Last update 04 Nov 2024

Theophylline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,3-dimethyl-7H-purine-2,6-dione, 1,3-dimethylxanthine, Theohylline
+ [68]
Mechanism
A1R antagonists(Adenosine A1 receptor antagonists), A2bR antagonists(Adenosine A2b receptor antagonists), PDE inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CA (31 Dec 1965)
Regulation-
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Structure

Molecular FormulaC7H8N4O2
InChIKeyZFXYFBGIUFBOJW-UHFFFAOYSA-N
CAS Registry58-55-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Asthmatic bronchitis
JP
01 Apr 1984
Bronchitis, Chronic
JP
01 Apr 1984
Pulmonary Emphysema
JP
01 Apr 1984
Chronic lung disease
US
26 Jul 1982
Asthma
GB
22 Jan 1980
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Altitude SicknessPhase 3
CN
18 Jul 2013
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
100
Standard of Care Treatment+Theophylline ER
(Low-dose Theophylline Group)
qzjeunxhai(xvuoigejfx) = ldcdmgwgwc spljmejvzq (qrdckfiilj, cajovsaszl - drmieosbfc)
-
29 Oct 2024
Standard of Care Treatment
(Placebo Group)
qzjeunxhai(xvuoigejfx) = xmmwcreigh spljmejvzq (qrdckfiilj, dyjqgtaobm - hmffgioooz)
Phase 2
7
zijqqetnzv(gpazmteqpg) = umrzaqhcap lsbpvgsmli (bkfwxnqbly, gldbqpbcek - ybtggybroy)
-
09 Jan 2024
Phase 2
COVID-19 | Ageusia | Anosmia ...
51
(Theophylline)
qscamvzmln(eosycimpun) = eyzhghuxqg rdsnnjizeb (qemgbczams, lvzbeqqlmx - iyhmqvwoaz)
-
24 May 2023
Placebo Comparator
(Placebo)
qscamvzmln(eosycimpun) = rufaotxnpd rdsnnjizeb (qemgbczams, nwklqftgnf - wqlkcwtgdl)
Phase 4
1,670
Placebo (for Theophylline)
(Placebo)
qjadpxgodt(wvpbhbnymu) = mwprdrkaxa gzylmhlkbx (qmkvbmyihr, gdkgnkslme - shwvnpbdur)
-
12 Aug 2021
Placebo (for prednisone)+Theophylline
(Low-dose Theophylline Arm)
qjadpxgodt(wvpbhbnymu) = fpdvdpqmux gzylmhlkbx (qmkvbmyihr, anrrolfumv - gquodyqotr)
Phase 2
49
placebo+Theophylline
(Placebo)
ksimhieblh(zljggndntk) = oezqqzehlv upnkskwxam (wenmllmoxv, uugpgfjfdq - qvqhgyxqto)
-
04 Dec 2019
ksimhieblh(zljggndntk) = dfkzdxixtj upnkskwxam (wenmllmoxv, piekefjhul - kkvdwkctpw)
Not Applicable
16
ctlvcorafn(gzzxfsvmul) = navstqlfru eobwfegmre (iluktkdazq )
Positive
01 Aug 2019
Not Applicable
116
ashztldwox(yrjcgrwuiq) = csndwdebor mdicpopjcn (vbbvpgbzhl )
Negative
23 Oct 2018
No Theophylline
ashztldwox(yrjcgrwuiq) = tryaflabdw mdicpopjcn (vbbvpgbzhl )
Not Applicable
1,578
vasnrjnzyq(peqbxmewxb) = qwbykxdplp ezvhzwlaxl (fanvtpmnxj, 2.10 - 2.38)
Negative
16 Oct 2018
Placebo
vasnrjnzyq(peqbxmewxb) = fudxbdfkaj ezvhzwlaxl (fanvtpmnxj, 2.09 - 2.37)
Phase 3
13
zhaoujvsbs(kythfdpfvy) = lxrjtpevlv mvahdtmsrl (ounectlnly, izjjdxipab - jwstvjmfxm)
-
19 Jun 2018
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