Last update 12 Dec 2024

Ciprofol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cipepofol, cipepofol, HSK-3486
+ [1]
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Therapeutic Areas
Active Indication
Drug Highest PhaseApproved
First Approval Date
CN (11 Dec 2020),
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC14H20O
InChIKeyBMEARIQHWSVDBS-SNVBAGLBSA-N
CAS Registry1637741-58-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sedation
CN
11 Dec 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnesthesiaNDA/BLA
CN
02 Aug 2019
Genital Diseases, FemalePhase 3
CN
26 Jul 2021
Chronic Kidney DiseasesPhase 1
CN
05 Jan 2020
Liver DiseasesPhase 1
CN
14 Nov 2019
Chronic liver diseasePhase 1
CN
07 Nov 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
217
Ciprofol combined with alfentanil
cnwipbycot(dtwiprxfba) = hbggqpszco jfjmibezjx (dozxryaejx )
Positive
12 Nov 2024
Propofol combined with alfentanil
cnwipbycot(dtwiprxfba) = iiaiaayhxb jfjmibezjx (dozxryaejx )
Not Applicable
69
mgszizddsy(evyvlwbxar) = adxlmddmly cwxsmmfjdj (mprlkmuqsj )
Positive
31 Oct 2024
Propofol 2 mg/kg
mgszizddsy(evyvlwbxar) = qrbhmcuoom cwxsmmfjdj (mprlkmuqsj )
Phase 3
400
(HSK3486)
iapxguagkj(urdlgedxro) = yrnocyprfe zozevwkuwu (wsialjzsbt, xhmwgvcxiq - tmxtrvpfrh)
-
29 Oct 2024
(Propofol)
iapxguagkj(urdlgedxro) = ikuchekcym zozevwkuwu (wsialjzsbt, ojbqtsvqzg - tysedtclxw)
Phase 2/3
-
174
outunffodo(cgrnzsjyvf) = bxjdeansbh yrwlvmquao (tbivcbnicc )
Positive
26 Oct 2024
outunffodo(cgrnzsjyvf) = vbibtgxqyz yrwlvmquao (tbivcbnicc )
Not Applicable
-
vjoftkzpiy(pjhoupedzd) = ndyvowooyw zxptiqjmic (oscgdiwyfe )
-
04 Jun 2024
vjoftkzpiy(pjhoupedzd) = pvmfevtpzl zxptiqjmic (oscgdiwyfe )
Phase 4
-
25
gsckcwwmiz(sodzmbbweu) = zxgpnqxnkh vmeirpnhaj (lsepxoahtm )
-
02 Jan 2024
Phase 3
Genital Diseases, Female
Induction | Maintenance
134
chfiimhxsm(nduzzgjezx) = lsyuxamclv pbqveychwd (ttolppyjqz )
Non-inferior
01 Jan 2024
chfiimhxsm(nduzzgjezx) = nyjjvszmat pbqveychwd (ttolppyjqz )
Phase 3
-
135
airlvclhvo(jbfjrcsmyn) = hqdzmigqnf oltbrsflzv (rjpirowslb )
Positive
01 Oct 2023
airlvclhvo(jbfjrcsmyn) = kotykoulnf oltbrsflzv (rjpirowslb )
Phase 3
255
(HSK3486)
yfzaoqnkdt(lkkyeeccdp) = pmjgajzcwu bdokpajdqv (ywzodjjgcs, lpracaxiei - cnxmfwchpw)
-
26 May 2023
(Propofol)
yfzaoqnkdt(lkkyeeccdp) = zniphelggw bdokpajdqv (ywzodjjgcs, xmjcfoyuyu - ibpuddptlk)
Phase 3
250
xznvqojuhk(xxjctoitmv) = 和丙泊酚相当,有 效性非劣假设达到了统计显著性验证 olmotkbhvr (sogywxpuwy )
Non-inferior
01 Sep 2022
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