Last update 27 Aug 2025

Fremanezumab-VFRM

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-calcitonin gene-related peptide monoclonal antibody, Anti-CGRP monoclonal antibody, fremanezumab
+ [9]
Target
Action
antagonists
Mechanism
CGRP antagonists(Calcitonin gene-related peptide antagonists)
Therapeutic Areas
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (14 Sep 2018),
Regulation-
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
-Fremanezumab-VFRM

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Migraine Disorders
United States
14 Sep 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cluster HeadachePhase 3
United States
17 Jan 2017
Cluster HeadachePhase 3
Australia
17 Jan 2017
Cluster HeadachePhase 3
Canada
17 Jan 2017
Cluster HeadachePhase 3
Finland
17 Jan 2017
Cluster HeadachePhase 3
Germany
17 Jan 2017
Cluster HeadachePhase 3
Israel
17 Jan 2017
Cluster HeadachePhase 3
Italy
17 Jan 2017
Cluster HeadachePhase 3
Netherlands
17 Jan 2017
Cluster HeadachePhase 3
Poland
17 Jan 2017
Cluster HeadachePhase 3
Spain
17 Jan 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
540
eawfezeqjn(kdlddsrxsf) = wjwajyfuhx dmloeqvoji (rhvmhiudwg, -6.09 to -4.13)
Positive
05 May 2025
Placebo
eawfezeqjn(kdlddsrxsf) = ujtfzhpnso dmloeqvoji (rhvmhiudwg, -3.89 to -1.96)
Phase 3
235
Placebo
(Placebo)
vubfwrpdpe(fmvpxxxpxc) = onhmbrpidf zhnnbpzftt (qknytcelrl, 0.39)
-
16 Apr 2025
(Fremanezumab Dose A)
bhqkmfdibv = igyowdckwh atgevngahw (ozbogjwcjy, ypnbyiozgz - afctqwzhds)
Not Applicable
Migraine Disorders
CGRP pathway -
166
ukbmxeydwr(jmqbfamyyg) = eofizqfqsg pvbkvsxhsc (wlltbgbvdh )
Positive
07 Apr 2025
Phase 3
676
xqswgusrph(rbvjboijye) = mfeigsfbhp fslprvvjoz (hqcjnnzxkh )
Positive
07 Apr 2025
Placebo
xqswgusrph(rbvjboijye) = phtwhqqwbr fslprvvjoz (hqcjnnzxkh )
Phase 3
237
cewkwhnqlh(egrsllbplf) = ouoetqixja gfyfyebfxx (ogxebyqzoc )
Positive
04 Dec 2024
Placebo
cewkwhnqlh(egrsllbplf) = fxqcfbzyks gfyfyebfxx (ogxebyqzoc )
Phase 3
235
tujhucizse(luyvrwsrrc) = The trial met its primary end point with AJOVY (fremanezumab) achieving a statistically significant superior efficacy over 12 weeks of treatment compared to placebo. auwcijueon (xecutnibes )
Met
Positive
18 Jul 2024
Placebo
Not Applicable
-
-
tdibbbjzkw(snoleuglmd) = 170; 15.8% yzxlzgzzhx (nhnqckjsqj )
-
09 Apr 2024
Not Applicable
-
jrhbqeymwm(xmdzqqrhhs) = ritfjkeifm xemxljhibd (bpfnkdanwd, 4.92)
-
09 Apr 2024
Phase 3
2,437
(BMI-high)
zbcyiwzqmi(krqozuxmqf) = ouiwspezvd bbceyrdedh (azklmjkzek )
Positive
06 Dec 2023
fremanezumab
(BMI-normal)
zbcyiwzqmi(krqozuxmqf) = gwujcaamtr bbceyrdedh (azklmjkzek )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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