Delving into the Latest Updates on TOC-1 with Synapse

Overview

Basic Info

Drug Type

Monoclonal antibody

Synonyms

TOC-1 monoclonal antibody (Intellect Neurosciences), anti-tau oligomer mAbs (Intellect Neurosciences)

Target-

Action

inhibitors

Mechanism

Peptide aggregation inhibitors

Therapeutic Areas

Nervous System Diseases

Active Indication-

Inactive Indication

Alzheimer Disease

Originator Organization

Northwestern University

Active Organization-

Inactive Organization

Intellect Neurosciences, Inc.

Northwestern University

Drug Highest PhasePendingDiscovery

First Approval Date-

Regulation-

We determined the effect of dietary tocopherols and tocotrienols on the lipid stability of pre-cooked chicken breast and thigh. The birds were supplemented with one of two doses of a commercial mixture of tocopherols and tocotrienols (Oryza1, Oryza2) or one of two doses of all-rac α-tocopherol acetate (Toc1, Toc2). Diets were formulated so that Oryza1 and Toc1 and Oryza2 and Toc2 contained similar tocopherol concentrations. No quantifiable amounts of tocotrienols were found in either breast or thigh muscles. Tocotrienols present in the diet reduced muscle α-tocopherol concentration. The effect of Oryza1 on the tocopherol content in muscle and on its lipid stability was not significant. The Oryza2, Toc1 and Toc2 diets increased the α- and γ-tocopherol in breast and thigh muscles and enhanced their lipid stability. This improvement was only due to the antioxidant action of the tocopherols. Lipid stability of pre-cooked chicken was not enhanced by adding tocotrienols to a tocopherol supplement.

100 Deals associated with TOC-1

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Alzheimer Disease	Discovery	United States	Intellect Neurosciences, Inc.	-
Alzheimer Disease	Discovery	United States	Northwestern University	-

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Clinical Result

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Biosimilar

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