Delving into the Latest Updates on Sodium selenate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

Mechanism

Akt-1 inhibitors(Serine/threonine-protein kinase AKT inhibitors), PP2A stimulants(Protein phosphatase 2A stimulants), Phosphatidylinositol 3-kinase family inhibitors

Therapeutic Areas

Nervous System DiseasesEndocrinology and Metabolic DiseaseEye Diseases+ [1]

Active Indication

Frontotemporal DementiaSupranuclear Palsy, ProgressiveAlzheimer Disease+ [1]

Inactive Indication-

Originator Organization

Velacor Therapeutics Pty Ltd.

Active Organization

Monash University

University of MelbourneJSW Lifesciences GmbH

Inactive Organization

Velacor Therapeutics Pty Ltd.

Drug Highest PhasePreclinical

First Approval Date-

RegulationOrphan Drug (EU)

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Structure

Molecular FormulaH2NaO4Se

InChIKeyPRKRTJSKTGAVMH-UHFFFAOYSA-N

CAS Registry13410-01-0

View All Structures (2)

Author: Ali, Idrish ; Moshe ́, Solomon L. ; Liu, Wei ; Cloyd, James C. ; Casillas‐Espinosa, Pablo M. ; O'Brien, Terence J. ; Jones, Nigel C. ; Li, Chenxu ; Mishra, Usha ; Silva, Juliana ; Coles, Lisa D. ; Yamakawa, Glenn ; Hudson, Matt ; Chi, Tina ; Saletti, Patricia Grandizoli ; Galanopoulou, Aristea S. ; Shultz, Sandy R.

AbstractPost‐traumatic epilepsy (PTE) is a life‐long complication of traumatic brain injury (TBI). The development of PTE is associated with neurological morbidity and increases the risk of mortality. An aim of EpiBioS4Rx (Epilepsy Bioinformatics Study for Antiepileptogenic Therapy) was to test potential therapies to prevent the development of PTE in the lateral fluid percussion injury (LFPI) rat model of TBI, in which rats were subjected to injury at the left parietal cortex. Sodium selenate has been reported to be antiepileptogenic post‐TBI in rodent models by activating protein phosphatase 2A and reducing phosphorylated tau (p‐tau) protein. We aimed to characterize the pharmacokinetics (PK) and brain uptake of sodium selenate using naïve control and LFPI rats. Rats received either a single bolus dose or a single bolus dose followed by a 7‐day subcutaneous minipump infusion of sodium selenate. Sodium selenate and selenium concentrations in plasma and brain were analyzed and used for PK estimation and brain exposure assessment. Selenium concentrations rapidly increased after sodium selenate administration, demonstrating biotransformation from sodium selenate to selenium. Sodium selenate and selenium PK parameters were estimated using non‐compartmental analysis. Sodium selenate clearance (CL/F) and volume of distribution (Vd/F) varied by dose and route of administration, suggesting differences in bioavailability and nonlinear pharmacokinetics at the doses tested. Brain‐to‐plasma partition coefficients (AUCbrain/AUCplasma) for sodium selenate and selenium were found to be 0.7–1.3 and 0.1–0.3 following single‐dose injection, respectively, indicating active transport of sodium selenate across the blood–brain barrier (BBB).

01 Oct 2024·Environmental Pollution

Selenate simultaneously alleviated cadmium and arsenic accumulation in rice (Oryza sativa L.) via regulating transport genes

Article

Author: Tao, Yanjin ; Wan, Yanan ; Huang, Siyu ; Fan, Yu ; Wang, Qi ; Li, Huafen ; Liu, Zhe ; Qi, Hao ; Wang, Qiqi

Cadmium (Cd) and arsenic (As) have contrasting biogeochemical behaviors in paddy soil, which posed an obstacle for reducing their accumulation in rice (Oryza sativa L.) simultaneously. In this study, selenate exhibited a more effective ability than selenite on simultaneous alleviation of Cd and As accumulation in rice under Cd-As co-exposure, and the mechanisms need to be further investigated. The results showed that selenate significantly decreased the root Cd and As contents by 59%-83% and 43%-72% compared to Cd-As compound exposure, respectively. Correspondingly, it significantly down-regulated the expression of uptake-related genes OsNramp5 (87.1%) and OsLsi1 (95.5%) in rice roots. Decreases in Cd (64.5%) and As (16.2%) contents in shoots were also found after selenate addition. Moreover, selenate may promoted the reduction of As(V) to As(Ⅲ) and As(III) efflux to the external medium, resulting in decreased As accumulation and As(Ⅲ) proportion in rice shoots and roots. In addition, selenate could promote the binding of Cd (by 14%-24%) and As (by 9%-15%) in the cell wall, and significantly reduced the oxidative stress by elevating levels of antioxidant enzymes (by 10%-105%) and thiol compounds (by 6%-210%). Additionally, selenate significantly down-regulated the expression of OsNramp1 (49.3%) and OsLsi2 (82.1%) associated with Cd and As transport in rice. These findings suggest selenate has the potential to be an effective material for the simultaneous reduction of Cd and As accumulation in rice under Cd-As co-contamination.

01 Sep 2024·Journal of Environmental Sciences

Effect of inorganic arsenic in paddy soil on the migration and transformation of selenium species in rice plants

Article

Author: Wang, Ze ; Zhu, Xi ; Li, Hong ; Fu, Fengfu ; Wang, Kaiteng ; Yang, Guidi ; Ying, Kaiyang ; Qu, Can ; Wu, Yongchen ; Pokhrel, Ganga Raj

Selenium (Se) in paddy rice is one of the significant sources of human Se nutrition. However, the effect of arsenic (As) pollution in soil on the translocation of Se species in rice plants is unclear. In this research, a pot experiment was designed to examine the effect of the addition of 50 mg As/kg soil as arsenite or arsenate on the migration of Se species from soil to indica Minghui 63 and Luyoumingzhan. The results showed that the antagonism between inorganic As and Se was closely related to the rice cultivar and Se oxidation state in soil. Relative to the standalone selenate treatment, arsenite significantly (p < 0.05) decreased the accumulation of selenocystine, selenomethionine and selenate in the roots, stems, sheaths, leaves, brans and kernels of both cultivars by 21.4%-100.0%, 40.0%-100.0%, 41.0%-100%, 5.4%-96.3%, 11.3%-100.0% and 26.2%-39.7% respectively, except for selenocystine in the kernels of indica Minghui 63 and selenomethionine in the leaves of indica Minghui 63 and the stems of indica Luyoumingzhan. Arsenate also decreased (p < 0.05) the accumulation of selenocystine, selenomethionine and selenate in the roots, stems, brans and kernels of both cultivars by 34.9%-100.0%, 30.2%-100.0%, 11.3%-100.0% and 5.6%-39.6% respectively, except for selenate in the stems of indica Minghui 63. However, relative to the standalone selenite treatment, arsenite and arsenate decreased (p < 0.05) the accumulation of selenocystine, selenomethionine and selenite only in the roots of indica Minghui 63 by 45.5%-100.0%. Our results suggested that arsenite and arsenate had better antagonism toward Se species in selenate-added soil than that in selenite-added soil; moreover, arsenite had a higher inhibiting effect on the accumulation of Se species than arsenate.

100 Deals associated with Sodium selenate

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	A12CE01	DB11068

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Alzheimer Disease	Phase 2	AU	Velacor Therapeutics Pty Ltd.	-
Frontotemporal Dementia	Preclinical	AU	Monash University	11 Oct 2024
Supranuclear Palsy, Progressive	Preclinical	AU	Monash University	13 Oct 2023
Epilepsy	Preclinical	AU	Monash University	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


AAIC2021	Not Applicable	Dementia	12	Sodium selenate 15mg tds	zmxgfshpuk(xqjknluwto) = n=3 vppnlhsllu (tavabrgvza ) View more	-	31 Dec 2021
AAIC2020	Not Applicable	Frontotemporal Dementia	15	Sodium selenate 15mg	(xilkqdecny) = n=4 ekoromscjz (cwnnhriuup ) View more	-	07 Dec 2020