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Last update 22 Jul 2026
AMT-116(Multitude Therapeutics)
Last update 22 Jul 2026
Overview
Basic Info
Drug Type Antibody drug conjugate (ADC) |
Synonyms- |
Target |
Action inhibitors |
Mechanism CD44 inhibitors(CD44 antigen inhibitors), Tubulin inhibitors |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 2/3 |
First Approval Date- |
Regulation- |
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Structure/Sequence
Molecular FormulaC11H22N4O4 |
InChIKeyAGGWFDNPHKLBBV-YUMQZZPRSA-N |
CAS Registry159858-33-0 |
View All Structures (2)
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Related
3
Clinical Trials associated with AMT-116(Multitude Therapeutics)NCT07590531
An Open-label, Multicenter Phase Ib/II Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMT116 in Combination With Ivosimab (AK112) in Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
NCT06782334
Phase 1/2 Study of AMT-116 in Patients with Advanced Solid Tumors
NCT05725291
First-in-Human, Phase 1 Study of AMT-116 in Patients With Advanced Solid Tumors
100 Clinical Results associated with AMT-116(Multitude Therapeutics)
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100 Translational Medicine associated with AMT-116(Multitude Therapeutics)
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100 Patents (Medical) associated with AMT-116(Multitude Therapeutics)
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100 Deals associated with AMT-116(Multitude Therapeutics)
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Advanced Lung Non-Small Cell Carcinoma | Phase 3 | Australia | 28 Aug 2026 | |
| metastatic non-small cell lung cancer | Phase 3 | Australia | 28 Aug 2026 | |
| Advanced Malignant Solid Neoplasm | Phase 2 | China | 24 Apr 2024 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 1/2 | 164 | (all doses) | mxsjtvsnjj(jsogiunjwu) = xpavpkfgte ooyvdiqbfn (gntlddkkil ) View more | Positive | 17 Oct 2025 | ||
(≥3 mg/kg) | mxsjtvsnjj(khoolykyvu) = sxrojxrphk szqzfpsifv (twcjjzjvjo ) View more | ||||||
Phase 1/2 | 102 | ufcllznemf(ohjqckfhea) = xmjoswrcya npumkjgzcg (feqfliumad ) View more | Positive | 17 Oct 2025 | |||
(EGFR wild-type NSCLC) | jhirwlchmm(lyzxvhkbry) = jbmpzlvsbl fbsmqleioj (qrjebfvobq ) View more | ||||||
Phase 1 | 8 | AMT-116 3 mg/kg | paklbpezrw(cljjurqaom) = No DLT events were observed ymfbyzohaw (rzzyayhblm ) View more | Positive | 24 May 2024 |
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Approval
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Biosimilar
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Regulation
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