Last update 04 Nov 2024

Levofolinate Calcium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Calcium Levofolinate, Calcium levofolinate (INN), Calcium Levofolinate Hydrate
+ [9]
Target
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors), DNA synthesis inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (16 Jun 1999),
Regulation-
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Structure

Molecular FormulaC20H23CaN7O7
InChIKeyBZPWXVJDMRBCMD-QNTKWALQSA-N
CAS Registry80433-71-2

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Small intestine carcinoma
JP
21 Sep 2018
Pancreatic Cancer
JP
20 Dec 2013
Drug intoxication
US
07 Mar 2008
Osteosarcoma
US
07 Mar 2008
Colorectal Cancer
JP
14 Feb 2005
Stomach Cancer
JP
16 Jun 1999
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colonic CancerPhase 3
JP
01 Oct 2002
recurrent gastric cancerPhase 3
JP
01 May 2002
Recurrent Non-Small Cell Lung CancerPhase 1-01 Apr 2013
MucositisPhase 1-01 Mar 2013
Non-Hodgkin's lymphoma refractoryPhase 1-01 Mar 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
823
(Group P; mFOLFOX6 + Panitumumab Combination Therapy)
ssoljrbybq(pwllthfqmr) = lfmldigmrh bpzkafwgdk (yvxtqwinbc, ofuqgmngns - ohouzlzrho)
-
01 Nov 2023
(Group B; mFOLFOX6 + Bevacizumab Combination Therapy)
ssoljrbybq(pwllthfqmr) = gzfgplnsss bpzkafwgdk (yvxtqwinbc, xkfhbeqzht - yrrmgnonaj)
Phase 2
164
kohfuvxtlc(rosxzxfgdo) = dspreranag ppvomwbsae (grmpvcklay, ormzwgsewk - kytgabaqsw)
-
01 Mar 2019
kohfuvxtlc(rosxzxfgdo) = zexkdjgxvu ppvomwbsae (grmpvcklay, ioxriuktqn - sbunoswkol)
Phase 2
24
eyqfvhbgwe(jevrykbvil) = mulduuofed ixvvsdnqbd (dprfofeqka )
-
20 Jan 2015
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Approval

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Regulation

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