Delving into the Latest Updates on Sodium selenate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

Mechanism

Akt-1 inhibitors(Serine/threonine-protein kinase AKT inhibitors), PP2A stimulants(Protein phosphatase 2A stimulants), Phosphatidylinositol 3-kinase family inhibitors

Therapeutic Areas

Nervous System DiseasesEndocrinology and Metabolic DiseaseEye Diseases+ [1]

Active Indication

Frontotemporal DementiaSupranuclear Palsy, ProgressiveAlzheimer Disease+ [1]

Inactive Indication-

Originator Organization

Velacor Therapeutics Pty Ltd.

Active Organization

Monash University

University of MelbourneJSW Lifesciences GmbH

Inactive Organization

Velacor Therapeutics Pty Ltd.

Drug Highest PhasePreclinical

First Approval Date-

RegulationOrphan Drug (EU)

Login to view timeline

Structure

Molecular FormulaH2NaO4Se

InChIKeyPRKRTJSKTGAVMH-UHFFFAOYSA-N

CAS Registry13410-01-0

View All Structures (2)

Cadmium (Cd) and arsenic (As) have contrasting biogeochemical behaviors in paddy soil, which posed an obstacle for reducing their accumulation in rice (Oryza sativa L.) simultaneously. In this study, selenate exhibited a more effective ability than selenite on simultaneous alleviation of Cd and As accumulation in rice under Cd-As co-exposure, and the mechanisms need to be further investigated. The results showed that selenate significantly decreased the root Cd and As contents by 59%-83% and 43%-72% compared to Cd-As compound exposure, respectively. Correspondingly, it significantly down-regulated the expression of uptake-related genes OsNramp5 (87.1%) and OsLsi1 (95.5%) in rice roots. Decreases in Cd (64.5%) and As (16.2%) contents in shoots were also found after selenate addition. Moreover, selenate may promoted the reduction of As(V) to As(Ⅲ) and As(III) efflux to the external medium, resulting in decreased As accumulation and As(Ⅲ) proportion in rice shoots and roots. In addition, selenate could promote the binding of Cd (by 14%-24%) and As (by 9%-15%) in the cell wall, and significantly reduced the oxidative stress by elevating levels of antioxidant enzymes (by 10%-105%) and thiol compounds (by 6%-210%). Additionally, selenate significantly down-regulated the expression of OsNramp1 (49.3%) and OsLsi2 (82.1%) associated with Cd and As transport in rice. These findings suggest selenate has the potential to be an effective material for the simultaneous reduction of Cd and As accumulation in rice under Cd-As co-contamination.

01 Sep 2024·Journal of Environmental Sciences

Effect of inorganic arsenic in paddy soil on the migration and transformation of selenium species in rice plants

Article

Author: Wang, Ze ; Li, Hong ; Zhu, Xi ; Fu, Fengfu ; Wang, Kaiteng ; Yang, Guidi ; Ying, Kaiyang ; Qu, Can ; Wu, Yongchen ; Pokhrel, Ganga Raj

Selenium (Se) in paddy rice is one of the significant sources of human Se nutrition. However, the effect of arsenic (As) pollution in soil on the translocation of Se species in rice plants is unclear. In this research, a pot experiment was designed to examine the effect of the addition of 50 mg As/kg soil as arsenite or arsenate on the migration of Se species from soil to indica Minghui 63 and Luyoumingzhan. The results showed that the antagonism between inorganic As and Se was closely related to the rice cultivar and Se oxidation state in soil. Relative to the standalone selenate treatment, arsenite significantly (p < 0.05) decreased the accumulation of selenocystine, selenomethionine and selenate in the roots, stems, sheaths, leaves, brans and kernels of both cultivars by 21.4%-100.0%, 40.0%-100.0%, 41.0%-100%, 5.4%-96.3%, 11.3%-100.0% and 26.2%-39.7% respectively, except for selenocystine in the kernels of indica Minghui 63 and selenomethionine in the leaves of indica Minghui 63 and the stems of indica Luyoumingzhan. Arsenate also decreased (p < 0.05) the accumulation of selenocystine, selenomethionine and selenate in the roots, stems, brans and kernels of both cultivars by 34.9%-100.0%, 30.2%-100.0%, 11.3%-100.0% and 5.6%-39.6% respectively, except for selenate in the stems of indica Minghui 63. However, relative to the standalone selenite treatment, arsenite and arsenate decreased (p < 0.05) the accumulation of selenocystine, selenomethionine and selenite only in the roots of indica Minghui 63 by 45.5%-100.0%. Our results suggested that arsenite and arsenate had better antagonism toward Se species in selenate-added soil than that in selenite-added soil; moreover, arsenite had a higher inhibiting effect on the accumulation of Se species than arsenate.

01 Jul 2024·Protoplasma

Selenium nanoparticles conferred drought tolerance in tomato plants by altering the transcription pattern of microRNA-172 (miR-172), bZIP, and CRTISO genes, upregulating the antioxidant system, and stimulating secondary metabolism

Article

Author: Ebadi, Mostafa ; Ahmadvand, Rahim ; Iranbakhsh, Alireza ; Neysanian, Maryam ; Ardebili, Zahra Oraghi

Drought stress is one of the major limiting factors for the production of tomato in Iran. In this study, the efficiency of selenate and Se nanoparticle (SeNP) foliar application on tomato plants was assessed to vestigate mitigating the risk associated with water-deficit conditions. Tomato plants were treated with SeNPs at the concentrations of 0 and 4 mg L^-1; after the third sprays, the plants were exposed to water-deficit conditions. The foliar spraying with SeNPs not only improved growth, yield, and developmental switch to the flowering phase but also noticeably mitigated the detrimental risk associated with the water-deficit conditions. Gene expression experiments showed a slight increase in expression of microRNA-172 (miR-172) in the SeNP-treated plants in normal irrigation, whereas miR-172 displayed a downregulation trend in response to drought stress. The bZIP transcription factor and CRTISO genes were upregulated following the SeNP and drought treatments. Drought stress significantly increased the H₂O₂ accumulation that is mitigated with SeNPs. The foliar spraying with Se or SeNPs shared a similar trend to alleviate the negative effect of drought stress on the membrane integrity. The applied supplements also conferred drought tolerance through noticeable improvements in the non-enzymatic (ascorbate and glutathione) and enzymatic (catalase and peroxidase) antioxidants. The SeNP-mediated improvement in drought stress tolerance correlated significantly with increases in the activity of phenylalanine ammonia-lyase, proline, non-protein thiols, and flavonoid concentrations. SeNPs also improved the fruit quality regarding K, Mg, Fe, and Se concentrations. It was concluded that foliar spraying with SeNPs could mitigate the detrimental risk associated with the water-deficit conditions.

100 Deals associated with Sodium selenate

Login to view more data

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	A12CE01	DB11068

R&D Status

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Frontotemporal Dementia	Preclinical	AU	Monash University	11 Oct 2024
Supranuclear Palsy, Progressive	Preclinical	AU	Monash University	13 Oct 2023
Epilepsy	Preclinical	AU	Monash University	-
Alzheimer Disease	Discovery	AU	Velacor Therapeutics Pty Ltd.	-

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


AAIC2021	Not Applicable	Dementia	12	Sodium selenate 15mg tds	wkmrmucpes(lcqzqeighc) = n=3 vfjiuaeoqo (csvulqimgj ) View more	-	31 Dec 2021
AAIC2020	Not Applicable	Frontotemporal Dementia	15	Sodium selenate 15mg	(qetckdjzar) = n=4 qhmplhuyjb (yscclzwkua ) View more	-	07 Dec 2020