[Translation] A multicenter, randomized, open, parallel controlled phase III clinical trial of local injection of compound aluminum sulfate injection in the treatment of bladder tumors

评价局部注射复方硫酸铝注射液对比TURBT术治疗非肌层浸润性膀胱癌(Ta/T1期)或良性膀胱肿瘤的安全性和有效性。这是一个多中心、随机、开放、平行、非劣效的试验设计。主要关注TURBT手术和复方硫酸铝注射在第三年的复发率的比较。

[Translation]

To evaluate the safety and efficacy of local injection of aluminum sulfate compound injection compared with TURBT for the treatment of non-muscle invasive bladder cancer (Ta/T1 stage) or benign bladder tumors. This is a multicenter, randomized, open, parallel, non-inferiority trial design. The main focus is on the comparison of the recurrence rate between TURBT surgery and aluminum sulfate compound injection in the third year.

Start Date13 Dec 2017

Sponsor / Collaborator

Chinese People's Liberation Army General Hospital

[+1]

100 Clinical Results associated with Compound aluminum sulfate

100 Translational Medicine associated with Compound aluminum sulfate

100 Patents (Medical) associated with Compound aluminum sulfate

183

Literatures (Medical) associated with Compound aluminum sulfate

01 Jun 2024·Heliyon

Experimental approach and analysis of the effectiveness of a tubular helical flow flocculator for water supply in developing communities

Article

Author: Garcia-Avila, Fernando ; Cadme-Tandazo, Jaime ; Aviles-Anazco, Alex ; Cabello-Torres, Rita ; Valdiviezo-Gonzales, Lorgio ; Cadme-Galabay, Manuel

The main objective of this study was to evaluate the impact of the length and retention time of a tubular helical flow flocculator (THFF) on the elimination of turbidity and color from raw water, to obtain quality treated water for consumption in areas rural. For this, a large-scale field experimental system was used, the THFF was built with 4-inch diameter polyethylene hose and coupled to a sedimentation and filtration process. For the different experimental tests, aluminum sulfate was chosen as the coagulant. To find the optimal dose of coagulant, jar tests were previously carried out. For the tests the length of the THFF was varied (50 m and 75 m), flow rates of 0.25, 0.5, 0.75, 1 and 2 L/s and turbidity ranges of <10, 10-20, 21-50, 51-100 and > 100 NTU of raw water were tested. An evaluation of the hydraulic behavior of the THFF was carried out through an analysis of the temporal distribution curve of the concentration of a tracer, applying the Wolf-Resnick model. The average results revealed a haze and color removal efficiency of 98.07 % and 98.50 %, respectively. The residence time and velocity gradient exhibited variations in a range of 2.25-35.0 min and 3.64 to 56.94 s^-1, respectively. It was evident that the operation and effectiveness of THFF are directly influenced by the turbidity of the raw water, the residence time and the velocity gradient. These findings indicate that THFF could play a valuable role as a flocculation unit in a purification system, mainly the existence of a plug-type flow was observed. The findings indicate that THFF, complemented by settling and filtration processes, could be a valuable tool for implementation in rural areas.

17 Apr 2024·Journal of Toxicology and Environmental Health, Part A

How do different concentrations of aluminum and zinc affect the survival, body size, morphology and immune system of Physalaemus cuvieri (Fitzinger, 1826) tadpole?

Article

Author: Pompermaier, Aline ; Folador, Alexandre ; Müller, Caroline ; de Albuquerque, Vagner José ; Hartmann, Marília ; Hartmann, Paulo Afonso

The assessment of amphibian responses as bioindicators of exposure to chemical pollutants is an important tool for conservation of native species. This study aimed to investigate the effects of chronic aluminum (Al) and zinc (Zn) exposure on survival, body size, morphology (malformations), and immune system (leukocyte profile) in P. cuvieri tadpoles. Ecotoxicological analyses were performed utilizing chronic toxicity tests in which 210 tadpoles at the 25^th Gosner developmental stage were exposed to Al and Zn. Individuals of P. cuvieri were maintained in glass containers containing various concentrations of aluminum sulfate (0.1, 0.2, or 0.3 mg/L) and zinc sulfate (0.18, 0.27 or 0.35 mg/L), and tests were performed in triplicate. After 14 days, amphibians were weighed, measured and survival rate, malformations in the oral and intestine apparatus, leukocyte profile, and ratio between neutrophils and lymphocytes determined. The differing concentrations of Al and Zn did not produce lethality in P. cuvieri where 95% of the animals survived 326 hr following metal exposure. Individuals exposed to Zn achieved greater body growth and weight gain compared to controls. Aluminum increased weight gain compared controls. These metals also produced malformations of the oral and intestine apparatus and enhanced occurrence of hemorrhages, especially at the highest doses. Lymphocytes were the predominant cells among leukocytes, with lymphopenia and neutrophilia observed following Al and Zn treatment, as evidenced by elevated neutrophil/lymphocyte ratio, an important indicator of stress in animals. Data suggest that further studies need to be carried out, even with metal concentrations higher than those prescribed by CONAMA, to ensure the conservation of this species.

01 Nov 2023·Waste Management

Activation behavior of the novel CO2 foaming agent for mining on fly ash

Article

Author: Hou, Chengyan ; Yao, Suwan ; Guan, Xuemao ; Guo, Chaoyang ; Zou, Dinghua ; Zhou, Wei ; Pan, Chao ; Wang, Kangkang ; Zhang, Haibo

Although there have been many research results on the chemical activation of fly ash (FA) as a supplementary cementitious material (SCM) in cementitious materials. However, there is a lack of research on the use of CO₂ foaming agent (sodium bicarbonate and potassium aluminum sulfate) to activate fly ash. In this experiment, the effects of CO₂ foaming agent, sodium bicarbonate, and potassium aluminum sulfate on the activity of FA mixed paste were investigated. The mechanism of FA activation by activator was revealed by selective acid dissolution, QXRD, BSE-EDS statistical analysis, and quantitative analysis of TGA. The results showed that the remaining fly ash amounts of MG, SBG, and PASG after 28 days were 17.5%, 25.9%, and 43.3% lower than those of the control group, respectively. In addition, potassium aluminium sulphate promoted hydration to generate more CH to activate the FA. Sodium bicarbonate promoted hydration and produces more CH to activate FA by generating nano-CaCO₃. The mixture of sodium bicarbonate and potassium aluminum sulfate took advantage of both nano-CaCO₃ and potassium aluminum sulfate to promote silicate hydration to provide CH. As a result, the two synergistically activate FA. The above results show that CO₂ foaming agents can be used not only as foaming agents to prepare lightweight materials, but also as chemical activators to activate solid waste. This will have a high practical application value.

100 Deals associated with Compound aluminum sulfate

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Bladder Cancer	Phase 3	CN	Chinese People's Liberation Army General Hospital	13 Dec 2017
Bladder Cancer	Phase 3	CN	Jilin Huakang Pharmaceutical Co. Ltd.	13 Dec 2017
Transitional Cell Carcinoma	Phase 3	CN	Chinese People's Liberation Army General Hospital	13 Dec 2017
Transitional Cell Carcinoma	Phase 3	CN	Jilin Huakang Pharmaceutical Co. Ltd.	13 Dec 2017

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Compound aluminum sulfate

Overview

Basic Info

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation