Delving into the Latest Updates on Sodium selenate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

Akt-1 x PI3Ks x PP2A

Action

inhibitors, stimulants

Mechanism

Akt-1 inhibitors(Serine/threonine-protein kinase AKT inhibitors), PP2A stimulants(Protein phosphatase 2A stimulants), PI3K family inhibitors(Phosphatidylinositol 3-kinase family inhibitors)

Therapeutic Areas

Nervous System DiseasesEndocrinology and Metabolic DiseaseEye Diseases+ [1]

Active Indication

Frontotemporal DementiaSupranuclear Palsy, ProgressiveAlzheimer Disease+ [1]

Inactive Indication-

Originator Organization

Velacor Therapeutics Pty Ltd.

Active Organization

JSW Lifesciences GmbH

Monash University

University of Melbourne

Inactive Organization

Velacor Therapeutics Pty Ltd.

Drug Highest PhasePreclinical

First Approval Date-

RegulationOrphan Drug (European Union)

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Structure/Sequence

Molecular FormulaH2NaO4Se

InChIKeyPRKRTJSKTGAVMH-UHFFFAOYSA-N

CAS Registry13410-01-0

View All Structures (2)

In this biosafety risk assessment project, the molecular and physiological responses of chicory seedlings to the introduction of selenate (0, 0.1, 0.5, 1, and 5 mgl^-1) or nanoscale red elemental Se product (nSe) into the culture medium were investigated. The application of nSe at low concentrations improved the fresh weight of shoots and roots, while 5 mgl^-1 nSe caused severe phytotoxicity. Molecular analysis confirmed partially different epigenetic responses to nSe and selenate. DNA hypomethylation is an important mechanism by which Se exerts its influence at the pre-transcriptional level. With increasing nSe concentration, the transcription factor DREB1A (dehydration-responsive element-binding) showed a linear upward trend. The use of nSe contributed to the transcriptional upregulation of the genes for phenylalanine ammonia-lyase (PAL), hydroxycinnamoyl-CoA: quinate-hydroxycinnamoyl transferases (HQT) and hydroxycinnamoyl-CoA: shikimate/quinate-hydroxycinnamoyl transferase (HCT). Proline concentrations were increased in both leaves and roots in response to the nano-supplement. Cytotoxicity of Se at toxic concentrations decreased protein levels, in contrast to the positive nSe treatments, 0.1 and 0.5. Notably, nSe supplementation acted as an efficient elicitor, stimulating the accumulation of phenylpropanoid derivatives, including caffeic acid, chlorogenic acid, and cichoric acid metabolites. The concentration of ascorbate and glutathione displayed a similar upward trend in response to the nSe supplementation. Further comprehensive comparative molecular studies in different stress-sensitive and tolerant species are necessary to gain a better understanding of the underlying mechanisms. This will allow for the optimization of functional protocols for nSe-based supplements to meet the expectations of sustainable agriculture.

01 Feb 2025·Chemistry & Biodiversity

Selenium Enhances Growth, Phenolic Compounds, Antioxidant Capacity in Brassica Oleracea Var. Italica

Article

Author: Soltani, Forouzandeh ; Wiesner‐Reinhold, Melanie ; Babalar, Mesbah ; Saeedi, Mahboobeh ; Baldermann, Susanne ; Mastinu, Andrea

AbstractSelenium is a micronutrient element that is beneficial for the growth and development of plants. It has antioxidant, anticancer, and antiviral properties that are essential for human and animal health. Low‐consumption mineral elements such as selenium can be included in the diet from various sources. To investigate the growth and phytochemical attributes of a broccoli cultivar “Heracklion”, an experiment with five levels of selenium concentration (0, 5, 10, 15, 20 mg/L sodium selenate) was carried out in a randomized complete block design with 3 replications in the field condition. With increasing the concentration of sodium selenate in the foliar application, the accumulation of sodium selenate in broccoli increased and the highest amount (1.47 mg/kg dry weight) was measured at 20 mg/L of sodium selenate. The highest amount of photosynthetic pigments in leaves was recorded at 15 mg/L of sodium selenate. In the case of glucosinolates, with increasing selenium concentration up to 20 mg/L concentration, glucoraphanin, 4‐methoxy glucobrassicin, and aliphatic glucosinolates increased in leaves. It could be demonstrated that foliar application of selenium at 10 mg/L led to an improvement of secondary metabolites, especially glucoraphanin, both in leaves and florets, and could also have a positive effect on human nutrition.

01 Jan 2025·Journal of Environmental Management

Effects of selenate on greenhouse gas release and microbial community variations during swine manure composting

Article

Author: Zhao, Mengxiang ; Ren, Xiuna ; Zhao, Jiarui ; Ding, Yongzhen ; Qin, Yilang ; Xi, Bin ; Xiao, Ziling ; Wang, Quan

Co-composting of livestock manure and selenate is an effective means to produce selenium-rich organic fertilizer. However the effect of selenate on greenhouse gas emission during composting is still unknown. To probe the influences of selenate on greenhouse gas and microbial community changes during swine manure composting. Various dose of selenate were added to the fresh swine manure and wheat straw for 80 days aerobic composting, sequentially labeled as T1 (control) to T6 (0, 1, 2, 3, 4 and 5 mg kg^-1). Results indicated that selenate generally increased the nitrous oxide (N₂O) and ammonia (NH₃) emissions while presented varying impacts on methane (CH₄) emissions. Compared with the control, adding 2 and 5 mg kg^-1 selenate reduced the CH₄ emission by 39.60% and 13.75%, respectively, while other concentrations presented opposite results. Meanwhile, adding 2 mg kg^-1 selenate could reduce the global warming potential and improve the compost maturity. According to the microbial results, adding 2 mg kg^-1 selenate enhanced the richness and variety of the microbes and might influence Proteobacteria, Chloroflexi, Actinobacteria and Methylococcaceae_unclassified to decrease the global warming potential.

100 Deals associated with Sodium selenate

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	A12CE01	DB11068

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Frontotemporal Dementia	Preclinical	Australia	Monash University	11 Oct 2024
Supranuclear Palsy, Progressive	Preclinical	Australia	Monash University	13 Oct 2023
Epilepsy	Preclinical	Australia	Monash University	-
Alzheimer Disease	Discovery	Australia	Velacor Therapeutics Pty Ltd.	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


AAIC2021	Not Applicable	Dementia hyperphosphorylated tau	12	Sodium selenate 15mg tds	conzfhcfda(sscqvxuyft) = n=3 czhwfusejx (rhfywsyjyv ) View more	-	31 Dec 2021
AAIC2020	Not Applicable	Frontotemporal Dementia hyperphosphorylated tau	15	Sodium selenate 15mg	(gdvukbqntj) = n=4 rwinejzyjw (avdjsgymie ) View more	-	07 Dec 2020