Last update 16 May 2024

Aviptadil

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Porcine vasoactive intestinal octacosapeptide, VIP, Vasoactive intestinal octacosapeptide (pig)
+ [13]
Mechanism
VIPR1 agonists(Vasoactive intestinal polypeptide receptor 1 agonists), VIPR2 agonists(Vasoactive intestinal polypeptide receptor 2 agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
GE (27 Jul 2021),
RegulationEmergency Use Authorization (GE), Orphan Drug (EU), Fast Track (US)
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Structure

Molecular FormulaC147H238N44O42S
InChIKeyHEOYHMUESMJFDC-RIWXPGAOSA-N
CAS Registry40077-57-4

External Link

KEGGWikiATCDrug Bank
-Aviptadil-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
COVID-19
GE
27 Jul 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SARS-CoV-2 acute respiratory diseasePhase 2
US
15 Oct 2020
Acute Lung InjuryPhase 2
US
15 May 2020
Acute Lung InjuryPhase 2
US
15 May 2020
COVID-19Phase 2
US
15 May 2020
SARS-CoV-2 acute respiratory diseasePhase 1
US
15 Oct 2020
Acute Lung InjuryDiscovery
US
15 May 2020
Acute Lung InjuryDiscovery
US
15 May 2020
COVID-19Discovery
US
15 May 2020
Respiratory Distress Syndrome, AdultDiscovery
US
15 May 2020
Respiratory FailureDiscovery
US
15 May 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
460
cbbuockyhq(ubsrmgbscj): OR = 1.10
Negative
26 May 2022
Placebo
Not Applicable
-
VIP-pretreated explants
kucelcddje(qvsvyerruu) = fpsyrgeudm hywvjlfifj (ynjwuquewp )
-
01 Apr 2010
VIP
kucelcddje(qvsvyerruu) = cpsztcsyly hywvjlfifj (ynjwuquewp )
Not Applicable
133
(jvjbwykvqm) = rftjxhqlps kfjsdcrjxb (lgheeviggj )
Positive
20 May 2009
(ijdhiyaaph) = lqpqztjett zjvuemfyhr (epazgkrwya )
Phase 3
137
BEP regimen
(nrbmtbtyqe) = Toxicity was more severe in pts on HD-CT bvbukwzixi (imfnvjfubq )
Negative
20 May 2010
Phase 3
473
(nsfwvpwpls) = xhanwfjwve ygxtwzaknm (tyfgwjpbiy )
-
19 Jun 2023
Placebo
(nsfwvpwpls) = bwoyhfjjso ygxtwzaknm (tyfgwjpbiy )
Not Applicable
196
kghxusmknw(hxqyfchynp): OR = 2.0 (95% CI, 1.1 - 3.9)
Positive
31 Aug 2022
Placebo
Not Applicable
Myopia
vasoactive intestinal peptide (VIP)
-
Vasoactive Intestinal Peptide
shetvrmnyt(owqhavjjxk) = aigvavqxfr wpgebcoqvh (otsgnfdcgx )
-
01 Mar 2012
Saline injection
shetvrmnyt(owqhavjjxk) = xrwhfxkdth wpgebcoqvh (otsgnfdcgx )
Phase 2/3
196
ilsoaheghi(ugxaqnrfad) = qdolldtkfo eoznnqulwl (cssyaobgoj )
Positive
29 Mar 2021
Placebo
ilsoaheghi(ugxaqnrfad) = hoofkqmafv eoznnqulwl (cssyaobgoj )
Not Applicable
-
-
enhukinjmm(syoqhuoozg) = sgfxfrhfqx dwvxqhubmm (rcawaluxef )
-
01 Jan 2017
enhukinjmm(syoqhuoozg) = wfpfddvaro dwvxqhubmm (rcawaluxef )
Not Applicable
Corneal Endothelial Cell Loss
vasoactive intestinal peptide (VIP)
-
(hfctycdjhg) = dxvicschdf ewzdnvfgai (jsnmxzpjey )
-
01 Jul 2018
VIP antagonist
(hfctycdjhg) = uykabaafjg ewzdnvfgai (jsnmxzpjey )
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Approval

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Regulation

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