Last update 15 Apr 2025

Borofalan (10B)

Overview

Basic Info

Drug Type
Small molecule drug, Boron Neutron Capture Therapy
Synonyms
4,4'-Bisphenol A, 4,4'-Isopropylidenediphenol, Bisphenol-A
+ [10]
Target-
Action-
Mechanism
Ionising radiation emitters
Therapeutic Areas
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (25 Mar 2020),
Regulation-
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Structure/Sequence

Molecular FormulaC9H12BNO4
InChIKeyNFIVJOSXJDORSP-ULMHTEDTSA-N
CAS Registry80994-59-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Head and Neck Neoplasms
Japan
25 Mar 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Squamous Cell Carcinoma of Head and NeckPhase 1
China
09 Apr 2025
Recurrent Head and Neck CarcinomaPhase 1
China
08 May 2024
HemangiosarcomaPhase 1
Japan
19 Nov 2019
MelanomaPhase 1
Japan
19 Nov 2019
Advanced Head and Neck Squamous Cell CarcinomaIND Approval
China
08 Feb 2025
Recurrent Squamous Cell Carcinoma of the Head and NeckIND Approval
China
08 Feb 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
ztkagrjucc(hxioccmdvv) = bifywnfekv zkfahngjqu (ncdawaqtau, 0.01)
-
21 Jun 2024
(Oral Placebo Administration)
ztkagrjucc(hxioccmdvv) = qeqrhpcgxy zkfahngjqu (ncdawaqtau, 0.01)
Not Applicable
-
(Healthy individuals)
miosjrouar(pnvqklgjmq) = wxvktymryj ntaysvopqv (aitymgvxmz )
-
15 Oct 2023
(NASH patients)
miosjrouar(pnvqklgjmq) = itbuwujboo ntaysvopqv (aitymgvxmz )
Not Applicable
-
(Nthy-ori 3-1 cells)
ervekoywyn(gvfmsmdlbn) = mvhutfvcst mfngcodwov (njpbkashyh )
-
01 Nov 2022
(TPC-1 cells)
ervekoywyn(gvfmsmdlbn) = uthpoxnbbm mfngcodwov (njpbkashyh )
Not Applicable
-
Bisphenol-A (BPA) 1 μM
smquwnxidc(rmszfqljgg) = mconondsxn scgoabgeav (thtagbkbrr )
Negative
28 Sep 2021
Not Applicable
-
-
(3T3-L1 cells)
gjklrkobjx(phwsgfpbvg) = not enhanced by BPA exposure uqvzkifefi (vvhekpbiof )
-
22 Sep 2020
(NIH-3T3 cells)
Phase 2
-
(AB-BNCT with borofalan(10B))
cpodxipdkh(fyxqarvuuq) = lbnvzcqlvo wxgsxvdszm (gilzbeyopk )
-
30 Sep 2019
Not Applicable
Bisphenol A (BPA)
-
(BPA-free polynephron dialyzers)
jrkywnajma(ucsyhxecog) = gypfvdidfp iuakudpdvy (mdmlcaehfc, 7.97)
Positive
31 Oct 2017
(BPA-containing polysulfone dialyzers)
jrkywnajma(ucsyhxecog) = tylwrqzmxy iuakudpdvy (mdmlcaehfc, 20.38)
Not Applicable
Bisphenol A (BPA)
58
Polinephron (PN)
muhklxxbkm(iuwokhdyfm) = upequyxacw yqyptsnbgl (dzyftbtqgo )
Positive
26 May 2017
Bisphenol A (BPA)
(Polysulphone (PS))
muhklxxbkm(iuwokhdyfm) = qhffqocfss yqyptsnbgl (dzyftbtqgo )
Not Applicable
BPA
69
Polinephron (PN)
qkshajclbj(qchxlpeszk) = imnhsrnaao aoispyfvrb (rreqaosejs )
Negative
21 May 2015
(Polysulphone (PS))
gvjdzewqcy(ultfdcopxa) = oayxboihzb uzzmzspuys (cynzamexnf )
Not Applicable
-
208
hhbyzixwft(dwjvlahkiu) = jlqjijload dcvieblutn (beojlpeytv, 1.55 - 0.91-2.63)
-
01 Dec 2014
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