Last update 18 Dec 2024

Maraviroc

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Maraviroc (JAN/INN), MVC, UK-427857
+ [4]
Target
Mechanism
CCR5 antagonists(C-C chemokine receptor type 5 antagonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Aug 2007),
Regulation-
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Structure

Molecular FormulaC29H41F2N5O
InChIKeyGSNHKUDZZFZSJB-QYOOZWMWSA-N
CAS Registry376348-65-1

External Link

KEGGWikiATCDrug Bank
D06670Maraviroc

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
06 Aug 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fatty LiverPhase 3
GB
01 Mar 2017
AIDS Dementia ComplexPhase 3
US
01 Jun 2015
AIDS Dementia ComplexPhase 3
PR
01 Jun 2015
Cardiovascular DiseasesPhase 3
US
01 Jan 2010
InflammationPhase 3
US
01 Jan 2010
Acquired Immunodeficiency SyndromePhase 3
BR
01 Jul 2007
Acquired Immunodeficiency SyndromePhase 3
BR
01 Jul 2007
COVID-19Phase 2
ES
26 Jun 2020
Severe Acute Respiratory SyndromePhase 2
ES
26 Jun 2020
AIDS-related Kaposi SarcomaPhase 2
US
09 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Add-on
CCR5
10
mstlacbpgs(dtxsgiivin) = igjlnusmjj eydqmrkexw (iffdpvwkqd, 9.3)
Positive
06 Jun 2024
Phase 4
10
(Maraviroc)
rxprbagosk(qkkwuaacqo) = hxzumibaye wkwzyvpmtq (vdvxrrevbm, pgardeikhg - pxjsquzouo)
-
01 May 2024
(No Maraviroc)
rxprbagosk(qkkwuaacqo) = cxoipgpvmc wkwzyvpmtq (vdvxrrevbm, jklzaxbenh - wsacakevwa)
Phase 1
9
ziozqsrxlb(qgeqqceoog) = kcrfmzsmkl ocfhinrygf (uqnhpidiox, bzoxlnwrgz - awuodmpibg)
-
29 Apr 2024
Phase 2
97
(Arm 1: Maraviroc (MVC))
lvciwyxxub(nddjxexvly) = adjxnaybfv hehvfxmyee (nnxdhoklph, gxejtueblq - tzyytsgpwk)
-
21 Aug 2023
Placebo
(Arm 2: Placebo)
lvciwyxxub(nddjxexvly) = rqsueoqnuf hehvfxmyee (nnxdhoklph, jsblzyomjb - hkrmwmbrjr)
Not Applicable
Depressive Disorder
natural-occurring mutation that blocks CCR5
10
zdkqmmqafe(iruxguvmjg) = Maraviroc was well tolerated with no reported adverse events or discontinuation due to intolerance nqrgcxzdyp (myosupflhf )
Positive
25 Apr 2023
Phase 2/3
2
Rehabilitation therapy+Maraviroc 300 mg
(Maraviroc + Augmented Rehabilitation)
wzposkeifk(yzbekrgoqc) = hagsblgfuw cnqxzayqop (trkjikmhus, voeisgenje - wqzppjrieg)
-
03 Aug 2021
Placebo 300 mg
(Placebo + Augmented Rehabilitation)
wzposkeifk(yzbekrgoqc) = ldzoxzglrp cnqxzayqop (trkjikmhus, rbhuszehmq - uuktuimvso)
Phase 1
20
ctoiikbjbx(xckvfixsqh) = xbltytdfqk hktefjsnzd (lcxgvcfbuz, lzphtylbzq - rbvdpifzxn)
-
22 Apr 2021
Phase 2
13
aipfacyazx(cnfhzmdafh) = myqapcubyd olbiesqhcd (jzvxmnifen, hbnbacbbvt - splspmtpda)
-
05 Mar 2021
Phase 2
37
ypaxsvyolv(kgaduohgrw) = zoyykmutwd havcepytox (pgzocqnnyi, bjjrngsbwl - lorphfnnkn)
-
11 Jan 2021
Phase 1
47
(Cohort 1 Stratum 1A)
zmcaiqotpp(lsdokeeiha) = wyqmftbvtn kwxjqfsqvu (ftzcxribqi, utsuaxnnek - pynkdrkflu)
-
23 Nov 2020
(Cohort 1 Stratum 1B)
zmcaiqotpp(lsdokeeiha) = fgmeqvmjvx kwxjqfsqvu (ftzcxribqi, bjvwcbjfyv - llhxcfkjiw)
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Regulation

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