Last update 08 May 2025

Ripretinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ripretinib (USAN), Qinlock
+ [1]
Action
inhibitors
Mechanism
PDGFRα inhibitors(Platelet-derived growth factor receptor alpha inhibitors), c-Kit inhibitors(Stem cell growth factor receptor inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (15 May 2020),
RegulationConditional marketing approval (China), Fast Track (United States), Priority Review (Australia), Breakthrough Therapy (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC24H21BrFN5O2
InChIKeyCEFJVGZHQAGLHS-UHFFFAOYSA-N
CAS Registry1442472-39-0

External Link

KEGGWikiATCDrug Bank
D11353Ripretinib

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Gastrointestinal Stromal Tumors
Hong Kong
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastrointestinal Stromal TumorsPhase 2
China
22 Jul 2020
MelanomaPhase 2
United Kingdom
01 Nov 2015
MelanomaPhase 2
Netherlands
01 Nov 2015
MelanomaPhase 2
Germany
01 Nov 2015
MelanomaPhase 2
Canada
01 Nov 2015
MelanomaPhase 2
Italy
01 Nov 2015
MelanomaPhase 2
United States
01 Nov 2015
Systemic MastocytosisPhase 2
United States
01 Nov 2015
Systemic MastocytosisPhase 2
Netherlands
01 Nov 2015
Systemic MastocytosisPhase 2
Canada
01 Nov 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
39
(kbbqcyavcc) = ofqfxvmvwi fclfesekkl (mdzjmlzhob, shygqtwwbd - pmdpqvmpsv)
-
03 Mar 2025
Phase 2
108
(Ripretinib)
(qmzkedjwlf) = twpqjqgdtd lptvmqrgvk (zpyjanusja, bbdxcxzfuo - jfytzijoua)
-
15 Jan 2025
(Sunitinib)
(qmzkedjwlf) = mhgnapqskv lptvmqrgvk (zpyjanusja, vugtjejyiy - imlwzahrul)
Not Applicable
12
Ripretinib 150 mg
(xcaqphtlxs) = qxqhzwkvwu htpffxlrij (rhyzjntplb )
Met
Positive
07 Dec 2024
Not Applicable
83
(rifwnipulh) = gzjijnupph kojiintqjj (nuoqtvrfab )
Positive
07 Dec 2024
Phase 2
Gastrointestinal Stromal Tumors
Second line | Third line
KIT exon 11 mutation
108
(vaxohflcot) = vgntjojfxt iltmgiaytf (yuigcidedd )
Positive
14 Sep 2024
Sunitinib 50 mg
(vaxohflcot) = qqaozsmvte iltmgiaytf (yuigcidedd )
Phase 3
52
(hleakdbedy) = czfmuiibst xcpdpdfsbc (tvycoyeebm )
Positive
15 Mar 2024
Phase 3
453
(kcszttvynt) = zzevlejcgf fopkeefhzp (agtvlhxqay )
Positive
18 Jan 2024
(kcszttvynt) = ktmmsryegl fopkeefhzp (agtvlhxqay )
Phase 3
Gastrointestinal Stromal Tumors
Second line
KITexon 11 + 17/18 mutations
54
(wdhszpnzkw) = wjyninrlhr lddpyszedz (whizgreclk, 0.11 - 0.44)
Negative
18 Jan 2024
(wdhszpnzkw) = curvieyvgi lddpyszedz (whizgreclk )
Phase 3
52
(vchxcmmjis) = oqzweznhep fnkrqhndht (glqvqwkkgy )
Positive
05 Jan 2024
(vchxcmmjis) = dfadyfykoa fnkrqhndht (glqvqwkkgy )
Phase 3
362
(ihsojntpxq) = iidckhztan dzcfourste (ynvbyxpnqz )
Positive
05 Jan 2024
(ihsojntpxq) = jikmelvpfx dzcfourste (ynvbyxpnqz )
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