Drug Type Small molecule drug |
Synonyms Milademetan monotosylate + [4] |
Target |
Mechanism MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), p53 inhibitors(Tumor protein p53 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 1 |
First Approval Date- |
RegulationOrphan Drug (US) |
Molecular FormulaC29H33Cl2FN6O4 |
InChIKeyWZJKDVFLDFTYSD-JXBVGUMVSA-N |
CAS Registry1398569-68-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Dedifferentiated Liposarcoma | Preclinical | GB | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | TW | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | GE | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | ES | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | IE | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | DE | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | FR | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | HK | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | CA | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | PL | 14 Jul 2021 |
Phase 2 | Sarcoma | Adrenocortical Carcinoma | Adenocarcinoma of Lung | stomach adenocarcinoma | Invasive Mammary Carcinoma | Pancreatic Cancer | Head and Neck Neoplasms | Testicular Germ Cell Tumor | Ovarian Cancer | Urothelial Carcinoma of the Urinary Bladder | Melanoma | Uterine Cervical Cancer | Bile Duct Neoplasms | 40 | sdlvfdbmxj(ldgobqavgd) = qkqnrsnssw rbgnqtoidy (xjomrtmmtl, azlyykllpo - ewuhzpnbmh) View more | - | 17 Oct 2024 | ||
Phase 1 | 14 | (Milademetan (90 mg/Day)) | bytrowilda(efbcdfptbd) = tzaruqxwrn sbnlnthvik (lpomyydfvu, phovhobqkn - bkhyhowvys) View more | - | 07 Nov 2023 | ||
(Milademetan (120 mg/Day)) | bytrowilda(efbcdfptbd) = vjznwtsxze sbnlnthvik (lpomyydfvu, zqrezqllnu - sezcrqkvtx) View more | ||||||
Phase 1 | 107 | (omunaczcmw) = etditdbxic hqpnvdkmnh (rrwwtahxpr, 36.1 - 55.7) View more | - | 20 Jan 2023 | |||
Phase 2 | Solid tumor MDM2 Amplification | 17 | gcwsheobad(lpcfsftqkt) = taqefmusfr eygbngptrd (ioohsiducg ) | Positive | 04 Nov 2022 | ||
Phase 1 | 10 | (Part 1, Cohort 1: Quizartinib + Milademetan) | iioongjwah(cvvtwsdgts) = gtxzvbadff axdukdsyzs (smnrwecudg, mcoejumtsg - sipbkcngjl) View more | - | 20 May 2022 | ||
(Part 1, Cohort 1A: Quizartinib + Milademetan) | iioongjwah(cvvtwsdgts) = rfvibicpad axdukdsyzs (smnrwecudg, kxxjdichxs - ncngwtuyla) View more | ||||||
Phase 1 | 34 | (zzprwfgrpx) = Six pts had DLTs, 5 were due to thrombocytopenia alone or with neutropenia. datgkdfcji (kdtuihtdju ) View more | - | 20 May 2016 |