The objective of this paper is to establish the method for high performance liquid chromatog. determination of danshensu sodium in Shexiangxinnaotong tablet.The condition for high performance liquid chromatog. was Shim-pack C18 column (150 mm × 4.6 mm, 5 μm) with methanol-[water, DMF, glacial acetic acid (93:2:1)] (11.7:88.3) as the mobile phase.The flow rate was 1 mL/min-1 and the detection wavelength was 283 nm.The results showed that the standard curve was liner in the range of 0.516-2.58 μg and the correlation coefficient was 0.999 6.The average recovery was 98.8% with relative standard deviation 0.73%.It was concluded that the method shows good separating result, accuracy, reproducibility, and can be used for the quality control of Shexiangxinnaotong tablet.