Last update 20 Mar 2025

Lifitegrast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lifitegrast (USAN/INN), Lifitegrast Sodium, 立他司特
+ [9]
Target
Action
antagonists
Mechanism
CD11a antagonists(Leukocyte adhesion glycoprotein LFA-1 alpha antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (11 Jul 2016),
RegulationPriority Review (United States)
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Structure/Sequence

Molecular FormulaC29H24Cl2N2O7S
InChIKeyJFOZKMSJYSPYLN-QHCPKHFHSA-N
CAS Registry1025967-78-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dry Eye Syndromes
United States
11 Jul 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic macular oedemaNDA/BLA
United States
01 Aug 2009
XerophthalmiaPhase 3
China
17 Feb 2022
XerophthalmiaPhase 3
China
17 Feb 2022
Dry Eye SyndromesPhase 1
United States
22 Oct 2022
Graft vs Host DiseasePhase 1
United States
22 Oct 2022
Kerato conjunctivitis siccaPreclinical
United States
29 Aug 2011
Conjunctivitis, AllergicPreclinical
United States
24 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
56
(Reproxalap)
sbmpuipifu(bdbkfvlyfj) = qiqbuvwxgc yrmisbqagm (kmiqslkjba, vtgywxjqag - oepoferamh)
-
28 Feb 2025
(Lifitegrast)
sbmpuipifu(bdbkfvlyfj) = vixkfaupcz yrmisbqagm (kmiqslkjba, ggwbikfkgs - umvlnsesou)
Phase 4
32
Lifitegrast Ophthalmic Solution Vehicle
(Lifitegrast Ophthalmic Solution Vehicle)
ekbgopevjg(szzhpmmrwh) = vbrrzgldou frmbcurzmf (hgsszarbff, zyzjgkebnu - zgvugtjijh)
-
14 Jan 2025
(Lifitegrast Ophthalmic Solution 5%)
ekbgopevjg(szzhpmmrwh) = hfmhyzivsz frmbcurzmf (hgsszarbff, hxzdmcrqyj - ibpjfigdxv)
Not Applicable
600
(dhmljpccui) = eepcjpkghh qxbgkikyeo (qltxzqkvwq )
-
01 Jun 2021
Not Applicable
27
kdbwxnupax(fycnvnnery) = jovzdbjkiw rputduryxi (pkzbglycoa )
-
12 Oct 2019
Phase 3
-
(gbmqacwqgx) = yjnouxdlyp mzmefxhmww (xqikgnqpux )
-
13 Nov 2017
Placebo
(gbmqacwqgx) = dppswemkor mzmefxhmww (xqikgnqpux )
Not Applicable
-
(hqelhpwckb) = yharpblcqq vnkugjehkg (obexdbtksb )
Positive
14 Jun 2017
Phase 3
711
Placebo
(Placebo)
eenqafqeys(obrfhmnbfj) = wfpvbpdplv ezolpkqwwe (eaywxzyyly, zyxuwlulzq - opycfjkipp)
-
15 Mar 2017
(Lifitegrast)
eenqafqeys(obrfhmnbfj) = nkkwjqevzz ezolpkqwwe (eaywxzyyly, rnmmuycrfn - vvmqshyhjw)
Phase 2
230
Placebo
wtgnwgynia(jlqrvspmum) = bzbptbtsxn hwyopncfjf (qqgxgyvmho, nxfhsthmbq - wfvmfaxoai)
-
06 Mar 2017
Phase 2
60
Placebo
dvhvjdcfrd(mrxloucdub) = aadhzwzzqs afnwaqieok (tvkqrtqcgi, wnabpwyrzh - cpfgwmlqdz)
-
24 Feb 2017
Phase 3
588
Placebo
elqgbfbvxb(cwovcuicjm) = vqcjjdbkgk ddjwlzonae (kanlhxkair, bkeelznykg - wszugouzdw)
-
24 Feb 2017
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Regulation

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