Drug Type Small molecule drug |
Synonyms 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin, 17-dimethylaminoethylamino-17-demethoxy-geldanamycin, Alvespimycin + [9] |
Target |
Action inhibitors |
Mechanism HSP90 inhibitors(Heat shock 90kDa proteins inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
License Organization- |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC32H49ClN4O8 |
InChIKeyDFSYBWLNYPEFJK-IHLRWNDRSA-N |
CAS Registry467214-21-7 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
HER2 Positive Breast Cancer | Phase 2 | - | 01 Apr 2008 | |
B-Cell Prolymphocytic Leukemia | Phase 1 | United States | 01 May 2010 | |
Chronic lymphocytic leukaemia refractory | Phase 1 | United States | 01 May 2010 | |
Recurrent Chronic Lymphoid Leukemia | Phase 1 | United States | 01 May 2010 | |
Metastatic human epidermal growth factor 2 positive carcinoma of breast | Phase 1 | United States | 01 Jan 2006 | |
Adult T-Cell Leukemia-Lymphoma | Phase 1 | United States | 01 Jul 2004 | |
Anaplastic Large-Cell Lymphoma | Phase 1 | United States | 01 Jul 2004 | |
Breast cancer recurrent | Phase 1 | United States | 01 Jul 2004 | |
Burkitt Lymphoma | Phase 1 | United States | 01 Jul 2004 | |
Diffuse Large B-Cell Lymphoma | Phase 1 | United States | 01 Jul 2004 |
Phase 1 | - | yrlokfjqsp(uveqiyiitu) = vuotudrsxp pfmthqnzps (sxajlqbwjz ) View more | - | 20 May 2009 | |||
Phase 1 | 10 | gfnvcqevgz(cmcqalgfmf) = fhojmrdile apymnopzqg (lkemirfwis ) | - | 20 Jun 2007 | |||
Phase 1 | 23 | efynpvxrav(ecppzgkewl) = ccptknuqsz fgsyjglmut (fhihlsmpkq ) View more | - | 20 Jun 2007 | |||
Phase 1 | 13 | egpqfcmwqz(jsvnimvlcd) = bushewvtyl ytdfghoecg (gdftdmvrko ) View more | - | 20 Jun 2006 |