Last update 12 Apr 2025

PM-1016

Overview

Basic Info

Drug Type
Gene therapy
Synonyms
PM 1016, PM1016
Target
IL-2
Action
inhibitors, stimulants
Mechanism
IL-2 inhibitors(Interleukin-2 inhibitors), Cell death stimulants
Therapeutic Areas
NeoplasmsDigestive System Disorders
Active Indication
Hepatocellular Carcinoma
Inactive Indication
Advanced Malignant Solid Neoplasm
Originator Organization
Biotheus, Inc.Biotheus, Inc.Startup
Active Organization
TILT Biotherapeutics OyTILT Biotherapeutics Oy
Inactive Organization
Biotheus, Inc.Biotheus, Inc.StartupGenIbet Biopharmaceuticals SAGenIbet Biopharmaceuticals SA
Drug Highest PhaseIND Approval
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with PM-1016
CTR20222200
/ TerminatedPhase 1
评价PM8002注射液联合PM1016注射液二线治疗晚期肝细胞癌受试者的初步疗效及安全性的Ib期临床试验
[Translation] A phase Ib clinical trial to evaluate the preliminary efficacy and safety of PM8002 injection combined with PM1016 injection as a second-line treatment for subjects with advanced hepatocellular carcinoma
CTR20210764
/ TerminatedPhase 1/2
评价编码 TNF-α 和 IL-2 的溶瘤腺病毒 PM1016 在晚期恶性实体瘤受试者中的耐受性、安全性及初步疗效的 I 期临床试验及在晚期恶性实体瘤中考察初步疗效的 IIa 期临床试验
[Translation] A Phase I clinical trial to evaluate the tolerability, safety and preliminary efficacy of oncolytic adenovirus PM1016 encoding TNF-α and IL-2 in subjects with advanced malignant solid tumors and a Phase IIa clinical trial to investigate preliminary efficacy in subjects with advanced malignant solid tumors
100 Clinical Results associated with PM-1016
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100 Translational Medicine associated with PM-1016
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100 Patents (Medical) associated with PM-1016
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100 Deals associated with PM-1016
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
China
GenIbet Biopharmaceuticals SAGenIbet Biopharmaceuticals SA
23 Jun 2021
Advanced Malignant Solid NeoplasmPhase 2
China
Biotheus, Inc.Biotheus, Inc.Startup
23 Jun 2021
Advanced Malignant Solid NeoplasmPhase 2
China
TILT Biotherapeutics OyTILT Biotherapeutics Oy
23 Jun 2021
Hepatocellular CarcinomaIND Approval
China
TILT Biotherapeutics OyTILT Biotherapeutics Oy
18 Aug 2022
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Clinical Result

Indication
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Approval

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Regulation

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