Last update 12 Dec 2024

Milademetan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Milademetan monotosylate, DS-3032, DS3032B
+ [4]
Mechanism
MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), p53 inhibitors(Tumor protein p53 inhibitors)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhasePhase 1
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC29H33Cl2FN6O4
InChIKeyWZJKDVFLDFTYSD-JXBVGUMVSA-N
CAS Registry1398569-68-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dedifferentiated LiposarcomaPhase 3
US
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
AT
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
BE
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
CA
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
FR
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
GE
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
DE
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
HK
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
IE
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
IT
14 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
14
(Milademetan (90 mg/Day))
phrdobjpil(rbhivcyaip) = ziuiricncn bumfnwmowp (wxdmboasgq, buzrglijan - blvkrlqjop)
-
07 Nov 2023
(Milademetan (120 mg/Day))
phrdobjpil(rbhivcyaip) = zdmtqkhqlb bumfnwmowp (wxdmboasgq, gnkmbomurf - wovhwzmkqw)
Phase 1
107
(ariwrmdmrf) = uqxyroyhxc siyqlwqkju (fkclhhknzt, 36.1 - 55.7)
-
20 Jan 2023
Phase 1
10
(Part 1, Cohort 1: Quizartinib + Milademetan)
ukydhgffbs(bgoyjdkkpp) = yxrsixlmet htbwgzwcqc (vthrgstvxk, sodrpzjapx - bzgyomiagg)
-
20 May 2022
(Part 1, Cohort 1A: Quizartinib + Milademetan)
ukydhgffbs(bgoyjdkkpp) = nosnxknfbi htbwgzwcqc (vthrgstvxk, wabdpyetym - sxldeemmvg)
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Approval

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Regulation

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