Delving into the Latest Updates on MaiZhiLing with Synapse

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms-

Target-

Action-

Mechanism-

Therapeutic Areas

Cardiovascular DiseasesDigestive System DisordersOther Diseases

Active Indication

HemorrhoidsThrombophlebitisVaricose Veins+ [1]

Inactive Indication-

Originator Organization

Cesra Arzneimittel GmbH & Co. KG

Active Organization

Cesra Arzneimittel GmbH & Co. KG

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

China (02 Mar 2009),

HemorrhoidsThrombophlebitisVaricose Veins+ [1]

Regulation-

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OBJECTIVETo observe the clinical efficacy of "Huayu Jiedu Shengjing Decoction" (HJSD) in the treatment of varicocele (VC)-induced asthenospermic infertility and its action mechanism.METHODSUsing computer-generated random numbers, we equally divided 88 patients meeting the study criteria into an experimental and a control group, the former treated orally with HJSD plus or minus, while the latter with Maizhiling Tablets and levocarnitine, both for a course of 12 weeks. After medication, we obtained TCM syndrome scores, sperm motility, sperm DNA fragmentation index (DFI), the seminal cord venous ultrasonographic index, and levels of nitric oxide (NO), reactive oxygen species (ROS) and superoxide dismutase (SOD) in the seminal plasma from the patients, compared the therapeutic effects between the two groups, and analyzed the correlation among the obtained parameters.RESULTSThe total effectiveness rate was dramatically higher in the experimental than in the control group (86.04% vs 73.74%, P < 0.01). The TCM syndromes scores, sperm motility, sperm DFI, and seminal plasma NO, ROS and SOD were all more significantly improved in the former than in the latter group (P < 0.05).CONCLUSIONHuayu Jiedu Shengjing Decoction can improve semen quality and reduce TCM syndrome scores without adverse reactions in patients with VC-induced asthenospermic infertility, which may be attributed to its effect of improving antioxidation and local blood flow.

100 Deals associated with MaiZhiLing

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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hemorrhoids	China	Cesra Arzneimittel GmbH & Co. KG	02 Mar 2009
Thrombophlebitis	China	Cesra Arzneimittel GmbH & Co. KG	02 Mar 2009
Varicose Veins	China	Cesra Arzneimittel GmbH & Co. KG	02 Mar 2009
Venous Thromboembolism	China	Cesra Arzneimittel GmbH & Co. KG	02 Mar 2009