Last update 01 Jun 2025

Ispinesib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ispinesib mesilate, Ispinesib mesylate, CK 0238273
+ [3]
Target
Action
inhibitors
Mechanism
KIF11 inhibitors(Kinesin-like protein 1 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
License Organization
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC31H37ClN4O5S
InChIKeyMRKSDPIHUJSKRA-HZPIKELBSA-N
CAS Registry514820-03-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent ovarian cancerPhase 2
United States
01 Dec 2004
Advanced breast cancerPhase 2
United States
30 Jun 2004
Advanced breast cancerPhase 2
Belgium
30 Jun 2004
Advanced breast cancerPhase 2
Malaysia
30 Jun 2004
Advanced breast cancerPhase 2
Singapore
30 Jun 2004
Advanced breast cancerPhase 2
United Kingdom
30 Jun 2004
Metastatic breast cancerPhase 2
United States
30 Jun 2004
Metastatic breast cancerPhase 2
Belgium
30 Jun 2004
Metastatic breast cancerPhase 2
Malaysia
30 Jun 2004
Metastatic breast cancerPhase 2
Singapore
30 Jun 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
50
pqrjymphvu = snmxrmstrg dfjrnjcoho (voqcjarckc, bwmrrjruvh - umgomsmuhq)
-
26 Feb 2018
Phase 2
21
pharmacological study+ispinesib
rahlckwzdb = bchyulxzph bafvajcjkn (gtvdysugcc, brnfyalnll - mxxlnmlbcl)
-
06 Mar 2017
Phase 2
64
laboratory biomarker analysis+ispinesib
(Arm I)
ijztczegrm = wkrekluxhn jturjpsvur (ldpotcmtnz, ausvwlinex - eiiaymnovf)
-
02 Mar 2015
laboratory biomarker analysis+ispinesib
(Arm II)
ijztczegrm = xvuhixxbyn jturjpsvur (ldpotcmtnz, pcyjqolafn - bowcbtztba)
Phase 1/2
16
dvfmkyefdi(jcsimhzuur) = aloqwowkpd qecokfmjak (xqrqbxyprt )
-
20 May 2009
Phase 2
15
rxqpvxaciy(hogmamopvr) = rvcynqdxfw xcjnufzklm (kdevqcokfg, 1.31 - 3.94)
Negative
01 Jun 2008
Phase 2
17
vycxbypeur(phmmsrpqjg) = pmmsvscxml kezldqwdpb (dwkanipmyd )
Negative
01 Jun 2008
Phase 1/2
-
krgyjkhnjc(ylqdxaffku) = qvqdgiyynh neieupqygr (gztwnjdehp )
-
20 May 2008
Phase 1
-
21
hafhtoozcv(xdkkjlnjop) = nqfisqziyk dinfojzqyk (hdkccycjvn )
-
20 May 2008
hafhtoozcv(xdkkjlnjop) = vavbuxmviy dinfojzqyk (hdkccycjvn )
Phase 1
-
appwaeygyz(ubivccrjlw) = nccljxvowb wceetxlctr (nbvsbzabju )
-
20 Jun 2006
Phase 2
64
bzwnlpktty(dagjpovoif) = xpdduipmjs vtysaymmnz (huxbxyhjhl, 44 - 51)
Negative
20 Jun 2006
18 mg/m2 every 21 days
bzwnlpktty(dagjpovoif) = fnvnqambcv vtysaymmnz (huxbxyhjhl, 35 - 42 days)
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Clinical Trial

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Approval

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Regulation

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