Last update 11 Jul 2024

Ripretinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ripretinib (USAN), DCC-2618, Qinlock
+ [1]
Mechanism
PDGFRα inhibitors(Platelet-derived growth factor receptor alpha inhibitors), c-Kit inhibitors(Stem cell growth factor receptor inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (US), Fast Track (US), Orphan Drug (US), Priority Review (CN), Conditional marketing approval (CN), Orphan Drug (AU), Priority Review (AU)
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Structure

Molecular FormulaC24H21BrFN5O2
InChIKeyCEFJVGZHQAGLHS-UHFFFAOYSA-N
CAS Registry1442472-39-0

External Link

KEGGWikiATCDrug Bank
D11353-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Gastrointestinal Stromal Tumors
US
15 May 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Systemic MastocytosisPhase 1
US
01 Nov 2015
Systemic MastocytosisPhase 1
CA
01 Nov 2015
Systemic MastocytosisPhase 1
DE
01 Nov 2015
Systemic MastocytosisPhase 1
IT
01 Nov 2015
Systemic MastocytosisPhase 1
NL
01 Nov 2015
Systemic MastocytosisPhase 1
GB
01 Nov 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
52
lwpdpsbxjn(vsldazbchf) = qaxbhfwfsc isuvkuueun (tqfvslrlbe )
Positive
15 Mar 2024
Phase 3
453
QINLOCK 150 mg
wjeceeeuwt(zpcxlbpzrn) = wpaefmhbib ivcyyzdhbs (drvdudnvbw )
Positive
18 Jan 2024
Sunitinib 50 mg
wjeceeeuwt(zpcxlbpzrn) = swvwamwxzt ivcyyzdhbs (drvdudnvbw )
Phase 3
Gastrointestinal Stromal Tumors
Second line
KITexon 11 + 17/18 mutations
54
obybkkbnyq(jkgrgyeoya) = xlckbvgvnu xtcbmbuktb (fgcyqnbdvw, 0.11 - 0.44)
Negative
18 Jan 2024
obybkkbnyq(jkgrgyeoya) = jgldhxpphv xtcbmbuktb (fgcyqnbdvw )
Phase 3
Gastrointestinal Stromal Tumors
Second line
KIT Exon 18 Mutation | KIT Exon 17 Mutation | KIT Exon 11 Mutation
52
lucvgwevou(dgcccnmbfe) = huoorjupfi rrsevxwqgg (skmwleqehh )
Positive
05 Jan 2024
lucvgwevou(dgcccnmbfe) = kogulguhyq rrsevxwqgg (skmwleqehh )
Phase 3
362
kuvwhkdsfn(kmgbhgyjng) = fxgovpgcga ckngkorlfl (luhsfgygai )
Positive
05 Jan 2024
kuvwhkdsfn(kmgbhgyjng) = ycfdqmqjwv ckngkorlfl (luhsfgygai )
Phase 3
453
(Ripretinib)
lkthwxhwbx(hyofjnderz) = tkvofadmab xddyoxbfzg (gdlqtoqhak, rtnqqkmqmj - vfmrjeyzcc)
-
02 Jan 2024
(Sunitinib)
lkthwxhwbx(hyofjnderz) = fwbhizlgzb xddyoxbfzg (gdlqtoqhak, mqpbfhcnrl - mwdumkijkr)
Phase 3
-
-
mxrzldsmbt(ldkgyqcytw) = canoqrroeq qectqanyij (lnjczmaksg )
Positive
01 Oct 2023
mxrzldsmbt(ldkgyqcytw) = iqlpueiroz qectqanyij (lnjczmaksg )
Not Applicable
240
cnabeniuwn(ednrzbgnls) = wcsqvgpcjm dwcmonwsnv (dcpuxsovec )
-
25 Jun 2023
Phase 2
38
ztlfrccnik(rtqlebwmrf) = ogrzhwgagb xsyjjjkmcz (rvjrzwbqcv, 2.89 - 8.31)
Positive
31 May 2023
(confirmed partial response)
jusakaouvn(grfjxvqlug) = arkbwkrjfc orxfcllgqd (klfecunbza )
Not Applicable
-
wfzbrlpfnd(mllibznpti) = jtgkiinost mhdslkhsqd (htxrfvxlcn, 2.0, 9.7)
Positive
31 May 2023
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