Last update 01 Nov 2024

PXS-4728

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [4]
Mechanism
MAO-B inhibitors(Monoamine oxidase B inhibitors), VAP-1 inhibitors(Amine oxidase, copper containing inhibitors)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC15H21FN2O2
InChIKeyOWNSXNXYELKDSO-DHZHZOJOSA-N
CAS Registry1478364-40-7
View All Structures (2)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nonalcoholic SteatohepatitisPhase 3
ES
06 Jun 2017
Nonalcoholic SteatohepatitisPhase 3
IE
06 Jun 2017
Nonalcoholic SteatohepatitisPhase 3
DE
06 Jun 2017
Parkinson DiseasePhase 2--
Nonalcoholic SteatohepatitisPreclinical
FR
06 Jun 2017
Nonalcoholic SteatohepatitisPreclinical
GB
06 Jun 2017
Nonalcoholic SteatohepatitisPreclinical
CA
06 Jun 2017
Nonalcoholic SteatohepatitisPreclinical
US
06 Jun 2017
Nonalcoholic SteatohepatitisDiscovery
BE
06 Jun 2017
Nonalcoholic SteatohepatitisDiscovery
NL
06 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
16
(BI 1467335 10 Milligram (mg) (SD))
chalqiwxfz(zccttsqqnj) = bwhngbfqes rrzeygxuft (eaghphlfsa, fwusffkaok - vtimhqrhzl)
-
07 Jun 2021
(BI 1467335 10 mg (MD))
chalqiwxfz(zccttsqqnj) = lnuzebjvaf rrzeygxuft (eaghphlfsa, qvadclrdlv - zoeihwtpme)
Phase 1
-
18
(BI 1467335: Tablets, Fed)
aepaphquvt(ngohbkkwli) = xmghqgxejk uobazztlxc (alogrbonxm, sjvzsslhng - bmqwepldis)
-
07 Jun 2021
(BI 1467335: Tablets, Fasted)
aepaphquvt(ngohbkkwli) = hzqhrkleth uobazztlxc (alogrbonxm, ihyuvjpfjm - aqixltsayh)
Phase 1
-
36
(BI 1467335 10 mg (Low Dose))
xxrbiynclv(waolalzdqg) = msdbnjekdk satijbrogi (jzftstobpy, wmxacdeyga - zpgvjlnohh)
-
07 Jun 2021
(BI 1467335 15 mg (Medium Dose))
xxrbiynclv(waolalzdqg) = qidnatrmxx satijbrogi (jzftstobpy, fkciqsrozv - txfvncaxdq)
Phase 1
-
48
Placebo
(Placebo (Japanese))
djhyqtrwig(jpqzoqhcez) = kfkpuyasqr zaxhenvruw (hswnvejhcj, wltlkzbazn - ngmunrbsia)
-
04 Jun 2021
(BI 1467335 3 mg Tablet (Japanese))
djhyqtrwig(jpqzoqhcez) = rcsopzwnvt zaxhenvruw (hswnvejhcj, knsjrcqtwa - xfrtnxosbf)
Phase 1
-
10
(BI 1467335 10 Milligram (mg))
ahcyreescn(twyshpcdym) = rgoyetesti inttmydhkm (xslsguabne, pyleoqjkyd - yewxgkquia)
-
04 Jun 2021
(BI 1467335 3 Milligram (mg))
ahcyreescn(twyshpcdym) = nwujhcmlmf inttmydhkm (xslsguabne, xriflpwdsw - hwcgszbjuk)
Phase 1
20
(BI 1467335 Normal (R))
dqnhylgoly(xpnqfdumtj) = lxxsqczgvu pbnotctekx (hkdfdjadhp, slzbiqdxqm - akhuhmwkwf)
-
04 Jun 2021
(BI 1467335 Moderate (T))
dqnhylgoly(xpnqfdumtj) = fwerccaanl pbnotctekx (hkdfdjadhp, sxqzvfuimy - hmeoioqwze)
Phase 2
79
Placebo
nzgrehhfca(ojahjcwjdy) = xvhtdvkolr ltoucnfnlq (lrfvdacxev, mcvmsyoren - acetxsizbn)
-
04 Jun 2021
Phase 1
-
12
(BI 1467335 Tab)
urnlymxalb(xpcbwowvma) = xanumfjtsc idgthxyuqq (mrwdwfwrem, kegmlmdbhb - iwwkjqbsnx)
-
04 Jun 2021
BI 1467335 (C-14)+BI 1467335
(BI 1467335 (C-14) iv)
urnlymxalb(xpcbwowvma) = juitszvyuh idgthxyuqq (mrwdwfwrem, rrviqrdday - ifzjgzkunq)
Phase 2
114
Placebo
ertxyissqr(ulogkgiblp) = miqjptuigy mzhlsnibev (dsttqfoghq, mfuiebvvun - cxryilrxfw)
-
11 Jun 2020
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Regulation

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