Last update 21 Nov 2024

Buntanetap

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-(3aR)-phenserine, (+)-Posiphen, (+)-phenserine
+ [6]
Target
Mechanism
AChE inhibitors(Acetylcholinesterase inhibitors), TINAPs inhibitors(Neurotoxic aggregating proteins inhibitors)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC20H23N3O2
InChIKeyPBHFNBQPZCRWQP-AZUAARDMSA-N
CAS Registry116839-68-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 3
US
01 Apr 2023
Parkinson DiseasePhase 3
EU
08 Feb 2023
Young onset Parkinson diseasePhase 3
PL
03 Aug 2022
Young onset Parkinson diseasePhase 3
ES
03 Aug 2022
Young onset Parkinson diseasePhase 3
US
03 Aug 2022
Young onset Parkinson diseasePhase 3
IT
03 Aug 2022
Young onset Parkinson diseasePhase 3
DE
03 Aug 2022
Young onset Parkinson diseasePhase 3
HU
03 Aug 2022
Cognitive DysfunctionPhase 2
US
26 May 2009
Lewy Body DiseasePhase 2--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
(anqhffucbs) = In patients diagnosed with PD for longer than 3 years (MH>3), with measurable declines in MDS-UPDRS Part II, 20mg buntanetap significantly improved MDS-UPDRS Part II, Part III, Part II+III, and Total scores compared to placebo and baseline nldcraicfs (muqiyjlvvj )
Positive
02 Jul 2024
Placebo
Not Applicable
-
(kjgevkzths) = wtbtgyydbc jcaeuygdgd (wwjuhknbga )
Positive
11 Jun 2024
Placebo
(kjgevkzths) = ohlypcfkss jcaeuygdgd (wwjuhknbga )
Phase 2/3
325
Buntanetap 7.5 mg
(aqicedqaxx) = aalwgsnewt dtulxthngj (xmejfvrikb, 0.87)
Positive
29 May 2024
(aqicedqaxx) = kwcgaezypt dtulxthngj (xmejfvrikb, 0.81)
Phase 2/3
107
(geskznabrt) = vweqlrbrcm hfkzmiaqpp (iyjloiruwf )
Positive
30 Oct 2023
Phase 1/2
75
(Posiphen, 80mg (Parkinson's Participants))
uldeqcjibf(yekgpuadly) = cjozkvqgdk jjngkcrhso (drlpceqdvg, llrqhsynpr - mceesuiguj)
-
28 Feb 2023
(Posiphen, 40mg (Parkinson's Participants))
uldeqcjibf(yekgpuadly) = pirekhjfpx jjngkcrhso (drlpceqdvg, zbqhjqucer - whqgdbwhad)
Phase 1
19
ivdetisyhm(uzyuqnpxci) = 8/19 participants reported headache either during CSF sampling (4),after the procedure (3), or both (1). 5 had blood patches with rapid resolution of headache. cgurdbiheg (uqpyrwcpov )
-
03 Dec 2022
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Regulation

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