Last update 21 Nov 2024

Levofolinate Calcium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Calcium Levofolinate, Calcium Levofolinate Hydrate, Calcium levofolinate (INN)
+ [10]
Target
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors), DNA synthesis inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (16 Jun 1999),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC20H23CaN7O7
InChIKeyBZPWXVJDMRBCMD-QNTKWALQSA-N
CAS Registry80433-71-2
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Small intestine carcinoma
JP
21 Sep 2018
Pancreatic Cancer
JP
20 Dec 2013
Colorectal Cancer
CN
-
Stomach Cancer
CN
-
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colonic CancerPreclinical
JP
01 Oct 2002
recurrent gastric cancerPreclinical
JP
01 May 2002
Recurrent Non-Small Cell Lung CancerDiscovery-01 Apr 2013
MucositisDiscovery-01 Mar 2013
Non-Hodgkin's lymphoma refractoryDiscovery-01 Mar 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
823
(Group P; mFOLFOX6 + Panitumumab Combination Therapy)
dxkpvjwxgt(ryyreewnwh) = zoqbamgktu ekzyujqqqw (dqqtuxkqvv, dxadranief - kotddobpma)
-
01 Nov 2023
(Group B; mFOLFOX6 + Bevacizumab Combination Therapy)
dxkpvjwxgt(ryyreewnwh) = wwlavbbdbz ekzyujqqqw (dqqtuxkqvv, xwftfrakzd - uqmhyidhip)
Phase 2
164
isggkduphz(bsfpszdeug) = aurtqlqqey jfnhhdjejp (pubvqurbfj, bnqspkviwu - neawqisyzn)
-
01 Mar 2019
isggkduphz(bsfpszdeug) = hnbgyccnbk jfnhhdjejp (pubvqurbfj, bvkevqkmee - snzdpxrcql)
Phase 1
6
ubpeurzzxh(cnnxuurles) = igygwguiky fegxtafwpq (emssaavuoz, yxtroffavi - edsxluajhh)
-
06 Oct 2014
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Regulation

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