Borofalan (10B)

Researchers found more unique bacteria taxa in children of normal weight than in overweight or obese children. The findings suggest that BPA exposure could promote different microbial communities in normal weight children than those in children with obesity or who are overweight. A synthetic chemical called Bisphenol A, or BPA, is widely used in the production of durable plastic products including eyewear, water bottles and epoxy resins. But it's also an endocrine disruptor, which means that it can interfere with normal hormone functions in the body. Studies suggest that high levels of exposure may be detrimental to human health in a variety of ways; it may also alter the gut microbiome. But the connections aren't clear. Researchers in Spain recently studied a group of over 100 children to identify microbes that play a role in BPA exposure and degradation, with the larger goal of understanding the complicated relationship between that process and childhood obesity. In their study, published this week in mSystems, the researchers found more unique bacteria taxa in children of normal weight than in overweight or obese children. The findings suggest that BPA exposure could promote different microbial communities in normal weight children than those in children with obesity or who are overweight. "We found that the gut microbial community responds differently to BPA exposure depending on the BMI (body-mass index) of the individual," said microbiologist Margarita Aguilera, Ph.D., at the University of Granada in Spain. Aguilera is a senior author on the study. Those connections, she said, "underscore the intricate interplay between gut microbiota and potential human pathophysiology resulting from cumulative BPA exposure." Previous studies have investigated symptoms and effects associated with BPA exposure. Others have used mouse models and 16S rRNA gene sequencing, which can reveal microbes in complex mixtures of materials, like those from the gut or water. For the new study, the researchers, including Ana López-Moreno, Ph.D., who led the experimental work as part of her doctoral thesis, instead combined analyses of cultured samples with amplicon sequencing -- an approach that, to their knowledge, hasn't been used before. The results came from a study of 106 children in Spain, roughly half boys and half girls, all between the ages of 5 and 10. They had participated in the OBEMIRISK project, an effort to understand the interplay between BPA and the gut microbiome sponsored by the European Food Safety Authority. Sixty of the children were normal weight; the rest were either overweight or obese. Fecal samples from the children were exposed to several levels of BPA and allowed to incubate for 3 days. Then, the researchers used 16s rRNA sequencing and amplicon sequencing, ultimately identifying 333 BPA-resistant bacterial species. Notably, species of Clostridium and Romboutsia found in the BPA-cultured samples promoted the richness of microbiota communities. Generally, Aguilera's team noted, normal-weight children hosted a more diverse, enriched and structured network of bacteria than those found in the groups of overweight and obese children. Those results, she said, suggest that the gut microbiota in normal-weight children may be more resilient when exposed to xenobiotic substances like BPA. Knowing which microbes participate in the complex network connecting BPA, obesity and the gut microbiome, Aguilera said, could point to future interventions and policy changes that may reduce the risk of childhood obesity worldwide. In future work, she said the researchers plan to similarly investigate how exposure to other synthetic chemicals, including parabens and phthalates, may influence the composition of the gut microbiome. Her group's overarching goal, however, is to elucidate the mechanisms behind an invisible but widespread threat. "We want to raise awareness about the health risks associated with microplastics that enter our bodies, and those that circulate in the environment," Aguilera said. "It's crucial for individuals to be mindful of these concerns."

TUESDAY, Jan. 16, 2024 -- Plastics exposure contributes substantially to disease costs in the United States, according to a study published online Jan. 11 in the Journal of the Endocrine Society . Leonardo Trasande, M.D., from the NYU Grossman School of Medicine in New York City, and colleagues calculated the attributable disease burden and cost due to chemicals used in plastic materials in 2018. The researchers identified plastic-related fractions of 97.5 percent for bisphenol A, 98 percent for di-2-ethylhexylphthalate, 100 percent for butyl phthalates and benzyl phthalates, 98 percent for polybrominated diphenylether (PBDE)-47, and 93 percent for perfluoroalkyl substances (PFAS). In a sensitivity analysis, the total estimate of plastic-attributable disease burden in 2018 ranged from $226 billion to $289 billion, with the majority of these costs arising from PBDE exposure. Additionally, an estimated $66.7 billion was due to phthalate exposure and $22.4 billion was due to PFAS exposure. "Plastics contribute substantially to disease and associated social costs in the United States, accounting for 1.22 percent of the gross domestic product. The costs of plastic pollution will continue to accumulate as long as exposures continue at current levels," the authors write. "Actions through the Global Plastics Treaty and other policy initiatives will reduce these costs in proportion to the actual reductions in chemical exposures achieved." Abstract/Full Text Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions. Posted January 2024 More news resources FDA Medwatch Drug Alerts Daily MedNews News for Health Professionals New Drug Approvals New Drug Applications Drug Shortages Clinical Trial Results Generic Drug Approvals Subscribe to our newsletter Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.