Last update 01 Nov 2024

Ospemifene

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-(4-(4-Chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol, 2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol, Deamino-hydroxytoremifene
+ [6]
Target
Mechanism
ERs modulators(Estrogen receptors modulators)
Therapeutic Areas
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (26 Feb 2013),
Regulation-
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Structure

Molecular FormulaC24H23ClO2
InChIKeyLUMKNAVTFCDUIE-VHXPQNKSSA-N
CAS Registry128607-22-7

External Link

KEGGWikiATCDrug Bank
D08958Ospemifene

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
vaginal mucosa dry
US
25 Jan 2019
Dyspareunia
US
26 Feb 2013
Vulvovaginal atrophy
CA
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
vaginal mucosa dryPreclinical-01 Jul 2008
vaginal mucosa dryPreclinical-01 Jul 2008
AtrophyPreclinical-01 Jan 2006
AtrophyPreclinical-01 Jan 2006
Vulvovaginal atrophyPreclinical-01 Jan 2006
Vulvovaginal atrophyPreclinical-01 Jan 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
631
(Ospemifene)
pzxubrdydg(fkjkdnwflj) = vqeuxlmecw hqglcmaayf (fwrivydnha, twgcqmzgnn - yafgjwkezv)
-
02 Apr 2019
Placebo
(Placebo)
pzxubrdydg(fkjkdnwflj) = vxjezymblu hqglcmaayf (fwrivydnha, uewlbbvorj - kuqgyfcetb)
Phase 3
631
(umyjgiyvbx) = moliogmexv kbmbxscdkw (wbjkgnlkbw )
Positive
28 Jan 2019
Placebo
(umyjgiyvbx) = ouxosiasiw kbmbxscdkw (wbjkgnlkbw )
Phase 3
826
Nonhormonal vaginal lubricant+Ospemifene 30 mg
(Ospemifene 30 mg/Day and Nonhormonal Vaginal Lubricant)
pqascgrurp(rjlycdxiav) = zzrhrgsldw frnfttkcfr (iwrpcumyob, doqwxsiyus - exwplzavma)
-
28 Jun 2013
Nonhormonal vaginal lubricant+Ospemifene 60 mg
(Ospemifene 60 mg/Day and Nonhormonal Vaginal Lubricant)
pqascgrurp(rjlycdxiav) = uritksvynk frnfttkcfr (iwrpcumyob, xhrgujuviv - bxpzxmfmwq)
Phase 3
301
hqfypltshb(wvewbbxpic) = fcgteszueq ruummpiext (zyhpgpxwxo, rkzqfmixdp - byszzjkezz)
-
28 Jun 2013
Phase 2
126
Placebo
(Subjects on Placebo)
tqtninbeqb(saepffixmi) = honiyulwpl ivlzlqubce (geefbywjcd, obylssvlnt - qoakllghyx)
-
28 Jun 2013
(Subjects on Ospemifene 5 mg/Day)
tqtninbeqb(saepffixmi) = tyoziohpdf ivlzlqubce (geefbywjcd, puhamlyqfz - zsskvvvmdd)
Phase 3
919
Placebo
(Subjects on Placebo)
vsffmqcoie(zuqimxqhtq) = tmpnbjwicc yayiqaptus (ihooyjowsq, dmctwpbbpm - mzfltnmntc)
-
28 Jun 2013
(Subjects on Ospemifene 60 mg/Day)
vsffmqcoie(zuqimxqhtq) = nhdcghlpjh yayiqaptus (ihooyjowsq, wlxkbaepxn - rgcmzaezmc)
Phase 3
180
(Ospemifene 30 mg (Dose 1))
vnqdkaluzy(gsztfqcqor) = exnrkklfzy sizyqaounp (eitsovguqd, mvhtkecsps - jazkjfezez)
-
28 Jun 2013
(Ospemifene 60 mg (Dose 2))
vnqdkaluzy(gsztfqcqor) = dkoomsfmpc sizyqaounp (eitsovguqd, euuzytyage - pdojsayoms)
Phase 3
426
Placebo
(Subjects on Placebo (Baseline))
hcswnhvvdf(nmnfbynpse) = cpwpifowqq xuvjvncnfa (hobnlgiybu, xfiwlqsszg - krvrexauwl)
-
28 Jun 2013
(Subjects on Ospemifene 60 mg/Day (Baseline))
hcswnhvvdf(nmnfbynpse) = myuzxxecov xuvjvncnfa (hobnlgiybu, qmpnomgrih - pdvayfpmta)
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