicals and utilities within the biorefinery could significantly improve environmental sustainability, reduce waste, and diversify revenue streams.

01 Jun 2023·Case Studies in Chemical and Environmental Engineering

Life cycle assessment of Tehran Municipal solid waste during the COVID-19 pandemic and environmental impacts prediction using machine learning

Author: Hadadian, Mobina ; Shekoohiyan, Sakine ; Heidari, Mohsen ; Hosseinzadeh-Bandbafha, Homa

Life cycle assessment and machine learning were combined to find the best option for Tehran's waste management for future pandemics. The ReCipe results showed the waste's destructive effects after COVID-19 were greater than before due to waste composition changes. Plastic waste has changed from 7.5 to 11%. Environmental burdens of scenarios were Sc-1 (increase composting to 50%) > Sc-3 > Sc-4 > Sc-b2 > Sc-5 > Sc-2 (increase recycling from 9 to 20%). The artificial neural network and gradient-boosted regression tree could predict environmental impacts with high R². Based on the results, the environmental burdens of solid waste after COVID-19 should be investigated.

01 Jun 2022·Biomedicine & PharmacotherapyQ2 · MEDICINE

Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells

Q2 · MEDICINE

Article

Author: Solanki, Ashish K ; Kappler, Christiana ; Duncan, Stephen A ; Heslop, Kareem A ; Mills, Catherine ; Burger, Pieter ; Gooz, Monika ; Peterson, Yuri K ; Woster, Patrick M ; Benton, Thomas ; Maldonado, Eduardo N

Voltage dependent anion channels (VDAC) control the flux of most anionic respiratory substrates, ATP, ADP, and small cations, crossing the outer mitochondrial membrane. VDAC closure contributes to the partial suppression of mitochondrial metabolism that favors the Warburg phenotype of cancer cells. Recently, it has been shown that NADH binds to a specific pocket in the inner surface of VDAC1, also conserved in VDAC2 and 3, closing the channel. We hypothesized that binding of small molecules to the NADH pocket, maintain VDAC in an open configuration by preventing closure induced by NADH and possible other endogenous regulators. We screened in silico, the South Carolina Compound Collection SC³ (~100,000 proprietary molecules), using shape-based queries of the NADH binding region of VDAC. After molecular docking of selected compounds, we physically screened candidates using mitochondrial membrane potential (ΔΨm), as an overall readout of mitochondrial metabolism. We identified SC18, as the most potent compound. SC18 bound to VDAC1, as assessed by a thermal shift assay. Short-term treatment with SC18 decreased ΔΨm in SNU-449 and HepG2 human hepatocarcinoma cells. Mitochondrial depolarization was similar in wild type, VDAC1/2, 1/3, and 2/3 double KO HepG2 cells indicating that the effect of SC18 was not VDAC isoform-dependent. In addition, SC18 decreased mitochondrial NADH and cellular ATP production; and increased basal respiration. Long-term exposure to SC18, decreased cell proliferation as determined by wound-healing and cell viability assays. In summary, SC18 is a novel VDAC-targeting small molecule that induces mitochondrial dysfunction and inhibits cell proliferation.

100 Deals associated with Tamrintamab pamozirine

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Indication	Highest Phase	Country/Location	Organization	Date
Platinum-Resistant Ovarian Carcinoma	Phase 1	US	Stemcentrx, Inc.	01 Aug 2015

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02539719 (Pubmed \| Obstet Gynecol Surv)	Phase 1	Platinum-Resistant Ovarian Carcinoma	74	SC-003	gttvmxacxt(qlctleopbz) = a higher response rate in patients with higher DPEP3 expression byyncxqhwo (kfmmnvzxls )	Negative	05 Jun 2020

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