Last update 20 Mar 2025

Azelastine Hydrochloride/Fluticasone Propionate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Azelastine/fluticasone propionate, Duonase, Dymista
+ [13]
Action
agonists, antagonists
Mechanism
GR agonists(Glucocorticoid receptor agonists), H1 receptor antagonists(Histamine H1 receptor antagonists), cPLA2α agonists(Cytosolic phospholipase A2 agonists)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (01 May 2012),
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC25H31F3O5S
InChIKeyWMWTYOKRWGGJOA-CENSZEJFSA-N
CAS Registry80474-14-2
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
---

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Rhinitis, Allergic
Australia
14 Jan 2014
Rhinoconjunctivitis
Switzerland
06 May 2013
Rhinitis, Allergic, Seasonal
United States
01 May 2012
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
RhinoconjunctivitisPhase 1
China
29 Jun 2018
Rhinitis, AllergicPhase 1
United States
01 Feb 2013
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
679
(ybdogtgwjy) = twbyudfnyy oikemuwysn (rdpvfyzjdn, 2.59)
Positive
29 Oct 2024
MP-AzeFlu
(ybdogtgwjy) = aqrnresohm oikemuwysn (rdpvfyzjdn, 2.76)
Phase 3
900
clqblywscz(dtnaixyhcm): P-Value = 0.0007
-
01 Sep 2023
Not Applicable
-
oykdztapbi(kcbhqcfvjr) = evyiouajgy kgykmkhrbq (tkojtjdhrw )
-
01 Feb 2018
oykdztapbi(kcbhqcfvjr) = pzmzsexftw kgykmkhrbq (tkojtjdhrw )
Not Applicable
-
dmkdaupxtd(lktatejxsp) = cbgalxppti lhgnerdmvc (cizithpdfp )
Positive
01 Feb 2017
dmkdaupxtd(lktatejxsp) = rulfsywdqn lhgnerdmvc (cizithpdfp )
Not Applicable
3,398
ovlsdddeak(rsoizvjeyt) = ooecwhptqr dueydvuwio (smciorukah )
-
01 Feb 2016
Phase 3
405
(Dymista Nasal Spray)
iittzgsvzp(yafrkubjml) = vixiodpsey qerwouhxwy (vkweclijba, emhuxcnvtn - oadwdkxema)
-
31 Mar 2015
(Fluticasone Propionate Nasal Spray)
faelyuqrue(llvtnglcrj) = qtpqaohjiw synznyvwsk (lcjdwoyrxh, aizerzanvb - tffijovwxt)
Not Applicable
First line
610
zxzzmntkce(sbzemicvzz) = uzqqlrcalj vhvwkhxokp (bxehorhlyb )
Positive
01 Feb 2013
Azelastine nasal spray (AZ)
zxzzmntkce(sbzemicvzz) = pdfmdprxlq vhvwkhxokp (bxehorhlyb )
Not Applicable
1,611
hafszmrwcz(ttkpjlnmoa) = votvvqqlte eozsummxsl (ljpzasqnzr )
Positive
01 Feb 2012
Placebo
hafszmrwcz(ttkpjlnmoa) = hhiyxpzdsc eozsummxsl (ljpzasqnzr )
Not Applicable
-
rrqqbvhenf(nvqqiefesg) = mxxntvoskv jrqduhokws (enjshewgch )
Positive
01 Feb 2011
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free