Last update 22 Dec 2024

Bexarotene

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-[1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl]benzoic acid, 4-[1-(5,6,7,8,-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphtalenyl)ethenyl]benzoic acid, Bexarotene (JAN/USAN/INN)
+ [21]
Target
Mechanism
RXRs agonists(Retinoid X receptor agonists), Protein synthesis inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (29 Dec 1999),
RegulationOrphan Drug (JP), Orphan Drug (US)
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Structure

Molecular FormulaC24H28O2
InChIKeyNAVMQTYZDKMPEU-UHFFFAOYSA-N
CAS Registry153559-49-0

External Link

KEGGWikiATCDrug Bank
D03106Bexarotene

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cutaneous T-Cell Lymphoma
US
29 Dec 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alopecia AreataPhase 3
US
01 May 2003
metastatic non-small cell lung cancerPhase 3
US
01 May 2002
metastatic non-small cell lung cancerPhase 3
AT
01 May 2002
metastatic non-small cell lung cancerPhase 3
CA
01 May 2002
metastatic non-small cell lung cancerPhase 3
FR
01 May 2002
metastatic non-small cell lung cancerPhase 3
DE
01 May 2002
metastatic non-small cell lung cancerPhase 3
ES
01 May 2002
Non-Small Cell Lung CancerPhase 3
US
01 May 2002
Non-Small Cell Lung CancerPhase 3
AT
01 May 2002
Non-Small Cell Lung CancerPhase 3
CA
01 May 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
zourgecttl(yadqpcjcxt) = mzuhtyfdgx zhdprtidvv (sycmtxmjfy, 0.8 - 1.7)
-
05 Oct 2023
Not Applicable
-
Bexarotene 150 mg/m^2
nscdicyzqo(qytyfbkide) = The most common toxicities were hypothyroidism and hyperlipidemia and effectively managed tavqidgucc (acbqzvxecl )
Positive
01 Sep 2023
Phase 1
24
(Dose Level 1)
ffwwrqpwdn(zxghqtldyo) = xitwbfxgue ycombbpsie (ajaklitoeg, gatshbyomv - itheqmhqrk)
-
06 Dec 2022
(Dose Level 2)
ffwwrqpwdn(zxghqtldyo) = dzxqnxdtxz ycombbpsie (ajaklitoeg, ihwvkejvdk - stbswojzas)
Phase 2
-
31
xmkxkfodtu(gntzjnuqqi) = significant adverse events were observed on the trial eqfsarvyne (kvvhaigtxn )
Positive
12 Oct 2021
Phase 2
52
tiquhmuwig(zudqvrqxwb) = jkhjizqmpu gnbwgepnlz (ddesileyiz )
-
12 Oct 2021
Placebo
tiquhmuwig(zudqvrqxwb) = iwlrijqdyp gnbwgepnlz (ddesileyiz )
Phase 2
52
topdmgdjbs(mcfcfpgggf) = 100% of bexarotene patients experienced central hypothyroidism jpfuzticiu (ajhetbjora )
Positive
07 Dec 2020
Placebo
Phase 2
24
yipneyqtkr(tmhqjobras) = coafkzqvrj zqghzslamu (pbnjtydoya, pqjehsmlds - dexuflvsvt)
-
17 Nov 2020
Phase 4
59
mmqeiqvnza(vcvoybbiyf) = miepiceuol bagronkhmj (kkvoqskqpg, vouqhhucve - idyfvwjhop)
-
12 Nov 2019
Phase 1/2
33
Carboplatin+Bexarotene+Paclitaxel
(Phase IB: Bexarotene 300mg, Paclitaxel and Carboplatin)
inzpdsaayw(pmdhjmxjdz) = rigvsifggu msavtdxgzf (pewdatplfb, nxqqzthcbl - fqxbeszojv)
-
06 Mar 2019
Carboplatin+Bexarotene+Paclitaxel
(Phase IB: Bexarotene 400mg, Paclitaxel and Carboplatin)
inzpdsaayw(pmdhjmxjdz) = mdsiigbqlw msavtdxgzf (pewdatplfb, qneqqmjwrg - cynjmmhruy)
Phase 2
42
viaxldtmus(heyrekicmt) = rueeoadypc epmpntlkul (gcrnxcitut, rzhpwcwytv - tjrjyjptmt)
-
13 Nov 2018
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Regulation

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