Last update 20 Mar 2025

SY-5609

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
Action
inhibitors
Mechanism
CDK7 inhibitors(Cyclin-dependent kinase 7 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC23H26F3N6OP
InChIKeyJDJOUBVVSQDIRC-AWEZNQCLSA-N
CAS Registry2417302-07-7

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Colorectal CarcinomaPhase 1
Australia
22 Oct 2021
Metastatic Colorectal CarcinomaPhase 1
United States
22 Oct 2021
Metastatic Colorectal CarcinomaPhase 1
Taiwan Province
22 Oct 2021
Metastatic Colorectal CarcinomaPhase 1
Germany
22 Oct 2021
Advanced Malignant Solid NeoplasmPhase 1
United States
23 Jan 2020
Hormone receptor positive breast cancerPhase 1
United States
23 Jan 2020
Human epidermal growth factor 2 negative carcinoma of breastPhase 1
United States
23 Jan 2020
Pancreatic Ductal AdenocarcinomaPhase 1
United States
23 Jan 2020
PIK3CA mutation/HR-positive/HER2-negative Breast CancerPhase 1
United States
23 Jan 2020
Small Cell Lung CancerPhase 1
United States
23 Jan 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
14
(kleuwaaedw) = giysjowbjr qhwdnitizt (gqpubqgtyz )
Positive
31 May 2023
Phase 1
87
(SLIs)
-
Positive
26 May 2023
gemcitabine+SY-5609
(SLIs)
(mimyqytvux) = vgfcknsvdv bpvpxulmwf (jgzrmubzmn )
Phase 1
-
(caqeyohdtr) = jsrhhvpear yeealmpwse (gardnzxotp )
-
02 Jun 2022
Phase 1
51
(prpkvnvldi) = (≥20%) included nausea, diarrhea, fatigue, decreased appetite, and thrombocytopenia; majority were low grade (1/2) and reversible elldbpoisa (opmprdvfww )
Positive
20 Sep 2021
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Core Patent

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Approval

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Regulation

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