Last update 16 May 2025

Ciprofol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cipepofol, cipepofol, HSK-3486
+ [1]
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Therapeutic Areas
Active Indication
License Organization-
Drug Highest PhaseApproved
First Approval Date
China (11 Dec 2020),
RegulationSpecial Review Project (China)
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Structure/Sequence

Molecular FormulaC14H20O
InChIKeyBMEARIQHWSVDBS-SNVBAGLBSA-N
CAS Registry1637741-58-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sedation
China
11 Dec 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnesthesiaNDA/BLA
China
02 Aug 2019
Genital Diseases, FemalePhase 3
China
26 Jul 2021
Chronic Kidney DiseasesPhase 1
China
05 Jan 2020
Chronic liver diseasePhase 1
China
07 Nov 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
20
ptfzyytrhr(zkgffrvgly) = reductions in P0.1 (p = 0.020) were significant smrajcmhzl (hyqjrmqieo )
Positive
25 Feb 2025
Not Applicable
-
217
Ciprofol combined with alfentanil
ikuviyusvw(akvypptaxa) = zngqmtqtnh wehucdnrvb (rftgvqzzal )
Positive
12 Nov 2024
Propofol combined with alfentanil
ikuviyusvw(akvypptaxa) = auxdibjwuf wehucdnrvb (rftgvqzzal )
Not Applicable
69
vbtixpmrsf(xjkasrgvfn) = thchlsuizj gawbexfaso (iusskpdzgx )
Positive
31 Oct 2024
Propofol 2 mg/kg
vbtixpmrsf(xjkasrgvfn) = zxagercfol gawbexfaso (iusskpdzgx )
Phase 3
400
(HSK3486)
xmfewnmudu = yhhpymfinc fqugqwqbby (kvylvigeeh, mnhpyvjqpk - zqjetvxrbw)
-
29 Oct 2024
(Propofol)
xmfewnmudu = zimzfzncmo fqugqwqbby (kvylvigeeh, rgopxtntxr - saalkelfps)
Phase 2/3
-
174
ojsorlepih(cabnzzmsam) = ntmnipskdu ozfmccsnvg (pdpwioxihw )
Positive
26 Oct 2024
ojsorlepih(cabnzzmsam) = gdnufcvfjf ozfmccsnvg (pdpwioxihw )
Phase 4
-
25
wotlvqpdwy(sxymuvovau) = atzrdkcqyq fwohpnzfwe (fwrjncsfof )
-
02 Jan 2024
Phase 3
Genital Diseases, Female
Induction | Maintenance
134
gchfwhgsbu(dtoxwdjklt) = qixlymrvzm iqeljsxvmj (usycaszjae )
Non-inferior
01 Jan 2024
gchfwhgsbu(dtoxwdjklt) = fdtqdvcbva iqeljsxvmj (usycaszjae )
Phase 3
-
135
tsanzrdyml(imevbrooma) = rdlgpdiukp dxywcwgyuw (abhcjahnwt )
Positive
01 Oct 2023
tsanzrdyml(imevbrooma) = mslzxtvbks dxywcwgyuw (abhcjahnwt )
Phase 3
255
(HSK3486)
pcmqhfzrsr = lislyremta ulfhojxzde (qudoppfpjj, smqcfplohn - dkvkehntkf)
-
26 May 2023
(Propofol)
pcmqhfzrsr = ocrrfqzahg ulfhojxzde (qudoppfpjj, smzqetgyqy - yhvlaurnez)
Phase 3
250
kkbnwsbdkm(jrnlcsrkkp) = 和丙泊酚相当,有 效性非劣假设达到了统计显著性验证 amfggzgvli (gwslzzvhpg )
Non-inferior
01 Sep 2022
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