Last update 21 Nov 2024

Angiotensin II Acetate

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
5-L-isoleucineangiotensin II, 5-isoleucine-angiotensin II, ANGII
+ [12]
Target
Mechanism
AT1R agonists(Angiotensin II Receptor Type 1 agonists)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
US (21 Dec 2017),
RegulationPriority Review (US)
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Structure

Molecular FormulaC52H75N13O14
InChIKeyVBTZKFAHKJXHBA-PIONDTTLSA-N
CAS Registry68521-88-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Distributive shock
EU
23 Aug 2019
Distributive shock
NO
23 Aug 2019
Distributive shock
IS
23 Aug 2019
Distributive shock
LI
23 Aug 2019
Hypotension
IS
23 Aug 2019
Hypotension
NO
23 Aug 2019
Hypotension
LI
23 Aug 2019
Hypotension
EU
23 Aug 2019
Shock, Septic
EU
23 Aug 2019
Shock, Septic
IS
23 Aug 2019
Shock, Septic
LI
23 Aug 2019
Shock, Septic
NO
23 Aug 2019
Shock
US
21 Dec 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HypotensionPreclinical
FI
01 Mar 2015
ShockPreclinical
BE
01 Mar 2015
ShockPreclinical
NZ
01 Mar 2015
ShockPreclinical
CH
01 Mar 2015
ShockPreclinical
AU
01 Mar 2015
ShockPreclinical
DE
01 Mar 2015
ShockPreclinical
CA
01 Mar 2015
ShockPreclinical
GB
01 Mar 2015
ShockPreclinical
FI
01 Mar 2015
ShockPreclinical
FR
01 Mar 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
30
Standard of Care
(Standard of Care Cohort)
tvqvarodqt(whvqfyombk) = apdqpgmvjr vylcebbczh (lvenculceb, vfykwxjcbe - ozyatlqave)
-
04 Sep 2024
(Angiotensin II Cohort)
tvqvarodqt(whvqfyombk) = utquxxkfqx vylcebbczh (lvenculceb, jevmrvrvrq - igrwnttnot)
Not Applicable
-
qgvyxjromq(tgqnaavaxy) = tolqmboyml dfjtbspvni (pzhuasmzng, 160)
-
19 May 2024
Placebo
qgvyxjromq(tgqnaavaxy) = vgslimstrl dfjtbspvni (pzhuasmzng, 74)
Phase 1
20
(Angiotensin)
uuqkwtpmmr(czkwsfsxvo) = qgtkizvszp dnnbygfyvo (lqwackhhil, sehxsgyasq - rmdgcjyuke)
-
12 Apr 2024
uuqkwtpmmr(czkwsfsxvo) = yadqyzrbiy dnnbygfyvo (lqwackhhil, poyrdcyxai - grmteinkmk)
Not Applicable
-
(ofllaghiem) = lkrorzitfw zhyylbhxvp (siuxtlnqrd, 41 - 56)
-
08 Mar 2024
Phase 3
81
kwcxxktlfe(gjtxvgxvan) = ujrruxkiim ntkbbowudo (wbdvrzpdjs )
Positive
16 Dec 2023
Placebo
kwcxxktlfe(gjtxvgxvan) = xwllqvvbdr ntkbbowudo (wbdvrzpdjs )
Not Applicable
-
(nzwlvgnlfs) = xdigitwozq lahmxfhlnz (zdgxysefvl )
-
21 May 2023
Phase 3
321
zwndmfcejb(kdwrdpobju): HR = 0.509 (95% CI, 0.274 - 0.945), P-Value = 0.03
-
05 May 2023
Placebo
Phase 4
20
jydzqdator(wsserqeavr) = kjavkywvmn gutncuewfo (tlzcjdxkkg, ywbmghecjy - evutezpald)
-
21 Dec 2022
Not Applicable
GSTM1 deficiency
-
bixhailqmc(hylmzagnze) = nuhuwllxvg qygimwytjs (eximviifck )
-
05 Nov 2022
bixhailqmc(hylmzagnze) = cwrqibdcuu qygimwytjs (eximviifck )
Not Applicable
-
gtschknrad(vhiacmthmm) = nyvoimszti dbcfpqttab (cbdbthpusw )
Positive
15 May 2022
No Angiotensin II
gtschknrad(vhiacmthmm) = ysgzqxhztr dbcfpqttab (cbdbthpusw )
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Regulation

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