Delving into the Latest Updates on Fentanyl Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Fentanyl hydrochloride (JAN), Ionsys

Target

δ opioid receptor x κ opioid receptor x μ opioid receptor

Mechanism

δ opioid receptor agonists(δ-opioid receptor agonists), κ opioid receptor agonists(Kappa opioid receptor agonists), μ opioid receptor agonists(Mu opioid receptor agonists)

Therapeutic Areas

Nervous System Diseases

Active Indication-

Inactive Indication

Pain, Postoperative

Originator Organization

The Medicines Company (Spain) SL

Active Organization-

Inactive Organization

Incline Therapeutics Europe Ltd.Janssen-Cilag International NV

The Medicines Co.

Drug Highest PhaseWithdrawn

First Approval Date

EU (24 Jan 2006),

Pain, Postoperative

Regulation-

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Structure

Molecular FormulaC22H29ClN2O

InChIKeyLHCBOXPPRUIAQT-UHFFFAOYSA-N

CAS Registry1443-54-5

View All Structures (2)

A Prospective, randomized study conducted on 120 pregnant women attending the labour wards in Kasr Al Ainy and Fayoum maternity hospitals from May 2014 to December 2015. All participants were scheduled for elective cesarean section under spinal anaesthesia and were randomly divided into 3 equal groups. Group 1(40 women) received 16 mg Dexamethasone IV drip. Group II (40 women) received 16 mg Dexamethasone subcutaneous injection around the caesarean section scar after skin closure and Group III received Placebo in the form of IV fluids 500 cc saline infusion. All cases were followed up for 48 hours for assessment of level of pain by using a 10-cm visual analog scale (VAS). Primary outcome parameters were VAS score and the need for additional analgesics. Other parameters were hemodynamic changes and occurrence of side effects or complications

Start Date01 May 2014

Sponsor / Collaborator

Cairo University

100 Clinical Results associated with Fentanyl Hydrochloride

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100 Translational Medicine associated with Fentanyl Hydrochloride

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100 Patents (Medical) associated with Fentanyl Hydrochloride

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39

Literatures (Medical) associated with Fentanyl Hydrochloride

02 Aug 2024·Journal of Occupational and Environmental Hygiene

Assessment of glove stretch and storage temperature on fentanyl permeation: Implications for standard test methods and PPE recommendations

Article

Author: Keyes, Patrick H ; Yoon, N Katherine ; Soo, Jhy-Charm ; Greenawald, Lee Ann ; Streeter, Rebecca T ; Fisher, Edward M ; Hofacre, Kent C

The National Institute for Occupational Safety and Health recommends the use of nitrile gloves with a minimum thickness of 5.0 ± 2.0 mil [0.127 ± 0.051 millimeters] in situations where it is suspected or known that fentanyl or other illicit drugs are present. However, there is limited data available on fentanyl permeation through gloves. Current test methods used to measure fentanyl permeation do not consider the effect of glove fit and flexion. Furthermore, first responders need to have PPE readily available in the field, and storage conditions may affect the protective performance of the gloves. The objective of this study was to evaluate the effects of glove stretch and storage temperatures on glove durability and barrier performance against fentanyl. Nine nitrile glove models previously shown to be resistant to fentanyl permeation were selected for this investigation. These nine models were stretched 25% in one linear direction, to consider glove fit and flexion, and tested against fentanyl hydrochloride permeation. Additionally, four of the nine glove models were stored at 48 °C, 22 °C, and -20 °C, and evaluated for tensile strength, ultimate elongation, and puncture resistance after up to 16 wk of storage and fentanyl permeation after up to 8 wk of storage. At least one sample for six of the nine tested models had maximum permeation over the test method fail threshold when stretched. The tested storage temperatures showed no effect on glove tensile strength, ultimate elongation, and puncture resistance. The findings of this study can be used to inform PPE recommendations, with consideration to storage practices and proper sizing for first responders with potential exposure to fentanyl and other illicit drugs. The results of this study can be used to assess the need for new standard test methods to evaluate the barrier performance of gloves and shelf-life determination with consideration to glove fit.

01 Sep 2022·Journal of Forensic Sciences

Characterization of fentanyl HCl powder prior to and after systematic degradation

Article

Author: Simon, Alison G. ; Wagner, Jarrad R. ; Ciesielski, Austin L. ; Welch, Katie

AbstractFentanyl HCl is of particular interest in forensic cases but there is a notable gap in literature regarding its analysis. This study utilized a multi‐method approach to characterize fentanyl HCl powder, both fresh and following a forced degradation process. Using sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) and direct injection gas chromatography–mass spectrometry (GC–MS), five compounds were identified in fresh fentanyl HCl powder. The identified compounds were: N‐phenylpropanamide, 1‐phenethyl‐4‐propionyloxypiperidine (1‐P‐4‐POP), 4‐anilino‐N‐phenethylpiperidine (4‐ANPP), acetylfentanyl, and fentanyl; all identified compounds but acetylfentanyl and fentanyl decreased in quantity as the sample was degraded. Fresh headspace samples analyzed with solid phase microextraction (SPME)‐GC–MS identified four compounds in common with the powder analyses: N‐phenylpropanamide,1‐P‐4‐POP, 4‐ANPP, and fentanyl. Acetylfentanyl was not present in the headspace samples, although two additional compounds were: N‐phenylacetamide and N‐phenethyl‐4‐piperidinone (NPP). Where direct analysis of degraded fentanyl HCl showed decreased quantities of the identified compounds, headspace samples of the degraded fentanyl HCl resulted in higher quantities, implying that the degradation process drove those compounds to volatilize. Notably, fentanyl was identified in the headspace, implying that this could be an appropriate target for standoff detection. Finally, thermogravimetric analysis (TGA) and differential scanning calorimetry (DCS) confirmed that the forced degradation process had little permanent effect on the powder.

24 Jan 2022·American Journal of EpidemiologyQ2 · MEDICINE

Time-Series Analysis of Fentanyl Concentration in the Unregulated Opioid Drug Supply in a Canadian Setting

Q2 · MEDICINE

Article

Author: Richard Laing ; Jane Buxton ; Kenneth W Tupper ; Mark Lysyshyn ; Lianping Ti ; Cameron J Grant ; Evan Wood ; Samuel Tobias ; Jaime Arredondo

AbstractNorth America has been contending with an unregulated street drug supply in which opioids are often adulterated with illicitly manufactured fentanyl. The unpredictability of composition may result in an increased risk of overdose due to unexpected elevated concentrations of the high-potency drug. Using data from a community-based drug-checking project, we evaluated trends in fentanyl concentration of illicit opioids in the context of an overdose epidemic. Using a quantification model for fentanyl hydrochloride, historical Fourier-transform infrared spectra from opioid drug-checking samples were analyzed to determine fentanyl concentrations. Median monthly fentanyl concentrations were plotted, and polynomial and autoregressive time-series analyses were performed to examine trends over time. A total of 3,621 fentanyl-positive samples were included in the study, spanning November 2017 to December 2019. Monthly median fentanyl concentrations ranged from 4.5% to 10.4%. Time-series analyses indicated that a third-degree polynomial model fit the data well (R2 = 0.639), suggesting a cyclical pattern in median concentration over time. Notably, absolute variance in fentanyl concentration decreased by an average 0.1% per month (P < 0.001). Future research should explore the relationship between fentanyl concentration and overdose to identify potential targeted harm-reduction interventions that can respond to changes in observed fentanyl concentration.

100 Deals associated with Fentanyl Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D10811	Fentanyl Hydrochloride	N02AB03 N01AH01	DB00813

R&D Status

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04679818 (CTgov)	Phase 3	Anesthesia \| Drug-Related Side Effects and Adverse Reactions	72	PMD-200 Nol-guided opioid administration (PMD-200 NOL Group)	uunrypjpxp(ussrwkjvyq) = lkqydntopi hzrrgsiren (kkbeueonwj, mxahscjpmk - rwihozmkzg) View more	-	21 Jun 2024
				Routine opioid management (Control Group)	uunrypjpxp(ussrwkjvyq) = kpskmvqorf hzrrgsiren (kkbeueonwj, oijswxwfxb - poyezfnjkq) View more