Last update 07 Jun 2025

Alvespimycin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin, 17-dimethylaminoethylamino-17-demethoxy-geldanamycin, Alvespimycin
+ [9]
Target
Action
inhibitors
Mechanism
HSP90 inhibitors(Heat shock 90kDa proteins inhibitors)
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC32H49ClN4O8
InChIKeyDFSYBWLNYPEFJK-IHLRWNDRSA-N
CAS Registry467214-21-7

External Link

KEGGWikiATCDrug Bank
D06554--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HER2 Positive Breast CancerPhase 2-01 Apr 2008
B-Cell Prolymphocytic LeukemiaPhase 1
United States
01 May 2010
Chronic lymphocytic leukaemia refractoryPhase 1
United States
01 May 2010
Recurrent Chronic Lymphoid LeukemiaPhase 1
United States
01 May 2010
Metastatic human epidermal growth factor 2 positive carcinoma of breastPhase 1
United States
01 Jan 2006
Adult T-Cell Leukemia-LymphomaPhase 1
United States
01 Jul 2004
Anaplastic Large-Cell LymphomaPhase 1
United States
01 Jul 2004
Breast cancer recurrentPhase 1
United States
01 Jul 2004
Burkitt LymphomaPhase 1
United States
01 Jul 2004
Diffuse Large B-Cell LymphomaPhase 1
United States
01 Jul 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
yrlokfjqsp(uveqiyiitu) = vuotudrsxp pfmthqnzps (sxajlqbwjz )
-
20 May 2009
Phase 1
10
gfnvcqevgz(cmcqalgfmf) = fhojmrdile apymnopzqg (lkemirfwis )
-
20 Jun 2007
Phase 1
23
efynpvxrav(ecppzgkewl) = ccptknuqsz fgsyjglmut (fhihlsmpkq )
-
20 Jun 2007
Phase 1
13
egpqfcmwqz(jsvnimvlcd) = bushewvtyl ytdfghoecg (gdftdmvrko )
-
20 Jun 2006
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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