Last update 01 Nov 2024

Aripiprazole/Escitalopram

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Escitalopram/aripiprazole, OPC-14597/escitalopram
Target
5-HT1A receptor x 5-HT2A receptor x D2 receptor x D3 receptor x SERT
Mechanism
5-HT1A receptor agonists(Serotonin 1a (5-HT1a) receptor agonists), 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor agonists(Dopamine D2 receptor agonists)
+ [2]
Therapeutic Areas
Other Diseases
Active Indication-
Inactive Indication
Depressive Disorder, Major
Originator Organization
Otsuka Pharmaceutical Co., Ltd.Otsuka Pharmaceutical Co., Ltd.
Active Organization-
Inactive Organization
Otsuka Pharmaceutical Development & Commercialization, Inc.
Drug Highest PhasePendingPhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC20H21FN2O
InChIKeyWSEQXVZVJXJVFP-FQEVSTJZSA-N
CAS Registry128196-01-0
View All Structures (2)

Related

1
Clinical Trials associated with Aripiprazole/Escitalopram
NCT06433635 / Not yet recruitingPhase 4IIT
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
100 Clinical Results associated with Aripiprazole/Escitalopram
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100 Translational Medicine associated with Aripiprazole/Escitalopram
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100 Patents (Medical) associated with Aripiprazole/Escitalopram
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100 Deals associated with Aripiprazole/Escitalopram
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Depressive Disorder, MajorPhase 3
SK
Otsuka Pharmaceutical Development & Commercialization, Inc.
03 Nov 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
FDA_CDER
ManualManual
Not Applicable
Schizophrenia
-
(Study 1)
(atbestsdbz) = zlfntvtcva ofsyoydvoz (ifrwsiwrgn, 2.40)
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Positive
22 Jul 2024
Aripiprazole (30 mg/day)
(Study 1)
(atbestsdbz) = iwetqrjrvs ofsyoydvoz (ifrwsiwrgn, 2.39)
Pubmed | J Am Acad Child Adolesc Psychiatry
Not Applicable
Irritable Mood
-
(edzbzobfee) = There were two serious adverse events: presyncope (5 mg/day) and aggression (10 mg/day) yxigkykryu (wikdzcuznx )
Positive
01 Nov 2009
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Clinical Trial

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Approval

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Regulation

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