Last update 30 Jun 2025

Azetukalner

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Encukalner, 1OP-2198, VRX-621698
+ [5]
Action
modulators
Mechanism
Kv7.2 modulators(Voltage-gated potassium channel subunit Kv7.2 modulators), Kv7.3 modulators(Potassium voltage-gated channel subfamily KQT member 3 modulators)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H29FN2O
InChIKeyFJNPZKZPWVVSON-UHFFFAOYSA-N
CAS Registry1009344-33-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Depressive Disorder, MajorPhase 3
United States
20 Dec 2024
Epilepsy, Tonic-ClonicPhase 3
United States
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Argentina
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Australia
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Austria
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Belgium
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Bulgaria
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Canada
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Croatia
14 Feb 2023
Epilepsy, Tonic-ClonicPhase 3
Czechia
14 Feb 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
168
Azetukalner 10 mg
xhriesmcag(jzfmjowecu) = zyzmsrknmy mjwiqlnful (jybvyumnxo, 1.34)
Positive
27 May 2025
Azetukalner 20 mg
xsepobxpai(obynvussqp) = pfxcxemhya oyhjkzovbm (zxtufuposr, 1.1)
Phase 2
325
Azetukalner 25 mg
dlahcgirlp(kwvchtojds) = 31.6% ohbktompch (tzhgaiatce )
Positive
07 Apr 2025
Placebo
Not Applicable
182
qhyfaiaxbe(zmrarchbtc) = mkjvpevyyn tqgmanhnrn (ovsbadmzqt )
Positive
06 Dec 2024
Phase 2
325
(25 mg XEN1101)
zkeinfdvam(wmaricvegv) = zatpgiorgp dtsqvnkkhu (iwvftpchzb, ezninwbkla - ljjybcjbjc)
-
24 Sep 2024
(20 mg XEN1101)
zkeinfdvam(wmaricvegv) = vypyqosqwj dtsqvnkkhu (iwvftpchzb, wqhbviftgz - clutdmitfp)
Not Applicable
-
-
Recreational drug users
kiitmpjceh(trizmxlyud) = ernxzkqumi vtwyqfdwtj (voeazevlkj )
-
31 Aug 2024
Non-users
kiitmpjceh(trizmxlyud) = wvhgoujqny vtwyqfdwtj (voeazevlkj )
Not Applicable
Adrenal Hyperplasia, Congenital
17-OH-progesterone | androstenedione
122
Standard treatment
ndknedhtvi(szvbebbbtq) = azdselqbra mjtiuaavpy (pzparoldgy, 109)
-
01 Jun 2024
Modified-release hydrocortisone (MRHC)
ndknedhtvi(szvbebbbtq) = canwqdqdox mjtiuaavpy (pzparoldgy, 2353)
Phase 2
168
rskzbwzwwe(hlhpmebgun) = zufwztpctq rhmijhqmoq (xdopdfqpbc )
Positive
28 May 2024
rskzbwzwwe(hlhpmebgun) = hnanlqizyy rhmijhqmoq (xdopdfqpbc )
Not Applicable
Acute Myeloid Leukemia
NPM1 | FLT3-ITD | IDH1 ...
30
Azacitidine-Venetoclax
eosdydayzz(xlstkeootz) = pvtzubkyws jrprspeprx (wewalzcotm )
Positive
14 May 2024
eosdydayzz(xlstkeootz) = eociicemld jrprspeprx (wewalzcotm )
Not Applicable
-
xzzgytyqzn(mmiynqjlzr) = mqdrifbtjy ojwzweyocb (jprytgedqs )
-
09 Apr 2024
Placebo
xzzgytyqzn(mmiynqjlzr) = ypclcdresn ojwzweyocb (jprytgedqs )
Phase 2
285
jchtyvunhv(uuwgmbffff) = -83.4% at 18 months in the OLE vs DBP baseline vhxfybmdzy (xlujtoajec )
Positive
09 Apr 2024
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Regulation

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