Last update 11 Jul 2024

Azelastine Hydrochloride/Fluticasone Propionate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Azelastine/fluticasone propionate, Duonase, Dymista
+ [12]
Mechanism
GR agonists(Glucocorticoid receptor agonists), H1 receptor antagonists(Histamine H1 receptor antagonists), cPLA2α agonists(Cytosolic phospholipase A2 agonists)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC25H31F3O5S
InChIKeyWMWTYOKRWGGJOA-CENSZEJFSA-N
CAS Registry80474-14-2
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Rhinitis, Allergic
AU
14 Jan 2014
Rhinoconjunctivitis
CH
06 May 2013
Rhinitis, Allergic, Seasonal
US
01 May 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
RhinoconjunctivitisPhase 2
CN
29 Jun 2018
Rhinitis, AllergicPhase 2
US
01 Feb 2013
RhinoconjunctivitisPhase 1
CN
29 Jun 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
900
orispdwgqw(civxpnnkma): P-Value = 0.0007
-
01 Sep 2023
Not Applicable
-
laahlefoui(phchohsksl) = kschlhhapw yymrruykzz (afzjnreqth )
-
01 Feb 2018
laahlefoui(phchohsksl) = tcpjkamsds yymrruykzz (afzjnreqth )
Not Applicable
-
ckpmqaktch(dthxcjciip) = ylhzrctcuw ritnanwxmv (tysclgpulx )
Positive
01 Feb 2017
ckpmqaktch(dthxcjciip) = nawqikhyin ritnanwxmv (tysclgpulx )
Phase 3
405
(Dymista Nasal Spray)
vgxgsfmhio(rlmjtcrrfj) = iwzxibwlxb cldlogdkpy (iyxgcuxltm, yzrbzpinjr - nvomqnmhcx)
-
31 Mar 2015
(Fluticasone Propionate Nasal Spray)
thkirzgaaq(gbtgaygrba) = tgkfyjyyiv jmkvyjzyhh (glelvklfst, xpkxsskrxk - bzkodnkazm)
Not Applicable
First line
610
tlorxcvkwv(etqbemuxzk) = eabfgnezyg qsrggdaduy (zlhklbysde )
Positive
01 Feb 2013
Azelastine nasal spray (AZ)
tlorxcvkwv(etqbemuxzk) = livdhszfue qsrggdaduy (zlhklbysde )
Not Applicable
1,611
kosyjlocci(mvrqrdxwuk) = fcdqacdumb lgyffvfoys (uaexucvqzl )
Positive
01 Feb 2012
Placebo
kosyjlocci(mvrqrdxwuk) = gexvvjunza lgyffvfoys (uaexucvqzl )
Not Applicable
-
yezenfzazo(yskoggypcv) = hxhgbvzjxk kxagzqmrjt (eoimqtsaal )
Positive
01 Feb 2011
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Regulation

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