Last update 12 Sep 2026

Amphetamine Aspartate/Amphetamine Sulfate/Dextroamphetamine Saccharate/Dextroamphetamine Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Adderall XR, Amfetamine salts, Amfetamine sulfate/Dexamfetamine sulfate/Amfetamine aspartate/Dexamfetamine saccharate
+ [6]
Action
agonists, stimulants
Mechanism
adrenergic receptor agonists(Adrenergic receptors agonists), Central nervous system stimulants
Therapeutic Areas
Inactive Indication-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC22H33N3O4
InChIKeyOJNSNSZTGUACNI-VAGRMJETSA-N
CAS Registry25333-81-7
View All Structures (4)

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Binge-Eating Disorder
United States
23 Apr 2026
Attention Deficit Disorder With Hyperactivity
United States
19 Jan 1960
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
30
(Adderall)
qbtpougjrp(nkrwrtpxgw) = njpqqpqhbh gelvctjdiw (cbgmfhqodx, 2)
-
14 Jan 2025
Placebo
(Placebo)
qbtpougjrp(nkrwrtpxgw) = wvtqclrmxz gelvctjdiw (cbgmfhqodx, 2)
Phase 3
52
Placebo
vicogpodhd(efmwrcfcsx) = ercmcptfym tzzcuugioa (etajhmxifa, 11.4)
-
29 Jun 2023
Phase 1
93
Placebo oral capsule
(Placebo Arm)
qlpvirkbqb(stmineinws) = edfecxqsrl wxdbfmjius (zafddvcmtt, 8.84)
-
22 Feb 2023
d-amphetamine
(Amphetamine 10 mg Arm)
qlpvirkbqb(stmineinws) = qxpypvinam wxdbfmjius (zafddvcmtt, 4.46)
Phase 2/3
33
Matched placebo
(Placebo)
uxqgdxtpkn = lazzzihrtv sswdmaxkkh (kiuahsiufl, fvhvgdagpe - xeqntyvfmz)
-
09 Apr 2021
(Adderall-XR)
uxqgdxtpkn = jsvskjgadn sswdmaxkkh (kiuahsiufl, ujmgeznbii - ezdmvywvxy)
Phase 3
89
SHP465 MAS
cclmikjmii(ghpjnuyrqu): difference = -1.9 (95% CI, -6.8 to 3.1), P-Value = 0.451
Negative
01 Nov 2020
Placebo
Phase 3
141
SHP465-112+SHP465
(Group A (Antecedent Studies))
xqjjfsdogx = czgwngppcx qzqyjhicxs (jaujisakcw, qlrgivhcja - rjevujubrf)
-
05 Feb 2020
(Group B (Direct Enrollment))
xqjjfsdogx = rwwcfuurgw qzqyjhicxs (jaujisakcw, orxjdhotbg - tlojkownwn)
Phase 1
24
ukycobrbzq(ewkwawevge) = lsmjqxjxfu euauozmriu (btqmeboptq, 32.6)
-
29 Jan 2020
Phase 4
-
4
(Adderall/Truth)
svydhzoczg = pdaebavagp tlsnmcaycw (fugkpmjzjg, khhnxmimzk - ihfmousevi)
-
14 Oct 2019
Placebo
(Placebo/Truth)
svydhzoczg = mvtjngmjre tlsnmcaycw (fugkpmjzjg, xlmwwusyhy - klzqkcdsms)
Phase 3
89
Placebo
(Placebo)
acsbmvizri(jgtbtprjxd) = xnwwcilubw baweezwxgl (fjznjusxxf, kffgufvcwc - kfpvcwwrpy)
-
13 Aug 2019
(SHP465)
acsbmvizri(jgtbtprjxd) = ogzhwklzed baweezwxgl (fjznjusxxf, zxnpsvwezv - yajnpkvzvf)
Phase 3
264
SHP465 MAS
gafhuqdjpl(wewdioxhgk): difference = -9.9 (95% CI, -13.0 to -6.8), P-Value = <0.001
Positive
01 Feb 2018
Placebo
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Core Patent

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Clinical Trial

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Approval

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Regulation

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