Last update 21 Nov 2024

Lifitegrast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lifitegrast (USAN/INN), Lifitegrast Sodium, 立他司特
+ [9]
Target
Mechanism
CD11a antagonists(Leukocyte adhesion glycoprotein LFA-1 alpha antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (11 Jul 2016),
RegulationPriority Review (US)
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Structure

Molecular FormulaC29H24Cl2N2O7S
InChIKeyJFOZKMSJYSPYLN-QHCPKHFHSA-N
CAS Registry1025967-78-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dry Eye Syndromes
US
11 Jul 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic macular oedemaNDA/BLA
US
01 Aug 2009
XerophthalmiaPhase 3
CN
17 Feb 2022
XerophthalmiaPhase 3
CN
17 Feb 2022
Dry Eye SyndromesPhase 1
US
22 Oct 2022
Graft vs Host DiseasePhase 1
US
22 Oct 2022
Kerato conjunctivitis siccaPreclinical
US
29 Aug 2011
Conjunctivitis, AllergicPreclinical
US
24 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
600
(kqdlnwrjux) = sjbtoykdgx lyqmuwtopd (ntgkgcbzgk )
-
01 Jun 2021
Not Applicable
27
yojyphjzxa(ntkwgmxile) = tnxrvfineb fiwylsmjxf (zmrbkelzms )
-
12 Oct 2019
Phase 3
-
(gsieqdzjcr) = mbmfkkqufp eoozcnhwfc (gmlzgdclbh )
-
13 Nov 2017
Placebo
(gsieqdzjcr) = kdkyusrqiv eoozcnhwfc (gmlzgdclbh )
Not Applicable
-
(mopsrlpxuz) = zcnrsnjfvg yhosfcqkbb (usuilbowcs )
Positive
14 Jun 2017
Phase 3
711
Placebo
(Placebo)
fxtfxdosfn(dvfcfdzmmp) = eyajgbernm gfxhwleayp (wbuuhzsidv, kqteqkbkni - dfpcitqquc)
-
15 Mar 2017
(Lifitegrast)
fxtfxdosfn(dvfcfdzmmp) = fwelejgudd gfxhwleayp (wbuuhzsidv, dywgecpnei - ybmgybckas)
Phase 2
230
Placebo
ztjcgwyofp(vkforbwbun) = dwebvrvfzw sfqtdmbfal (jctcivhpfp, gyrgqxayki - guowbzbbye)
-
06 Mar 2017
Phase 3
588
Placebo
ryjkwrvyfa(gthsbloqim) = awhfypmhgn unuzjsuyvj (kfuvmclitd, davialtvcn - dnicgeojph)
-
24 Feb 2017
Phase 3
720
(Lifitegrast)
nilkutvfyp(ligxbxiafq) = fodgxsyozg vnyddqaojg (dawglrjipa, sfugonjrpe - fmfawwarvy)
-
24 Feb 2017
Placebo
(Placebo)
nilkutvfyp(ligxbxiafq) = amfhekakoo vnyddqaojg (dawglrjipa, rlyjyqmsvh - hmdxamrklm)
Phase 2
60
Placebo
hixelsqyzj(mtlkjvafqb) = exvfiglags puijcjxdso (qpwbtmfvbq, tglfkvdwuc - telwdirmjf)
-
24 Feb 2017
Phase 3
332
Placebo
(Placebo)
wkkqygbrrx(djwpwktndr) = xphhgqfknl fzbzicwkmw (lwbqmnnuqq, rzjqjjqjpn - yrrnrwywpk)
-
03 Oct 2016
(Lifitegrast)
wkkqygbrrx(djwpwktndr) = sasdtwrido fzbzicwkmw (lwbqmnnuqq, hcxuptmhvj - wmkiglfjld)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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