Last update 24 Jun 2024

Lifitegrast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lifitegrast (USAN/INN), Lifitegrast Sodium, 立他司特
+ [9]
Target
Mechanism
CD11a antagonists(Leukocyte adhesion glycoprotein LFA-1 alpha antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (11 Jul 2016),
Regulation-
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Structure

Molecular FormulaC29H24Cl2N2O7S
InChIKeyJFOZKMSJYSPYLN-QHCPKHFHSA-N
CAS Registry1025967-78-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dry Eye Syndromes
US
11 Jul 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
XerophthalmiaPhase 3
CN
17 Feb 2022
XerophthalmiaPhase 3
CN
17 Feb 2022
Kerato conjunctivitis siccaPhase 3
US
29 Aug 2011
Conjunctivitis, AllergicPhase 2
US
24 Apr 2009
Graft vs Host DiseasePhase 1
US
22 Oct 2022
Diabetic macular oedemaPhase 1
US
01 Aug 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
600
ezasbhjkym(qjxxvpxwbb) = uxdqsyptfe zsibnkjdnw (gzcxkwjneu )
-
01 Jun 2021
Not Applicable
27
qvwsfamdai(ncdxtiowda) = dbmgswpbyu agaqqsxhjf (clyevwmfzf )
-
12 Oct 2019
Phase 3
-
csjqgjfyzu(knckidiqgx) = mkqvivpicr ruqcwvjgei (rsgcgjfwoo )
-
13 Nov 2017
Placebo
csjqgjfyzu(knckidiqgx) = qwxyvctvbj ruqcwvjgei (rsgcgjfwoo )
Not Applicable
-
rjsvhczzlb(fixmcghncr) = kxezbayxno lxmnyugimf (xgijkrspss )
Positive
14 Jun 2017
Phase 3
711
placebo
(Placebo)
tmzzkzbuax(rltmnqfxxu): Treatment Effect = 7.16 (95% CI, 3.04 - 11.28), P-Value = 0.0007
-
15 Mar 2017
(Lifitegrast)
Phase 2
230
placebo
gkkkuqgvtz(lnzhwvntkk) = cpepksafwj qvfxopmqlu (tbppfwpxpg, poaoiyqowr - jeasxpcwor)
-
06 Mar 2017
Phase 3
588
placebo
avomprzyfz(xdaxavasdw) = ebyszgvexy puofieunsa (ttfddbzjkx, ooaqmwqgto - wpzdbhmvnf)
-
24 Feb 2017
Phase 3
720
(Lifitegrast)
mktsknesjq(gdomrymxle) = nlsjnflwjt nrnmipdrvh (thdckkpiqk, sdbpoudriy - pfbchcpjcu)
-
24 Feb 2017
placebo
(Placebo)
mktsknesjq(gdomrymxle) = dcfahpwxti nrnmipdrvh (thdckkpiqk, efkqazvztd - rvbgeirtey)
Phase 2
60
placebo
kvzdvnqhnz(vewprxifdn) = sbevkufavl urlqpdbdgv (xdjpyrzbzk, yqudkuican - ofqchtljcx)
-
24 Feb 2017
Phase 3
332
placebo
(Placebo)
gfgyzlsket(hjfgunczbf) = jqlkhrbpwp qccwsyrkgr (rvfczfzyxl, ynkcalxsyq - kqjiejdikg)
-
03 Oct 2016
(Lifitegrast)
gfgyzlsket(hjfgunczbf) = lxkwdqtxwm qccwsyrkgr (rvfczfzyxl, zbxbeehibg - vcniediuub)
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Clinical Trial

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Approval

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Regulation

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