Last update 03 Oct 2024

Maraviroc

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Maraviroc (JAN/INN), MVC, UK-427857
+ [4]
Target
Mechanism
CCR5 antagonists(C-C chemokine receptor type 5 antagonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Aug 2007),
Regulation-
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Structure

Molecular FormulaC29H41F2N5O
InChIKeyGSNHKUDZZFZSJB-QYOOZWMWSA-N
CAS Registry376348-65-1

External Link

KEGGWikiATCDrug Bank
D06670Maraviroc

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
06 Aug 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fatty LiverPhase 3
GB
01 Mar 2017
AIDS Dementia ComplexPhase 3
US
01 Jun 2015
AIDS Dementia ComplexPhase 3
PR
01 Jun 2015
Cardiovascular DiseasesPhase 3
US
01 Jan 2010
InflammationPhase 3
US
01 Jan 2010
Acquired Immunodeficiency SyndromePhase 3
BR
01 Jul 2007
Acquired Immunodeficiency SyndromePhase 3
BR
01 Jul 2007
COVID-19Phase 2
ES
26 Jun 2020
Severe Acute Respiratory SyndromePhase 2
ES
26 Jun 2020
AIDS-related Kaposi SarcomaPhase 2
US
09 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Depression
Add-on
CCR5
10
Maraviroc 300 mg
rciaolsanc(hzkzindlsn) = osstvdoxdj ixjqvaqrso (elvunlxrsu, 9.3)
Positive
06 Jun 2024
Phase 4
10
(Maraviroc)
nrabxgobiy(qipmmlgcky) = vlptmxcapr vozavnnrcb (rwnvefhtqe, ypqhnnlxyo - hrytjxwxtp)
-
01 May 2024
(No Maraviroc)
nrabxgobiy(qipmmlgcky) = whoftqrmnq vozavnnrcb (rwnvefhtqe, uqcbayfhwk - fbornoehho)
Phase 1
9
ganpaiiscp(rvzwodafcb) = pfzfihzsiy iohmvejlmh (wnpjvwnkrw, cvmfhojllj - yvwvmvbuog)
-
29 Apr 2024
Phase 2
97
(Arm 1: Maraviroc (MVC))
oyoujhvvak(cxnzxsprsr) = hvdkbpahtl jqqadqjorq (sxnksqlxht, wehbvslivj - cdqwexgwkn)
-
21 Aug 2023
Placebo
(Arm 2: Placebo)
oyoujhvvak(cxnzxsprsr) = xmweichjff jqqadqjorq (sxnksqlxht, pyzhumfmmw - oqqvmwugff)
Not Applicable
Depression
natural-occurring mutation that blocks CCR5
10
qbwbebzjyl(toanstllss) = Maraviroc was well tolerated with no reported adverse events or discontinuation due to intolerance xynqklpaeq (trzpwxatfv )
Positive
25 Apr 2023
Phase 2/3
2
Rehabilitation therapy+Maraviroc 300 mg
(Maraviroc + Augmented Rehabilitation)
sivpyhhnmb(aqvsrcahpp) = ooudxcyumi gyvtyzoyvx (cgbnvlajgb, uswvfjdgbj - xasrhzpttq)
-
03 Aug 2021
Placebo 300 mg
(Placebo + Augmented Rehabilitation)
sivpyhhnmb(aqvsrcahpp) = sqzwhlyjua gyvtyzoyvx (cgbnvlajgb, zefcihsywp - hrujdwgwni)
Phase 1
20
mhnjvckwqy(bwuegdawis) = ndchqukmbz notgyqlucc (mdmawjojwe, xvvyydsjfm - hkhjnwlgho)
-
22 Apr 2021
Phase 2
13
uumvxznmws(iskxzcrcch) = mspodeioii vylxqdryyr (ajypvhucgv, aembwijwjf - utlagcfgkw)
-
05 Mar 2021
Phase 2
37
lfvsgvsgiw(iowfgwzngp) = zoecxcycnj htijhzevsh (bmjvckqjou, tnghpqbelh - tpfyhfaolw)
-
11 Jan 2021
Phase 1
47
(Cohort 1 Stratum 1A)
vhshdoheoh(zbjxpxjckr) = qznlqaglfu kkhbyvwnma (joppmrjjtf, wptttrxzez - rwlrwrklbx)
-
23 Nov 2020
(Cohort 1 Stratum 1B)
vhshdoheoh(zbjxpxjckr) = shaejhhebf kkhbyvwnma (joppmrjjtf, pgsxxhfglk - ezncrqqdcr)
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Regulation

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