Delving into the Latest Updates on anti-GPC3 CAR T(Shanghai Renji Hospital) with Synapse

Overview

Basic Info

Drug Type

CAR-T

Synonyms-

Target

GPC3

Mechanism

GPC3 inhibitors(Glypican-3 inhibitors), Immunologic cytotoxicity, T lymphocyte replacements

Therapeutic Areas

NeoplasmsDigestive System Disorders

Active Indication-

Inactive Indication

Hepatocellular Carcinoma

Originator Organization

Shanghai Renji Hospital Management Co., Ltd.

Active Organization-

Inactive Organization

Shanghai Renji Hospital Management Co., Ltd.

Drug Highest PhasePendingPhase 1

First Approval Date-

Regulation-

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This study is designed to determine the safety and efficacy of CAR-GPC3 T cells in patients with relapsed or refractory hepatocellular carcinoma. Single or multiple doses of GPC3-targeted CAR T cells will be given to subjects with unmet medical needs for which there are no effective therapies known at this time.

Start Date17 Mar 2017

Sponsor / Collaborator

Shanghai Renji Hospital Management Co., Ltd.

[+1]

NCT02395250 / CompletedPhase 1

Autologous T Cells Redirected to GPC3 for Treating Patients With Advanced HCC

The purpose of this study is to determine whether autologous T cells bearing chimeric antigen receptor that can specifically recognize glypican-3 (GPC3) is safe and effective for patients with relapsed or refractory hepatocellular carcinoma (HCC).

Start Date01 Mar 2015

Sponsor / Collaborator

Shanghai Renji Hospital Management Co., Ltd.

100 Clinical Results associated with anti-GPC3 CAR T(Shanghai Renji Hospital)

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100 Translational Medicine associated with anti-GPC3 CAR T(Shanghai Renji Hospital)

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100 Patents (Medical) associated with anti-GPC3 CAR T(Shanghai Renji Hospital)

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100 Deals associated with anti-GPC3 CAR T(Shanghai Renji Hospital)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Hepatocellular Carcinoma	Phase 1	CN	Shanghai Renji Hospital Management Co., Ltd.	01 Mar 2015

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02395250 (Literature) Manual	Phase 1	Advanced Hepatocellular Carcinoma	2	anti-GPC3 CAR T	dbdlodyshg(ajzkmavspo) = For case 1: overall survival time more than 8 years; For case 2: disease-free for more than 5 years without any further anticancer treatment and has an overall survival time of over 8 years. ebeindivhm (uecmzqwixv )	Positive	21 Jul 2023