Delving into the Latest Updates on Canrenone with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Canrenone (USAN), canrenone

+ [2]

Target

MR

Action

modulators

Mechanism

MR modulators(Mineralocorticoid receptor modulators)

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Hypertension

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC22H28O3

InChIKeyUJVLDDZCTMKXJK-WNHSNXHDSA-N

CAS Registry976-71-6

AbstractIntroductionAsparagus species are naturally distributed worldwide and are known for their pharmacological properties that offer cures for various ailments. However, the metabolic choreography of these Asparagus species is not well characterized, and the compounds contributing to their bioactivities remain unknown.ObjectiveThis study aimed to profile and compare the metabolomes of three Asparagus species cladodes using different solvent extractions.MethodsAn ultra‐high performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry‐based metabolomics and molecular networking approach was used to study the effects of different solvents (ethyl acetate, methanol, and chloroform) with varying polarity on metabolites extraction and identification of bioactive compounds from three Asparagus species cladodes (Asparagus falcatus, Asparagus plumosus, and Asparagus densiflorus ‘Meyersii’).ResultsMultivariate statistical analyses (mainly principal component analysis) revealed a significant separation between the three solvents and the three species, indicating notable metabolic differences. A total of 118 metabolites were identified in the three species extracted with the different solvents, with methanolic and chloroform extracts containing more metabolites compared with ethyl acetate extracts. These metabolites were identified as belonging to the flavonoids, cinnamic acids, organooxygen compounds, steroids, fatty acids, benzenes, and glycerophospholipids compound classes. Furthermore, these compounds classes were differentially distributed among the three species, indicating chemical/chemotaxis differences between the compared species. Chloroform and methanol are recommended as the optimal solvents to obtain a high content of phytochemical compounds from Asparagus species cladodes.

01 Apr 2025·Journal of Food Composition and Analysis

Identification of metabolite biomarkers for distinguishing Korean fresh/frozen and Chinese frozen yellow goosefish (Lophius litulon) using liquid chromatography-Orbitrap mass spectrometry

Author: Yang, Ji-young ; Yang, Junho ; Kang, Seokwon ; Shin, Jiyoung ; Nam, Gangmi

This study aimed to identify metabolite biomarkers to distinguish yellow goosefish based on their distribution origin (Korean or Chinese) and freshness, using liquid chromatog.-Orbitrap mass spectrometry.Fresh and frozen fish samples from both origins were analyzed, resulting in the identification of 213 putative metabolites.Principal component anal. with hierarchical clustering was initially performed to compare all fish groups, focusing on the effects of distribution conditions by comparing fresh and frozen Korean fish.Subsequently, t-test and orthogonal partial least squares discrimination anal. were conducted to calculate the variable importance in projection (VIP) scores of metabolites and evaluate their ability to distinguish between Korean and Chinese fish.The anal. demonstrated an excellent model for distinguishing Korean fresh fish from Chinese frozen fish, with an area under the curve (AUC) ranging from 0.98 to 1.00.Eight compounds exhibited significant differences between Korean and Chinese fish (p < 0.05, VIP > 1.0), with anserine identified as the most robust biomarker for distinguishing between the two groups.The high AUC value of 0.98, derived from the receiver operating characteristic curve, confirmed the effectiveness of anserine as a biomarker.Anserine is proposed as a reliable biomarker for distinguishing yellow goosefish based on their geog. origin.

18 Mar 2025·Analytical Chemistry

Study on the Material Basis and Mechanisms of Achyrocline satureioides in the Treatment of Nonsmall Cell Lung Cancer Based on Network Pharmacology and Spatial Metabolomics

Article

Author: Shen, Duo ; Yan, Dongmei ; Liu, Huihui ; Min, Jianxin ; Yu, Xi ; Chen, Jie ; Han, Jing ; Li, Bin ; Nie, Zongxiu

Achyrocline satureioides have good therapeutic effects on nonsmall cell lung cancer (NSCLC). Nevertheless, it is still challenging to elucidate the active ingredients and mechanism of action due to their complex chemical composition. To address this, we innovatively combined network pharmacology with spatial metabolomics to comprehensively investigate the active components and the action mechanism in the present study. First, metabolomics of cells treated with the methanol extract of A. satureioides (ASM) utilizing high-resolution ultrahigh-performance liquid chromatography tandem mass spectrometry (HR-UHPLC-MS/MS) revealed 32 changed metabolites and 7 enriched metabolic pathways, confirming the anti-NSCLC effect of ASM and its impact on endogenous metabolites at the cellular level. Then, 69 chemical components in the ASM were identified using HR-UHPLC-MS/MS, followed by the screening of 6 core components and 10 core targets of anti-NSCLC with the help of network pharmacology and molecular docking. Lastly, quercetin, the most abundant compound among the six core active ingredients, was chosen for evaluating its anti-NSCLC effect and the potential mechanism using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). 51 altered endogenous metabolites were screened, and pathway enrichment analysis results were consistent with cell metabolomics, corroborating our network pharmacology predictions. In addition, we also observed the accumulation of three metabolites of quercetin in the tumor tissues. Network pharmacology combined with MSI elucidated the metabolic mechanisms by which A. satureioides treats NSCLC, offering new insights into herbal cancer therapies.

100 Deals associated with Canrenone

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External Link

KEGG	Wiki	ATC	Drug Bank
D03363	Canrenone	C03DA03	DB12221

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hypertension	-	-	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


[PP.09.18] (ESH2017)	Not Applicable	Essential Hypertension	-	Canrenone 50 mg/day	vweyeajiml(piltrzacri) = otcfwrnhjr syisjzatib (lojfssdhsi )	Positive	01 Sep 2017
				Canrenone 100 mg/day	vweyeajiml(piltrzacri) = djcchgxhwn syisjzatib (lojfssdhsi )
NCT02687178 (ESCAPE-IT, Pubmed \| Cardiovasc Ther)	Phase 4	Hypertension Add-on	175	Canrenone 50 mg	zmyiufdgbi(pvlrejkmmw) = hbsftomxyh prxnictcbo (ymfmiuwygb ) View more	-	01 Feb 2017
				Canrenone 100 mg	zmyiufdgbi(pvlrejkmmw) = pzkhjsqgbo prxnictcbo (ymfmiuwygb ) View more
NCT00403910 (AREA IN-CHF, Pubmed \| Eur J Heart Fail)	Phase 3	Chronic heart failure	-	Canrenone	(iocmwlekza) = jhroqvrtkr dgemevpnek (zqwragjibv ) View more	-	01 Jan 2009
				Placebo	(iocmwlekza) = cgkjjuzcyk dgemevpnek (zqwragjibv ) View more
NCT00403910 (AREA IN-CHF, Pubmed \| J Cardiovasc Med (Hagerstown))	Phase 3	Chronic heart failure	467	Canrenone	wnwukoqutg(ukrnuvawdk) = hsmfkvoach lpfanlfezl (qdlkxlhtdm ) View more	-	01 Sep 2007
				Placebo	wnwukoqutg(ukrnuvawdk) = wdwrkhasnh lpfanlfezl (qdlkxlhtdm ) View more