Delving into the Latest Updates on COVID19 Oral Vaccine Consisting of Bacillus Subtilis Spores(DreamTec Research) with Synapse

Overview

Basic Info

Drug Type

Prophylactic vaccine, Probiotics

Synonyms-

Target-

Action

stimulants, modulators

Mechanism

Bacteria replacements, Immunostimulants, Microbiome modulators

Therapeutic Areas

Infectious DiseasesRespiratory Diseases

Active Indication-

Inactive Indication

COVID-19

Originator Organization

DreamTec Research Limited

Active Organization-

Inactive Organization

DreamTec Research Limited

License Organization-

Drug Highest PhasePendingClinical

First Approval Date-

Regulation-

This study aimed to investigate the effects of dietary Bacillus subtilis (B. subtilis) supplementation in pigs on the meat color and oxidative stability of the meat under high‑oxygen packaging. The results showed B. subtilis increased redness (a*) (P < 0.05), accompanied by inhibiting the formation of metmyoglobin (MetMb) of pork, and maintained better meat color during storage. Compared to the control group, dietary B. subtilis supplementation increased the R630/580 value, metmyoglobin-reducing activity (MRA) and the oxygen consumption rate (OCR) of pork (P < 0.05), and the pork had better meat color stability. B. subtilis supplementation also upregulated the expression of Nrf2 and downstream antioxidant enzyme genes (SOD, CAT, and GSH-Px) in the Nrf2-Keap1 signaling pathway and downregulated the expression of the Keap1 (P < 0.05). The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and catalase (CAT) in longissimus thoracis et lumborum (LTL) muscle were increased by B. subtilis while the levels of lipid and protein oxidation were decreased (P < 0.05). All results confirmed that dietary B. subtilis supplementation could effectively maintain the meat color and delay the oxidation of chilled pork compared to the control.

05 Mar 2025·Journal of Agricultural and Food Chemistry

Probiotic–Enzyme Synergy Regulates Fermentation of Distiller’s Grains by Modifying Microbiome Structures and Symbiotic Relationships

Article

Author: Zhang, Jin ; Wang, Changtong ; Yu, Hulong ; Huang, Wenming ; Yang, Liandi ; Zuo, Fuyuan ; Chen, Zhihua ; Chen, Yanqing

The high fiber content and low rumen digestibility prevent the efficient use of distiller's grains (DGS) in ruminant feeds. This study investigated the effects of probiotics (Lactiplantibacillus plantarum and Bacillus subtilis) and enzymes (β-glucanase, xylanase, β-mannanase, and cellulase) on DGS nutrient content, ruminal degradability, and microbial communities under anaerobic storage for 30 days. Groups included control (C), probiotics (B), enzymes (E), and their mixture (EB). As compared to groups C, B, and E, neutral detergent fiber (NDF), acid detergent fiber (ADF), hemicellulose, and cellulose contents were significantly decreased and the ruminal degradability of NDF and ADF at 48 h was significantly increased in group EB (p < 0.05). Enzyme activities significantly affected bacterial abundance, and the contents of these enzymes were negatively correlated with the content of fibrous components. The abundances of Bacillus and Rummeliibacillus were negatively correlated with fiber content but positively correlated with the activities of these enzymes. The symbiotic relationship between Bacillus and Anaerocolumna in the EB group sustained the synergistic effects of probiotics and enzymes. Co-fermentation of probiotics and enzyme additives enhanced the nutritional value of DGS, which was associated not only with probiotic-enzyme synergy but also variations in dominant microbes and microbiome commensal relationships.

03 Feb 2025·Journal of Applied Microbiology

Bacillus subtilis MZ-01 alleviates diarrhea caused by ETEC K88 by reducing inflammation and promoting intestinal health

Article

Author: Bai, Guangdong ; Qin, Jianwei ; Zhang, Yue ; Liu, Yang ; Cao, Mingming ; Shi, Baoming

AbstractAimsThe purpose of this study was to investigate the effects of Bacillus subtilis supplementation on the health of weaned piglets and whether B. subtilis supplementation can reduce the damage of piglets induced by ETEC K88.Methods and resultsThe experiment was designed with a 2 × 2 factorial arrangement, comprising the control group, B. subtilis (PRO) group, Escherichia coli K88 (ETEC) group, and B. subtilis + ETEC (PRO + ETEC) group. Regardless of the presence of ETEC, the addition of PRO increased the piglets’ final body weight, average daily gain, and daily feed intake. Additionally, PRO primarily achieves a reduction in heat-stable enterotoxin (ST) levels, suppresses the expression of NF-κB, TLR4, and MyD88 mRNA in the jejunum and ileum, lowers pro-inflammatory factors in the blood and small intestine, enhances the expression of tight junction proteins in the small intestine, improves the composition of the colonic microbiota, increases colonic short-chain fatty acid contents, thereby alleviating diarrhea and mitigating bodily damage caused by ETEC K88 infection.ConclusionThe addition of B. subtilis MZ-01 alleviated ETEC K88-induced piglet diarrhea by reducing ST levels, decreasing pro-inflammatory factors in the blood and intestine, and enhancing the intestinal barrier and tight junction proteins.

100 Deals associated with COVID19 Oral Vaccine Consisting of Bacillus Subtilis Spores(DreamTec Research)

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05057923 (CTgov)	Not Applicable	COVID-19	9	Bacillus subtilis	sskolgdiva(lozwgsguha) = ztgdulaobv rvrqzrcwsm (xfiehwwnsu, fzivskruda - tcjjztkfsa) View more	-	23 Dec 2021