Last update 04 Aug 2025

Epacadostat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Epacadostat (JAN/USAN/INN), 71596A9R13 (UNII code), INCB-024360
+ [1]
Target
Action
inhibitors
Mechanism
IDO1 inhibitors(Indoleamine 2,3-dioxygenase inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC11H13BrFN7O4S
InChIKeyFBKMWOJEPMPVTQ-UHFFFAOYSA-N
CAS Registry1204669-58-8

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 3
United States
27 Dec 2017
Recurrent Non-Small Cell Lung CancerPhase 3
United States
27 Dec 2017
Metastatic urothelial carcinomaPhase 3
United States
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Japan
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Australia
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Canada
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Denmark
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
France
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Germany
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Hungary
22 Dec 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
30
(UPS, Liposarcoma or Pleomorphic Liposarcoma)
iyvuuvxqjv = jzszsuxzef ljnpftacqo (ohcrrheuvo, dlhwzanfuy - ckqexnnlrx)
-
02 May 2025
(Leiomyosarcoma)
iyvuuvxqjv = xexdrcbdpz ljnpftacqo (ohcrrheuvo, vvqttoyydh - uzsjykjpfa)
Phase 2
30
(Epacadostat 600 mg BID + Retifanlimab 500 mg Q4W)
bgmcgbsygn = ageysbmcad thvzwpklqz (nxxpjlehst, gvfoahvmsn - bhwocnkczl)
-
10 Mar 2025
(Retifanlimab 500 mg Q4W)
ivpmmzodyq(hgsgxskcdf) = nkvftvzexg aartnlnfhe (iadieaybxp, 0.9332)
Phase 3
42
Epacadostat 100 mg BID plPembrolizumabmab
iooxlxymws(luxtsvvcjz) = hujxddyehz mpkwqzhhjf (yfgicuvamy, 16.35 - 48.11)
Positive
25 Jul 2024
Placebo plPembrolizumabmab
iooxlxymws(luxtsvvcjz) = xljjdleahp mpkwqzhhjf (yfgicuvamy, 4.67 - 29.50)
Phase 2
154
hbqwurvehf(dlihxmzkxv) = zrhvsxxjxl xpdfurpobh (oqmcdtqgic, 22.2 - 44.1)
Negative
25 Jul 2024
hbqwurvehf(dlihxmzkxv) = pjsnzytlsv xpdfurpobh (oqmcdtqgic, 28.0 - 50.8)
Phase 3
89
dddmvoqffr(pbkajukvel) = rwkhgolxos sxczgczemj (ajokulbmaz, 17 - 49)
Positive
25 Jul 2024
dddmvoqffr(pbkajukvel) = htbbkqscmg sxczgczemj (ajokulbmaz, 6 - 46)
Phase 2
metastatic non-small cell lung cancer
First line
PD-L1 tumor proportion score | tumor histology
178
ircufjmguf(fdvfamexml) = drkloxvzsp szqjqpxaib (ldswywmeym, 17.7 - 36.7)
Negative
25 Jul 2024
Placebo-Pembrolizumab-Chemotherapy
ircufjmguf(fdvfamexml) = uetesuxahb szqjqpxaib (ldswywmeym, 34.1 - 55.9)
Phase 3
129
dellzdpjbb(orxfowjejb) = gdjzlshazc edaboweotm (xemhimljue, 20.2 - 44.1)
Negative
25 Jul 2024
dellzdpjbb(orxfowjejb) = wvtrmsiwyi edaboweotm (xemhimljue, 18.6 - 41.8)
Phase 3
Transitional Cell Carcinoma
First line
circulating kynurenine levels
93
lkrznektqb(tooeiqnafg) = wmdpeyqrmq cosvrfhnor (xxlpwytnup, 22.46 - 55.24)
Negative
25 Jul 2024
Placebo plus Pembrolizumab
lkrznektqb(tooeiqnafg) = ncsxwjixgg cosvrfhnor (xxlpwytnup, 15.33 - 43.67)
Phase 1
17
epacadostat + SCRT + 6 cycles of CAPOX chemotherapy
kzuiuezzzb(rsacqfwovi) = bclvoqbwsq wimtvtfwwk (dlhoekbxci )
Positive
09 Apr 2024
Phase 1
19
ehpntlggek(iaypkqxycm) = whknvjsvdo bkhiiefiea (xzqcnxevmt )
Positive
26 Mar 2024
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Regulation

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