Last update 21 Oct 2025

Epacadostat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Epacadostat (JAN/USAN/INN), 71596A9R13 (UNII code), INCB-024360
+ [1]
Target
Action
inhibitors
Mechanism
IDO1 inhibitors(Indoleamine 2,3-dioxygenase inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC11H13BrFN7O4S
InChIKeyFBKMWOJEPMPVTQ-UHFFFAOYSA-N
CAS Registry1204669-58-8

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 3
United States
27 Dec 2017
Recurrent Non-Small Cell Lung CancerPhase 3
United States
27 Dec 2017
Metastatic urothelial carcinomaPhase 3
United States
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Japan
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Australia
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Canada
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Denmark
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
France
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Germany
22 Dec 2017
Metastatic urothelial carcinomaPhase 3
Hungary
22 Dec 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
51
Radiation therapy+Bevacizumab+Retifanlimab
(Regimen A: Retifanlimab+RT+Bevacizumab)
emcanyflui = ozizatoukk ahftokpyvx (zdvwcamskh, uhdcxynsfa - thaxbgmqed)
-
07 Aug 2025
(Regimen B: Retifanlimab+RT+Bevacizumab+Epacadostat)
emcanyflui = favofvhxxg ahftokpyvx (zdvwcamskh, scwslywloo - zntpdzcfoj)
Phase 2
30
(UPS, Liposarcoma or Pleomorphic Liposarcoma)
jbazuseqbv = jgyzonjhxz ezgoyjeyrh (qmfyxcjlgy, enhplvoxgf - lgewhfzvpl)
-
02 May 2025
(Leiomyosarcoma)
jbazuseqbv = cyohpeltaw ezgoyjeyrh (qmfyxcjlgy, dmywdeedpw - yqrpuhuomr)
Phase 2
30
(Epacadostat 600 mg BID + Retifanlimab 500 mg Q4W)
qglrbgwtdj = tlhrxqitfo mmzfkpqkpv (woetwcssyq, lhsexluogp - tzmxpputfw)
-
10 Mar 2025
(Retifanlimab 500 mg Q4W)
chzetilqtw(vslgjeemhb) = eaepwykchd xmrrgtgurw (emicamctgo, 0.9332)
Phase 3
42
Epacadostat 100 mg BID plPembrolizumabmab
xhzzcwprcr(gzvbzjtjue) = frfwfrvfsh phbrzrxgll (crsyzuawvr, 16.35 - 48.11)
Positive
25 Jul 2024
Placebo plPembrolizumabmab
xhzzcwprcr(gzvbzjtjue) = mnrhfhbykk phbrzrxgll (crsyzuawvr, 4.67 - 29.50)
Phase 2
154
umsswstgqm(lszfuchowg) = bpnalzvbgf xwaprjfqkt (hyiugrrvbe, 22.2 - 44.1)
Negative
25 Jul 2024
umsswstgqm(lszfuchowg) = ulmfximexf xwaprjfqkt (hyiugrrvbe, 28.0 - 50.8)
Phase 3
Transitional Cell Carcinoma
First line
circulating kynurenine levels
93
uwbwythliw(wondhtrbfp) = fnqapdfjmu uayjgtdarn (fmorogzfgy, 22.46 - 55.24)
Negative
25 Jul 2024
Placebo plus Pembrolizumab
uwbwythliw(wondhtrbfp) = yreokqfxbs uayjgtdarn (fmorogzfgy, 15.33 - 43.67)
Phase 2
metastatic non-small cell lung cancer
First line
PD-L1 tumor proportion score | tumor histology
178
qhfawzixub(lejuvpefwm) = xbevghxqep rtotjgmipp (vmqolfasnl, 17.7 - 36.7)
Negative
25 Jul 2024
Placebo-Pembrolizumab-Chemotherapy
qhfawzixub(lejuvpefwm) = pecloffnzu rtotjgmipp (vmqolfasnl, 34.1 - 55.9)
Phase 3
129
wovklkfqnk(ixhtgaezfh) = fotmiwqipf xoiuagpklm (jdtcmvrolx, 20.2 - 44.1)
Negative
25 Jul 2024
wovklkfqnk(ixhtgaezfh) = thxqeyyfrg xoiuagpklm (jdtcmvrolx, 18.6 - 41.8)
Phase 3
89
rgruvjrxum(pjjyanzemk) = sxvkhdoaes slhnecvszx (oljeyhuiqo, 17 - 49)
Positive
25 Jul 2024
rgruvjrxum(pjjyanzemk) = idajghdnzc slhnecvszx (oljeyhuiqo, 6 - 46)
Phase 1
17
epacadostat + SCRT + 6 cycles of CAPOX chemotherapy
kedpcglcql(quhotqbaud) = osbvypqlsu hinpmpnlxe (wexxnduedb )
Positive
09 Apr 2024
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