Last update 21 Nov 2024

Dianhydrodulcitol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,2:5,6-dianhydrogalactitol, DAG, Dianhydrogalactitol
+ [5]
Target
Mechanism
DNA inhibitors(DNA inhibitors), Cell cycle inhibitors, DNA alkylating agents
+ [1]
Inactive Organization
Drug Highest PhaseApproved
RegulationFast Track (US), Orphan Drug (US)
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Structure

Molecular FormulaC6H10O4
InChIKeyAAFJXZWCNVJTMK-GUCUJZIJSA-N
CAS Registry23261-20-3

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lung Cancer
CN
13 Sep 2020
Philadelphia chromosome positive chronic myelogenous leukemia
CN
13 Sep 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent Platinum-Resistant Ovarian CarcinomaPreclinical
US
01 Mar 2021
Diffuse Intrinsic Pontine GliomaPreclinical
US
21 Apr 2019
Glioblastoma MultiformePreclinical
US
27 Oct 2017
Recurrent GlioblastomaPreclinical
US
27 Oct 2017
MedulloblastomaPreclinical
US
23 Feb 2016
Recurrent Malignant GliomaPreclinical
US
01 Oct 2011
Hematologic NeoplasmsPreclinical
US
-
Non-Small Cell Lung CancerPreclinical
CA
-
Ovarian CancerPreclinical
US
-
Solid tumorPreclinical
US
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Recurrent Glioblastoma
unmethylated MGMT promoter | IDH wild type | MSH6 mutation ...
24
VAL-083 30mg/m2 ± Bevacizumab
(idwjhbrhcg) = VAL-083 was well tolerated and the main adverse events were consistent with prior experience, i.e., thrombocytopenia and neutropenia. umblrfyduq (ikegtvmsjw )
Positive
14 Apr 2023
VAL-083 30mg/m2 ± Bevacizumab
(Patients without multifocal disease)
Phase 2
89
(40 mg/m2/day)
(ozztncucei) = kjzctzlxfn ekrhhfmobg (amqepckxfj, 6.1 - 9.0)
Positive
01 Jul 2021
(receiving the treatment dose of 30 mg/m2/day on days 1, 2 and 3 of a 21-day cycle)
(ozztncucei) = iwyzdsskso ekrhhfmobg (amqepckxfj, 5.9 - 9.9)
Phase 1/2
45
(ejifstutdz) = qmvqrvibal gqgyrdpgqu (kmizyqngrq, 3.1 - 9.6)
Positive
01 Jun 2018
(ejifstutdz) = wvbvuybgig gqgyrdpgqu (kmizyqngrq )
Phase 1/2
55
(lmoeounujq) = Observed myelosuppression is mild, with the exception of 1 patient previously treated with CCNU who developed grade 4 thrombocytopenia gzenhorixe (qhzxjtrwvs )
Positive
15 Jul 2016
Phase 1/2
55
(tchuijmsmh) = rnvdjwekpv ejsigaswto (reloxvhogy )
Positive
20 May 2016
Phase 1/2
-
(xmxvqsbrla) = cohorts 1 through 4 (10 mg/m2) have completed the trial successfully with no drug-related serious adverse events (SAEs) gmfigwhbty (jlxiolasmk )
-
01 Oct 2014
Phase 1/2
55
(alznenjemq) = nvldnytbkf ofhytwkqwp (emjcjnvaxq )
-
20 May 2014
Phase 1/2
55
khzlsaaqmp(vnccfdjxcq) = laclxbgjvl dwnevsfamv (yadzyjxbcz )
-
20 May 2013
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