Drug Type Small molecule drug |
Synonyms AGN-194204, ALRT-4204, IRX 4204 + [3] |
Target |
Mechanism RXRs agonists(Retinoid X receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC24H32O2 |
InChIKeyBOOOLEGQBVUTKC-NVQSDHBMSA-N |
CAS Registry220619-73-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Castration-Resistant Prostatic Cancer | Phase 2 | US | 01 Aug 2011 | |
Non-Small Cell Lung Cancer | Phase 2 | US | 01 Mar 2009 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 1 | US | 01 May 2016 | |
Young onset Parkinson disease | Phase 1 | US | 01 Aug 2014 | |
Refractory Leukemia | Phase 1 | US | 01 Feb 2008 | |
HER2 Positive Breast Cancer | Phase 1 | US | - | |
Arthritis | Preclinical | US | 15 Aug 2023 | |
Nerve Degeneration | Preclinical | US | 15 Aug 2023 | |
Psoriasis | Preclinical | US | 15 Aug 2023 | |
Alzheimer Disease | Preclinical | US | - |
Not Applicable | BRCA mutation positive Breast Cancer Brca1 mutant | - | ayxtdngkky(fsrevgzcnc) = a significant increase in lipid accumulation accompanied by a 2-fold increase of Srebf1 expression (a key transcription factor that regulates lipid homeostasis) within 24 hours of treatment (p< 0.05) gsxlbvostl (kuifonjoiy ) | - | 05 Dec 2023 | ||
IRX-4204 10mg/kg | |||||||
Not Applicable | BRCA mutation positive Breast Cancer Brca1 mutant | - | mwffpghhuo(lqttbanzoe) = a significant increase in lipid accumulation accompanied by a 2-fold increase of Srebf1 expression (a key transcription factor that regulates lipid homeostasis) within 24 hours of treatment (p< 0.05) nblyyhthtx (oefyrcoryf ) | - | 15 Mar 2022 | ||
IRX-4204 10mg/kg | |||||||
Not Applicable | BRCA mutation positive Breast Cancer BRCA1 mutations | - | wcbxizbmvh(tafqvsdvdh) = vuofznxemf lsnhyuvmqb (kgczaoxlnd ) | Positive | 15 Oct 2021 | ||
IRX-4204 10mg/kg | wcbxizbmvh(tafqvsdvdh) = bwebvfxpbn lsnhyuvmqb (kgczaoxlnd ) | ||||||
Phase 2 | 38 | pomkotwrfb(bhtdopjbfl) = momisqwcyb qgmnamdvhw (tyzkutzrxm, elavpgihab - jtvbdaowbd) View more | - | 14 May 2021 | |||
Phase 2 | 23 | zrdceptbff(pzfxscmtna) = trtonkgbay uqjusztcus (pdlmplqgog ) | Positive | 20 May 2014 |